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Tchem
ACSS2
Acetyl-coenzyme A synthetase, cytoplasmic

Protein Summary
Description
Activates acetate so that it can be used for lipid synthesis or for energy generation. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253382
  • ENSP00000253382
  • ENSG00000131069
  • ENST00000360596
  • ENSP00000353804

Symbol
  • ACAS2
  • ACS
  • ACSA
  • ACAS2
  • ACECS
  • dJ1161H23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
molecular function
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.77
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.92   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.92   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 233
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0