Tbio ADARB2 Double-stranded RNA-specific editase B2

Protein Summary

Description

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA. This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NS39
• B2RPJ5
• Q5VUT6
• Q5VW42

Gene Name

• ADARB2

Ensembl ID

• ENST00000381310
• ENSP00000370711
• ENSG00000185736
• ENST00000381312
• ENSP00000370713

Symbol

• ADAR3
• RED2
• RED2
• ADAR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
phenotype	0.8
microRNA	0.74
molecular function	0.63
disease	0.6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Double-stranded Rna-specific Editase B2

Protein / Nucleic Acid Binding / Dna Binding Protein / Double-stranded Rna-specific Editase B2

Protein / Hydrolase / Deaminase / Double-stranded Rna-specific Editase B2

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Double-stranded Rna-specific Editase B2

Protein / Defense/immunity Protein / Double-stranded Rna-specific Editase B2

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Double-stranded Rna-specific Editase B2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.27   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.27   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0