| Tclin | Adenosine receptor A2b |
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 102 |
| Grant Count | 33 |
| R01 Count | 15 |
| Funding | $5,601,669.47 |
| PubMed Score | 99.17 |
| PubTator Score | 52.58 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.400 | 0.007 |
| medulloblastoma | -2.300 | 0.000 |
| medulloblastoma, large-cell | -1.700 | 0.001 |
| tuberculosis | -1.800 | 0.000 |
| non-small cell lung cancer | 1.208 | 0.000 |
| pancreatic cancer | 1.300 | 0.000 |
caffeine
pKi 4.77
adenosine
pEC50 4.62
theophylline
pKi 5.57
pentoxifylline
pKi 5.29
choline theophyllinate
pKi 5.57
bufylline
pKi 5.57
CHEMBL163968
pKi 7.00
CHEMBL217076
pKi 7.00
CHEMBL32150
pKi 7.00
CHEMBL210319
pKi 7.00
CHEMBL199692
pKi 7.00
CHEMBL199280
pKi 7.00
CHEMBL409440
pKi 7.00
CHEMBL1169969
pKi 7.00
CHEMBL212217
pKi 7.00
CHEMBL164281
pKi 7.00
CHEMBL1170168
pKi 7.01
CHEMBL352345
pKi 7.01
CHEMBL445056
pKi 7.02
CHEMBL432273
pKi 7.02
CHEMBL2112067
pKi 7.03
CHEMBL550638
pKi 7.03
CHEMBL604492
pKi 7.03
CHEMBL180236
pKi 7.04
CHEMBL201447
pKi 7.04
CHEMBL414157
pKi 7.05
| PMID | Text |
|---|---|
| 26748211 | A2B receptor activation is critically required for the stimulatory effect of adenosine on IL-10 production and suppression of nitric oxide release. |
| 26478435 | ADORA2B is a target gene of miR-128b.MiR-128b represses cell proliferation, migration and invasion and promotes apoptosis by targeting ADORA2B in gastric cancer. |
| 26228921 | Data show that ADORA2B mRNA and protein were significantly up-regulated in oral squamous cell carcinoma (OSCC) and that ADORA2B controls cellular proliferation via HIF-1alpha activation, suggesting it may be a key regulator of tumoral progression in OSCCs. |
| 25966978 | the A2B AR activation-driven angiogenesis via cAMP-PKA-CREB mediates VEGF production and PI3K/AKT-dependent upregulation of eNOS in HMEC-1 |
| 25765819 | our data suggest that adenosine A2b signaling represses CIITA transcription in VSMCs by manipulating the interaction between STAT1 and the epigenetic machinery. |
| 25629231 | The rs7208480 of ADORA2B as well as the haplotypes were not found to be associated with chronic heart failure susceptibility. |
| 25587035 | the A2B adenosine receptor (ADORA2B) is essential for adenosine-induced SphK1 activity in human and mouse normal and sickle erythrocytes in vitro |
| 25429616 | Stimulation of A1AR and A2BAR had a prominent anti-proliferative/pro-apoptotic effect on the glioblastoma stem cells. |
| 25087184 | Data indicate adenosine receptor ADORA2B as the specific receptor and signalling pathway for the metabolite 5'-methylthioadenosine (MTA). |
| 25002363 | A2B receptor activation blunts trophoblast migration possibly as a result of reduced activation of the MAPK signaling pathway and lower proMMP-2 levels. |
| More... |
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLG 1 - 70 FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTP 71 - 140 FLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVAC 141 - 210 RQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSH 211 - 280 ANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL 281 - 332 //
| PMID | Year | Title |
|---|---|---|
| 26748211 | 2016 | Up regulation of A2B adenosine receptor on monocytes are crucially required for immune pathogenicity in Indian patients exposed to Leishmania donovani. |
| 26478435 | 2015 | MicroRNA-128b suppresses tumor growth and promotes apoptosis by targeting A2bR in gastric cancer. |
| 26228921 | 2015 | Adenosine A2b receptor promotes progression of human oral cancer. |
| 25966978 | 2015 | Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells. |
| 25765819 | 2015 | A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells. |
| 25629231 | 2015 | The association of ADORA2A and ADORA2B polymorphisms with the risk and severity of chronic heart failure: a case-control study of a northern Chinese population. |
| 25587035 | 2015 | Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity. |
| 25429616 | 2014 | Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy. |
| 25087184 | 2014 | The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma. |
| 25002363 | 2014 | Activation of adenosine A2B receptor impairs properties of trophoblast cells and involves mitogen-activated protein (MAP) kinase signaling. |
| More... |
