Tclin Adenosine receptor A2b

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Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

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Property Summary

Ligand Count	904
NCBI Gene PubMed Count	110
PubMed Score	105.39

PubTator Score	52.58

Knowledge Summary

Patent (3,689)

TINX Plot

Disease (4)

Disease	Target Count	Z-score	Confidence
Neoplasm Metastasis	168	0.0	0.0
Reperfusion Injury	86	0.0	0.0
Sepsis	24	0.0	0.0

Disease	Target Count
Acute exacerbation of asthma	14
Allergic rhinitis	94
Apnea in the newborn	3
Asthma	385
Asthma management	19
Asthma night-time symptoms	7
Asthma-chronic obstructive pulmonary disease overlap syndrome	7
Backache	8
Bronchitis	43
Bronchospasm	9
COPD Associated with Chronic Bronchitis	11
Chronic Obstructive Pulmonary Disease with Bronchospasms	8
Cluster Headache Prevention	6
Cluster headache syndrome	8
Common cold	67
Disorder of lung	7
Dysmenorrhea	21
Headache disorder	19
Influenza-like symptoms	16
Joint pain	8
Migraine	83
Myocardial Perfusion Imaging Adjunct	25
Nasal congestion	21
Nasal discharge	24
Pain	103
Paroxysmal supraventricular tachycardia	12
Peripheral vascular disease	87
Pulmonary emphysema	48
Sinus headache	16
Spasticity	26
Tension-type headache	10
Vascular headache	7

Disease	Target Count	P-value
non-small cell lung cancer	2890	8.5e-08
pancreatic cancer	2398	1.7e-05
tuberculosis	2010	3.0e-04
medulloblastoma, large-cell	6241	1.4e-03
astrocytic glioma	2597	7.4e-03
group 3 medulloblastoma	4104	9.0e-03

Disease	Target Count	Z-score	Confidence
Vascular disease	319	3.173	1.6

Differential Expression (6)

Disease	log2 FC	p
astrocytic glioma	-1.400	7.4e-03
group 3 medulloblastoma	-1.900	9.0e-03
medulloblastoma, large-cell	-1.700	1.4e-03
non-small cell lung cancer	1.208	8.5e-08
pancreatic cancer	1.300	1.7e-05
tuberculosis	-1.800	3.0e-04

Colon - Transverse 17,825

Skin - Not Sun Exposed (Suprapubic) 18,081

Skin - Sun Exposed (Lower leg) 17,968

Esophagus - Mucosa 18,076

Cells - Transformed fibroblasts 17,577

Brain - Anterior cingulate cortex (BA24) 17,989

Vagina 17,834

Brain - Cortex 18,039

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Frontal Cortex (BA9) 18,069

Brain - Caudate (basal ganglia) 18,001

Brain - Amygdala 18,006

Brain - Cerebellum 17,983

Brain - Putamen (basal ganglia) 17,863

Brain - Hippocampus 18,011

Colon - Sigmoid 18,089

Pituitary 18,147

Brain - Cerebellar Hemisphere 18,015

Testis 18,518

Brain - Hypothalamus 18,169

Lung 18,057

Prostate 18,213

Small Intestine - Terminal Ileum 17,954

Brain - Substantia nigra 17,981

Nerve - Tibial 18,007

Spleen 17,614

Uterus 17,618

Adrenal Gland 18,071

Esophagus - Gastroesophageal Junction 18,000

Ovary 17,971

Minor Salivary Gland 18,005

Adipose - Subcutaneous 18,110

Brain - Spinal cord (cervical c-1) 17,973

Heart - Left Ventricle 18,006

Adipose - Visceral (Omentum) 17,937

Stomach 17,879

Artery - Coronary 17,949

Breast - Mammary Tissue 18,103

Esophagus - Muscularis 18,017

Heart - Atrial Appendage 17,896

Thyroid 18,024

Pancreas 18,123

Whole Blood 17,439

Artery - Tibial 17,631

Cells - EBV-transformed lymphocytes 18,186

Kidney - Cortex 17,329

Artery - Aorta 17,896

Muscle - Skeletal 17,778

Liver 18,071

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

placenta 15,937

prostate 16,460

rectum 15,705

seminal vesicle 15,918

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

See source...

brl1 9

See source...

Synonym

Accession	P29275
Symbols	ADORA2

Gene

ADORA2B

PANTHER Protein Class (2)

receptor 400

G-protein coupled receptor 221

Ortholog (9)

Species	Source	Disease
Cow 15,316	Inparanoid OMA EggNOG
Opossum 12,223	Inparanoid OMA EggNOG
Chicken 7,823	Inparanoid OMA
Zebrafish 9,725	Inparanoid OMA
Chimp 14,136	OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG

UniProt Keyword (13)

Complete proteome 20,231

Reference proteome 20,231

Cell membrane 3,390

Disulfide bond 3,599

G-protein coupled receptor 830

Glycoprotein 4,623

Membrane 7,361

Receptor 1,502

Transducer 887

Transmembrane 5,228

See all...

GO Function (1)

G-protein coupled adenosine receptor act... 5

GO Component (3)

plasma membrane 4,414

integral component of plasma membrane 1,418

intracellular 566

GO Process (16)

G-protein coupled receptor signaling pat... 1,053

activation of MAPK activity 107

cellular protein metabolic process 192

adenylate cyclase-activating G-protein c... 43

JNK cascade 50

positive regulation of vascular endothel... 27

cellular defense response 58

activation of adenylate cyclase activity 38

positive regulation of interleukin-6 pro... 44

excretion 37

See all...

Compartment GO Term (12)

Cell 16,178

Cell part 16,177

Cell periphery 5,382

Integral component of membrane 5,331

Integral component of plasma membrane 1,693

Intrinsic component of membrane 5,458

Intrinsic component of plasma membrane 1,749

Membrane 8,531

Membrane part 6,554

Plasma membrane 5,830

Plasma membrane part 2,594

cellular_component 18,320

IMPC Phenotype (3)

preweaning lethality, incomplete penetra... 499

increased fasted circulating glucose lev... 76

convulsive seizures 13

MGI Phenotype (10)

homeostasis-metabolism phenotype 4,747

cellular phenotype 3,637

nervous system phenotype 3,447

hematopoietic system phenotype 3,383

cardiovascular system phenotype 2,660

reproductive system phenotype 1,999

mortality-aging 5,018

embryo phenotype 1,827

immune system phenotype 3,461

behavior-neurological phenotype 3,401

GWAS Trait (1)

Immune reponse to smallpox (secreted IL-... 7

HCA RNA Cell Line (55)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (32)

Neuroactive ligand-receptor interaction 276

Alcoholism 147

Rap1 signaling pathway 209

Vascular smooth muscle contraction 123

Calcium signaling pathway 183

http://pathwaycommons.org/pc2/Pathway_27... 235

http://pathwaycommons.org/pc2/Pathway_b5... 233

http://pathwaycommons.org/pc2/Pathway_db... 223

http://pathwaycommons.org/pc2/Pathway_ea... 224

http://pathwaycommons.org/pc2/Pathway_f3... 224

See all...

Drug (8)

caffeine
pKi 4.77

adenosine
pEC50 4.62

theophylline
pKi 5.57

pentoxifylline
pKi 5.29

choline theophyllinate
pKi 5.57

bufylline
pKi 5.57

regadenoson
pKi 5.00

istradefylline
pKi 5.00

Ligand (892)

CHEMBL163968
pKi 7.00

CHEMBL217076
pKi 7.00

CHEMBL32150
pKi 7.00

CHEMBL210319
pKi 7.00

CHEMBL199692
pKi 7.00

CHEMBL199280
pKi 7.00

CHEMBL409440
pKi 7.00

CHEMBL1169969
pKi 7.00

CHEMBL212217
pKi 7.00

CHEMBL164281
pKi 7.00

CHEMBL1170168
pKi 7.01

CHEMBL352345
pKi 7.01

CHEMBL445056
pKi 7.02

CHEMBL432273
pKi 7.02

CHEMBL2112067
pKi 7.03

CHEMBL550638
pKi 7.03

CHEMBL604492
pKi 7.03

CHEMBL180236
pKi 7.04

CHEMBL201447
pKi 7.04

CHEMBL414157
pKi 7.05

See all 892 ligands...

Gene RIF (94)

AA Sequence

MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG      1 - 70
FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTP     71 - 140
FLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVAC    141 - 210
RQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSH    211 - 280
ANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL                      281 - 332
//

Text Mined References (110)

Summary
Details

	PMID	Year	Title

Tclin Adenosine receptor A2b Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent (3,689)

TINX Plot

Disease (4)

Expression

Differential Expression (6)

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (9)

UniProt Keyword (13)

GO Function (1)

GO Component (3)

GO Process (16)

Compartment GO Term (12)

IMPC Phenotype (3)

MGI Phenotype (10)

GWAS Trait (1)

HCA RNA Cell Line (55)

Pathway (32)

Drug (8)

Ligand (892)

Gene RIF (94)

AA Sequence

Text Mined References (110)

Tclin Adenosine receptor A2b

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