Tbio AGPAT4 1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Protein Summary

Description

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NRZ5
• B4DSF9
• Q5TEF0

Gene Name

• AGPAT4

Ensembl ID

• ENST00000320285
• ENSP00000314036
• ENSG00000026652

Symbol

• 1-AGPAT4
• dJ473J16.2
• LPAAT-delta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
trait	0.75
kinase perturbation	0.71
transcription factor binding site profile	0.71
transcription factor	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.76   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.76   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0