ACAN
Aggrecan core protein
Protein Summary
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
- ENST00000352105
- ENSP00000341615
- ENSG00000157766
- ENST00000439576
- ENSP00000387356
- ENST00000559004
- ENSP00000453499
- ENST00000561243
- ENSP00000453342
- AGC1
- CSPG1
- MSK16
- AGC1
- SEDK
- AGCAN
- CSPG1
- MSK16
- CSPGCP
- SSOAOD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.8 | ||
phenotype | 0.71 | ||
pathway | 0.66 | ||
cellular component | 0.65 | ||
disease | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3294.19 (req: < 5)
Gene RIFs: 125 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3294.19 (req: >= 5)
Gene RIFs: 125 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0