Property Summary

NCBI Gene PubMed Count 17
PubMed Score 17.64
PubTator Score 12.29

Knowledge Summary


No data available


  Disease (2)


  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.115 4.7e-04
intraductal papillary-mucinous neoplasm ... 1.200 3.7e-03
colon cancer 1.200 1.4e-02
subependymal giant cell astrocytoma 1.040 4.4e-02


Accession Q9NQ31 Q8NBS2 Q8TAC6 Q8TAD3 Q8TAE0
Symbols BCA3


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (11)

25526186 The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression.
24886575 HIV-1 PR(D25N) directly interacts with BCA3 in cells and co-localizes with BCA3 in the cytoplasm, particularly at the mitochondria
24659101 Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity.
24413079 Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis.
23319652 Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20562110 action of PKA signaling on the NF-kappaB activation cascade
19913121 Observational study of gene-disease association. (HuGE Navigator)
18178962 AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus.
15630084 AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits.
12527432 characterization of the BCA3 gene; BCA3 is expressed in breast tumor cells in vivo, and not in surrounding stromal tissue

AA Sequence


Text Mined References (17)

PMID Year Title
25526186 2014 Cloning and functional identification of a novel BCA3 splice.
24659101 2014 Breast cancer-associated protein--a novel binding partner of Mason-Pfizer monkey virus protease.
24413079 2015 Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma.
23319652 2013 A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20562110 2010 A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18178962 2008 AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15630084 2005 A-kinase-interacting protein localizes protein kinase A in the nucleus.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12527432 2003 Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11528127 2001 Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.