Tchem ABHD12 Monoacylglycerol lipase ABHD12

Protein Summary

Description

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (By similarity). May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways. This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q8N2K0
• A6NED4
• A6NJ90
• A8K450
• B4DE71
• Q5T710
• Q5T711
• Q96CR1
• Q9BX05
• Q9NPX7
• Q9UFV6

Gene Name

• ABHD12

Ensembl ID

• ENST00000339157
• ENSP00000341408
• ENSG00000100997
• ENST00000376542
• ENSP00000365725

Symbol

• C20orf22
• PHARC
• ABHD12A
• BEM46L2
• C20orf22
• dJ965G21.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.71
histone modification site profile	0.67
transcription factor	0.67
transcription factor binding site profile	0.61

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Monoacylglycerol Lipase Abhd12

Protein / ... / Cysteine Protease / Monoacylglycerol Lipase Abhd12

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Monoacylglycerol Lipase Abhd12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.19   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.19   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1