Tbio AK2 Adenylate kinase 2, mitochondrial

Protein Summary

Description

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P54819
• A8K6L1
• B4DHH7
• B4DL64
• Q16856
• Q5EB54
• Q5TIF7
• Q8TCY2
• Q8TCY3
• AK 2

Gene Name

• AK2

Ensembl ID

• ENST00000354858
• ENSP00000346921
• ENSG00000004455
• ENST00000373449
• ENSP00000362548

Symbol

• ADK2
• ADK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
virus perturbation	1
disease perturbation	0.97
transcription factor perturbation	0.94
microRNA	0.91

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Adenylate Kinase 2, Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleotide Kinase / Adenylate Kinase Family / Ak2 Subfamily / Adenylate Kinase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.86   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 426   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.86   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0