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Tbio
ABCC6
Multidrug resistance-associated protein 6

Protein Summary
Description
Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205557
  • ENSP00000205557
  • ENSG00000091262
  • ENST00000456970
  • ENSP00000405002
  • ENST00000575728
  • ENSP00000461686
  • ENST00000600761
  • ENSP00000481979
  • ENSG00000275331
  • ENST00000622290
  • ENSP00000483331

Symbol
  • ARA
  • MRP6
  • ARA
  • PXE
  • MLP1
  • MRP6
  • PXE1
  • URG7
  • ABC34
  • GACI2
  • MOATE
  • MOAT-E
  • EST349056
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
disease
0.71
biological term
0.69
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.87   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 406.87   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0