AFMID
Kynurenine formamidase
Protein Summary
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
- ENST00000327898
- ENSP00000328938
- ENSG00000183077
- ENST00000409257
- ENSP00000386890
- KF
- FKF
- KFA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.86 | ||
histone modification site profile | 0.77 | ||
tissue sample | 0.73 | ||
biological process | 0.66 | ||
cell type or tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.18 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.18 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0