Tchem ADAM9 Disintegrin and metalloproteinase domain-containing protein 9

Protein Summary

Description

Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q13443
• B7ZLN7
• Q10718
• Q8NFM6
• ADAM 9

Gene Name

• ADAM9

Ensembl ID

• ENST00000379917
• ENSP00000369249
• ENSG00000168615
• ENST00000487273
• ENSP00000419446

Symbol

• KIAA0021
• MCMP
• MDC9
• MLTNG
• MCMP
• MDC9
• CORD9
• Mltng

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
protein domain	0.97
molecular function	0.91
disease perturbation	0.9
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 9

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: < 5)

Gene RIFs: 112   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: >= 5)

Gene RIFs: 112   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0