Property Summary

NCBI Gene PubMed Count 17
PubMed Score 6.64
PubTator Score 10.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma 1.078 1.0e-03
subependymal giant cell astrocytoma 2.571 4.0e-02
lung adenocarcinoma 1.200 2.3e-05
inflammatory breast cancer 1.200 9.5e-03

Gene RIF (11)

PMID Text
25863161 Data indicate that ADAMTS2, 3 and 14 cleave the amino-propeptide of fibrillar collagens. [review]
25638164 Suggest the existence of an epigenetic field defect for cancerization disrupting the methylation patterns of several loci, including MGMT or ADAMTS14, that may lead to predictive biomarkers for colorectal cancer in African Americans.
24301791 No significant associations were observed in males. In conclusion, the nsSNP rs4747096 in ADAMTS14 was associated with knee OA in female Thai patients; therefore, the role of ADAMTS14 in OA seems to be gender-dependent.
23491141 Carriage of the ADAMTS14 rs4747096 GG variant appears to delay onset of the injury in Achilles tendon pathology.
22205175 ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20378664 Observational study of gene-disease association. (HuGE Navigator)
18790654 findings implicate ADAMTS14 in osteoarthritis
16385451 Observational study of gene-disease association. (HuGE Navigator)
15913795 Observational study of gene-disease association. (HuGE Navigator)
15913795 This study suggest potentially important role for the ADAMTS14 gene in predisposition to MS.

AA Sequence

MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVV      1 - 70
DTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDF     71 - 140
RELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRRE    141 - 210
AVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHV    211 - 280
QNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHA    281 - 350
EHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETS    351 - 420
LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGY    421 - 490
QTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTK    491 - 560
FGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNA    561 - 630
KHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKAD    631 - 700
DKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKG    701 - 770
KEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNN    771 - 840
VLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV    841 - 910
WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQC    911 - 980
SATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEP    981 - 1050
LHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSP   1051 - 1120
LPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWG   1121 - 1190
WTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT                                        1191 - 1223
//

Text Mined References (18)

PMID Year Title
25863161 The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.
25638164 2015 Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.
24301791 2013 ADAMTS14 gene polymorphism associated with knee osteoarthritis in Thai women.
23728906 2013 A genome-wide association study of sleep habits and insomnia.
23491141 2013 Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.
22205175 2012 Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.
21254220 2011 Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20378664 2010 Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
19851299 2010 Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
18790654 2009 Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
15913795 2005 Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
11867212 2002 Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
11779638 2001 Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family.
11741898 2002 Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.