Tbio | A-kinase anchor protein 10, mitochondrial |
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Cardiac Conduction Defect | 1 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Bipolar Disorder | 666 |
Conduction disorder of the heart | 79 |
Disease | Target Count | P-value |
---|---|---|
glioblastoma multiforme | 142 | 1.3e-19 |
ovarian cancer | 8520 | 6.7e-14 |
Pick disease | 1894 | 8.6e-05 |
intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.2e-04 |
medulloblastoma, large-cell | 6241 | 9.9e-04 |
oligodendroglioma | 2850 | 1.0e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.0e-03 |
ependymoma | 4679 | 4.3e-03 |
astrocytic glioma | 2597 | 5.3e-03 |
osteosarcoma | 7950 | 6.7e-03 |
lung cancer | 4740 | 1.0e-02 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.3e-02 |
ulcerative colitis | 1819 | 3.6e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Smith-Magenis syndrome | 29 | 3.423 | 1.7 |
Wolf-Hirschhorn syndrome | 32 | 3.152 | 1.6 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | 2.000 | 5.3e-03 |
ependymoma | 1.200 | 4.3e-03 |
glioblastoma multiforme | 1.100 | 1.3e-19 |
intraductal papillary-mucinous adenoma (... | 2.500 | 3.2e-04 |
intraductal papillary-mucinous carcinoma... | 1.500 | 2.0e-03 |
intraductal papillary-mucinous neoplasm ... | 1.400 | 3.3e-02 |
lung cancer | 1.100 | 1.0e-02 |
medulloblastoma, large-cell | -1.500 | 9.9e-04 |
oligodendroglioma | 1.200 | 1.0e-03 |
osteosarcoma | -1.147 | 6.7e-03 |
ovarian cancer | -1.200 | 6.7e-14 |
Pick disease | 1.300 | 8.6e-05 |
ulcerative colitis | -1.455 | 3.6e-02 |
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSH 1 - 70 VAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFI 71 - 140 QFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTDSLDKRLEDS 141 - 210 GSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPA 211 - 280 SPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSA 281 - 350 MEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA 351 - 420 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKV 421 - 490 FLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGSSDSSASQSSVKKASIKILKN 491 - 560 FDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVRKSKGSMFSQAMKKWVQGNTDEA 561 - 630 QEELAWKIAKMIVSDIMQQAQYDQPLEKSTKL 631 - 662 //