AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Protein Summary
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
- ENST00000397238
- ENSP00000380413
- ENSG00000133612
- ENST00000463381
- ENSP00000418016
- ENST00000473312
- ENSP00000418921
- ENST00000622464
- ENSP00000480655
- CENTG3
- CRAG
- AGAP-3
- CENTG3
- MRIP-1
- cnt-g3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
protein domain | 0.97 | ||
transcription factor binding site profile | 0.82 | ||
transcription factor | 0.69 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.95 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.95 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0