Tbio ABTB1 Ankyrin repeat and BTB/POZ domain-containing protein 1

Protein Summary

Description

May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes. This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q969K4
• D3DNB0
• Q6ZNU9
• Q71MF1
• Q96S62
• Q96S63

Gene Name

• ABTB1

Ensembl ID

• ENST00000232744
• ENSP00000232744
• ENSG00000114626
• ENST00000453791
• ENSP00000412684
• ENST00000468137
• ENSP00000417366

Symbol

• BPOZ
• BPOZ
• BTB3
• BTBD21
• EF1ABP
• PP2259

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
protein domain	0.73
transcription factor	0.67
tissue sample	0.59
virus perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.76   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.76   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0