Property Summary

NCBI Gene PubMed Count 11
PubMed Score 7.94
PubTator Score 10.50

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (22)

Disease log2 FC p
psoriasis 4.300 7.4e-189
cutaneous lupus erythematosus 5.200 3.1e-05
glioblastoma 2.100 8.8e-03
medulloblastoma 1.600 8.2e-04
atypical teratoid / rhabdoid tumor 2.300 1.9e-05
primitive neuroectodermal tumor 2.100 2.3e-02
ulcerative colitis -1.589 3.5e-02
tuberculosis -5.000 1.5e-09
non-small cell lung cancer 2.712 7.5e-13
colon cancer -2.600 1.3e-04
lung cancer 1.600 4.8e-04
sarcoidosis 4.500 1.3e-02
interstitial cystitis 3.900 8.2e-03
lung adenocarcinoma 2.400 2.7e-10
pediatric high grade glioma 1.600 3.6e-03
primary Sjogren syndrome 2.800 1.9e-04
invasive ductal carcinoma 4.000 9.5e-04
breast carcinoma 1.700 1.1e-19
ductal carcinoma in situ 3.500 2.0e-03
ovarian cancer 1.200 5.3e-03
Breast cancer 2.300 2.9e-04
head and neck cancer and chronic obstruc... 2.100 1.2e-02

Gene RIF (6)

PMID Text
25564618 We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors
23754285 ADAMDEC1 functions as an active metalloprotease.
19218196 Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified ADAMDEC1 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
18449420 The ADAMDEC 1 haplotype may indicate an underlying mechanism for high FVIII levels in venous thromboembolism.
18449420 Observational study of gene-disease association. (HuGE Navigator)
12037602 molecular evolution by duplication in a metalloprotease gene cluster on chromosome 8p12

AA Sequence

MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEE      1 - 70
RYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASI     71 - 140
STCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEK    141 - 210
EDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVV    211 - 280
PSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVM    281 - 350
SHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTT    351 - 420
PVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE                        421 - 470
//

Text Mined References (14)

PMID Year Title
25564618 2015 Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
23754285 2013 ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.
19218196 2009 Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.
19139490 2009 A strategy for precise and large scale identification of core fucosylated glycoproteins.
18449420 2008 Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14632642 2003 Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12037602 2002 The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12.
11673514 2001 Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle.
9271581 1997 Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells.