AKAP3
A-kinase anchor protein 3
Protein Summary
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
- ENST00000228850
- ENSP00000228850
- ENSG00000111254
- ENST00000545990
- ENSP00000440994
- AKAP110
- SOB1
- CT82
- SOB1
- FSP95
- PRKA3
- HEL159
- AKAP110
- AKAP 110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.91 | ||
tissue sample | 0.69 | ||
cell type or tissue | 0.63 | ||
virus perturbation | 0.59 | ||
cell line | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.88 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 168 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.88 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 168 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0