Tclin | Adenosine receptor A2b |
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 904 |
NCBI Gene PubMed Count | 110 |
PubMed Score | 105.39 |
PubTator Score | 52.58 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 8.5e-08 |
pancreatic cancer | 2398 | 1.7e-05 |
tuberculosis | 2010 | 3.0e-04 |
medulloblastoma, large-cell | 6241 | 1.4e-03 |
astrocytic glioma | 2597 | 7.4e-03 |
group 3 medulloblastoma | 4104 | 9.0e-03 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Vascular disease | 319 | 3.173 | 1.6 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -1.400 | 7.4e-03 |
group 3 medulloblastoma | -1.900 | 9.0e-03 |
medulloblastoma, large-cell | -1.700 | 1.4e-03 |
non-small cell lung cancer | 1.208 | 8.5e-08 |
pancreatic cancer | 1.300 | 1.7e-05 |
tuberculosis | -1.800 | 3.0e-04 |
Accession | P29275 |
Symbols |
ADORA2 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
caffeine
pKi 4.77
adenosine
pEC50 4.62
CHEMBL163968
pKi 7.00
CHEMBL217076
pKi 7.00
CHEMBL32150
pKi 7.00
CHEMBL210319
pKi 7.00
CHEMBL199692
pKi 7.00
CHEMBL199280
pKi 7.00
CHEMBL409440
pKi 7.00
CHEMBL1169969
pKi 7.00
CHEMBL212217
pKi 7.00
CHEMBL164281
pKi 7.00
CHEMBL1170168
pKi 7.01
CHEMBL352345
pKi 7.01
CHEMBL445056
pKi 7.02
CHEMBL432273
pKi 7.02
CHEMBL2112067
pKi 7.03
CHEMBL550638
pKi 7.03
CHEMBL604492
pKi 7.03
CHEMBL180236
pKi 7.04
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG 1 - 70 FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTP 71 - 140 FLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVAC 141 - 210 RQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSH 211 - 280 ANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL 281 - 332 //