| Tbio | Mycophenolic acid acyl-glucuronide esterase, mitochondrial |
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.5e-21 |
| osteosarcoma | 7950 | 3.1e-04 |
| lung cancer | 4740 | 4.1e-04 |
| group 4 medulloblastoma | 1855 | 5.3e-04 |
| Pick disease | 1894 | 5.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.3e-03 |
| Waldenstrons macroglobulinemia | 765 | 3.6e-03 |
| psoriasis | 6694 | 8.0e-03 |
| ovarian cancer | 8520 | 1.1e-02 |
| aldosterone-producing adenoma | 665 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Methemoglobinemia | 17 | 4.485 | 2.2 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.038 | 4.8e-02 |
| group 4 medulloblastoma | 1.100 | 5.3e-04 |
| lung cancer | 1.200 | 4.1e-04 |
| lung carcinoma | 1.300 | 1.5e-21 |
| osteosarcoma | -1.343 | 3.1e-04 |
| ovarian cancer | 1.100 | 1.1e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.091 | 1.3e-03 |
| Pick disease | -1.200 | 5.6e-04 |
| psoriasis | -1.100 | 8.0e-03 |
| Waldenstrons macroglobulinemia | 1.129 | 3.6e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNRPDLPNLAYKK 1 - 70 LKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDD 71 - 140 LADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYS 141 - 210 EEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHR 211 - 280 MREKADIQLLVYTIDDLIDKLSTIVN 281 - 306 //
