Tbio ABHD17C Alpha/beta hydrolase domain-containing protein 17C

Protein Summary

Description

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.

Uniprot Accession IDs

• Q6PCB6
• Q1RMD6
• Q9NPM1
• Abhydrolase domain-containing protein 17C

Gene Name

• ABHD17C

Ensembl ID

• ENST00000258884
• ENSP00000258884
• ENSG00000136379
• ENST00000558464
• ENSP00000452778

Symbol

• FAM108C1
• FAM108C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.9
kinase perturbation	0.81
histone modification site profile	0.73
tissue sample	0.63
transcription factor binding site profile	0.63

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Alpha/beta Hydrolase Domain-containing Protein 17c

Protein / ... / Cysteine Protease / Alpha/beta Hydrolase Domain-containing Protein 17c

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Protein Abhd17c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0