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Tchem
ABCG2
ATP-binding cassette sub-family G member 2

Protein Summary
Description
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237612
  • ENSP00000237612
  • ENSG00000118777
  • ENST00000515655
  • ENSP00000426917

Symbol
  • ABCP
  • BCRP
  • BCRP1
  • MXR
  • MRX
  • MXR
  • ABCP
  • BCRP
  • BMDP
  • MXR1
  • ABC15
  • BCRP1
  • CD338
  • GOUT1
  • MXR-1
  • CDw338
  • UAQTL1
  • EST157481
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
1
disease
0.9
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4276.67   (req: < 5)
Gene RIFs: 833   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4276.67   (req: >= 5)
Gene RIFs: 833   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 658
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6