Tbio | Mycophenolic acid acyl-glucuronide esterase, mitochondrial |
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Comments
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2843 | 1.5e-21 |
osteosarcoma | 7950 | 3.1e-04 |
lung cancer | 4740 | 4.1e-04 |
group 4 medulloblastoma | 1855 | 5.3e-04 |
Pick disease | 1894 | 5.6e-04 |
pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.3e-03 |
Waldenstrons macroglobulinemia | 765 | 3.6e-03 |
psoriasis | 6694 | 8.0e-03 |
ovarian cancer | 8520 | 1.1e-02 |
aldosterone-producing adenoma | 665 | 4.8e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Methemoglobinemia | 17 | 4.485 | 2.2 |
Disease | log2 FC | p |
---|---|---|
aldosterone-producing adenoma | -1.038 | 4.8e-02 |
group 4 medulloblastoma | 1.100 | 5.3e-04 |
lung cancer | 1.200 | 4.1e-04 |
lung carcinoma | 1.300 | 1.5e-21 |
osteosarcoma | -1.343 | 3.1e-04 |
ovarian cancer | 1.100 | 1.1e-02 |
pancreatic ductal adenocarcinoma liver m... | -1.091 | 1.3e-03 |
Pick disease | -1.200 | 5.6e-04 |
psoriasis | -1.100 | 8.0e-03 |
Waldenstrons macroglobulinemia | 1.129 | 3.6e-03 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG |
MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNRPDLPNLAYKK 1 - 70 LKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDD 71 - 140 LADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYS 141 - 210 EEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHR 211 - 280 MREKADIQLLVYTIDDLIDKLSTIVN 281 - 306 //