Tdark ADGRF4 Adhesion G protein-coupled receptor F4

Protein Summary

Description

Orphan receptor. Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q8IZF3
• B3KTD0
• Q2PNZ0
• Q5T5B5
• Q5T5B6
• Q86SN9
• Q8IXE6

Gene Name

• ADGRF4

Ensembl ID

• ENST00000283303
• ENSP00000283303
• ENSG00000153294
• ENST00000327753
• ENSP00000328319

Symbol

• GPR115
• PGR18
• PGR18
• GPR115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.76
protein domain	0.58
tissue	0.5
gene perturbation	0.44
transcription factor	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Adhesion G Protein-coupled Receptor F4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.92   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.92   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0