Tchem | Activin receptor type-1B |
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7950 | 1.7e-06 |
malignant mesothelioma | 3232 | 1.1e-05 |
ulcerative colitis | 1819 | 1.6e-05 |
atypical teratoid / rhabdoid tumor | 5112 | 2.6e-05 |
interstitial cystitis | 2312 | 3.9e-04 |
ovarian cancer | 8520 | 5.9e-04 |
glioblastoma | 5792 | 6.8e-04 |
adult high grade glioma | 3801 | 2.6e-03 |
astrocytic glioma | 2597 | 3.5e-03 |
psoriasis | 6694 | 2.4e-02 |
Disease | Target Count |
---|---|
Carcinoma of pancreas | 5 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.100 | 2.6e-03 |
astrocytic glioma | -1.100 | 3.5e-03 |
atypical teratoid / rhabdoid tumor | -1.200 | 2.6e-05 |
glioblastoma | -1.100 | 6.8e-04 |
interstitial cystitis | -1.200 | 3.9e-04 |
malignant mesothelioma | -1.200 | 1.1e-05 |
osteosarcoma | 1.382 | 1.7e-06 |
ovarian cancer | 1.300 | 5.9e-04 |
psoriasis | -1.200 | 2.4e-02 |
ulcerative colitis | -1.300 | 1.6e-05 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA |
CHEMBL492634
pIC50 7.64
CHEMBL3260567
pIC50 7.89
CHEMBL1908395
pKd 8.00
compound 13d [PMID: 23639540]
pIC50 6.49
compound 13r [PMID: 23639540]
pIC50 6.74
galunisertib
pIC50 7.11
vactosertib
pIC50 7.89
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCI 1 - 70 PKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFL 71 - 140 IIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQ 141 - 210 EIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWL 211 - 280 VSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCA 281 - 350 IADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG 351 - 420 GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRI 421 - 490 KKTLSQLSVQEDVKI 491 - 505 //