Tclin | Angiotensin-converting enzyme |
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Comments
Property Summary
Ligand Count | 344 |
NCBI Gene PubMed Count | 2,407 |
PubMed Score | 30363.80 |
PubTator Score | 16082.84 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 6.8e-17 |
lung adenocarcinoma | 2716 | 1.1e-10 |
facioscapulohumeral dystrophy | 288 | 4.0e-02 |
Disease | Target Count |
---|---|
Kidney Failure | 111 |
Renal dysplasia | 28 |
Disease | log2 FC | p |
---|---|---|
facioscapulohumeral dystrophy | 1.800 | 4.0e-02 |
lung adenocarcinoma | -1.500 | 1.1e-10 |
non-small cell lung cancer | -1.692 | 6.8e-17 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
enalapril
pIC50 4.30
enalaprilat
pIC50 7.50
trandolapril
pIC50 8.12
ramipril
pKi 8.34
lisinopril
pIC50 8.92
cilazapril
pIC50 8.70
captopril
pKi 8.70
benazepril
pIC50 6.51
spirapril
pIC50 9.10
perindopril
pIC50 8.82
imidapril
pIC50 5.00
delapril
pKi 9.97
zofenopril
pIC50 9.40
quinapril
pIC50 8.08
moexipril
pIC50 8.59
fosinopril
pIC50 9.00
racecadotril
pIC50 6.50
CHEMBL401397
pKi 6.00
CHEMBL290328
pIC50 6.00
CHEMBL558146
pIC50 6.00
CHEMBL398771
pKi 6.02
CHEMBL298827
pIC50 6.07
CHEMBL560685
pIC50 6.08
CHEMBL271224
pKi 6.08
CHEMBL55583
pIC50 6.10
CHEMBL254493
pKi 6.11
CHEMBL254495
pKi 6.13
CHEMBL147755
pIC50 6.14
CHEMBL171850
pIC50 6.15
CHEMBL89547
pIC50 6.16
CHEMBL3037879
pIC50 6.16
CHEMBL85175
pIC50 6.16
CHEMBL404117
pKi 6.16
CHEMBL128223
pIC50 6.19
CHEMBL257229
pKi 6.21
CHEMBL3264007
pIC50 6.23
CHEMBL1907762
pIC50 6.24
MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWA 1 - 70 HDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQY 71 - 140 NALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTAL 141 - 210 SNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAH 211 - 280 LLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEK 281 - 350 PADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAI 351 - 420 GDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNF 421 - 490 DWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIY 491 - 560 RSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHP 561 - 630 PLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKY 631 - 700 GTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDL 701 - 770 TNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLER 771 - 840 LFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAM 841 - 910 LKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNL 911 - 980 EDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDIN 981 - 1050 FLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIP 1051 - 1120 SSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQP 1121 - 1190 NMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQW 1191 - 1260 LLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS 1261 - 1306 //