Property Summary

NCBI Gene PubMed Count 1,894
PubMed Score 3760.30
PubTator Score 9526.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 6.15 3.1
Inflammatory bowel disease 142 3.039 1.5
Disease Target Count
Inflammatory bowel disease 13 1

Expression

  Differential Expression (15)

Protein-protein Interaction (3)

MLP Assay (8)

AID Type Active / Inconclusive / Inactive Description
1326 screening 130 / 0 / 193587 High-throughput multiplex screening for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen
1451 screening 18 / 0 / 255 Single point confirmation for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen
1689 confirmatory 9 / 0 / 31 Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen
2833 other 1 / 0 / 14 Chemo Reversal assay in ABCB1-expressing cells for one set of SAR compounds
489002 confirmatory 36 / 0 / 53 Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. Follow-up assay.
504476 other 3 / 0 / 7 Chemo Reversal assay in ABCB1-expressing cells for set2 of SAR compounds
504566 confirmatory 63 / 0 / 4 Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen. Follow-up assay on set 2
504569 confirmatory 59 / 0 / 8 Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. Follow-up assay for Set 2

Gene RIF (2086)

PMID Text
27294449 Imatinib resistance was more frequent in patients with TT genotype at 1236 than in those with CT/CC genotypes. For G2677T and C3435T, resistance was higher for TT genotype when compared to GG/GT and CT/CC but it was not statistically significant.
27045516 An upregulation of P-gp was observed when artemisone and dihydroartemisinin were co-incubated with mefloquine and amodiaquine.
26938523 Findings suggest the presence of an interactive network of proteins namely, ERM and CD44 with P-gp, in breast cancer cells. It also indicates that despite the cancer cells displaying similar or higher amounts of P-gp, disruption of this interaction complex leads to the loss of P-gp drug efflux functionality and the cells acquiring multidrug resistance phenotype.
26895184 Shortening of the ABCB1 3'-UTR causes loss of miRNA-dependent translational control leading to elevated ABCB1 protein levels.
26857783 ABCB1- 3435C>T polymorphism was not associated with irinotecan induced severe toxicities
26857559 The combination of MTHFR, DRD3 and MDR1 polymorphisms associated with a slow ATV metabolizer phenotype
26838221 Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
26829120 nuclear MRP1 is highly associated with better prognosis of human mucoepidermoid carcinoma.
26823873 ABCB1 polymorphisms were associated with the risk for osteonecrosis of the femoral head.
26823755 MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in esophageal squamous cell carcinoma, and enhance tumor progression.
26820614 Data suggest that activities of human ABCB1 and mouse Abcb1a/Mdr1a are unaltered (that is, efflux of fluorescent dyes is unaltered) in chimeric forms created by exchange of homologous transmembrane/nucleotide-binding domains of ABCB1 and Abcb1a/Mdr1a.
26799497 association of SNPs in ABCB1 and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
26784512 ABCB1 3435 CC genotype in donor influences early renal function and creatinine recovery in tacrolimus-treated kidney transplant recipients.
26782761 Twist and P-gp are expressed correlatively in human colorectal cancer specimens
26764117 Data show that tocopherol polyethylene glycol succinate (TPGS)-modified PF127 thermo-sensitive hydrogel was an excellent locally injectable carrier to reverse P-glycoprotein (P-gp) overexpression associated multi-drug resistance.
26757307 The ABCB1 variants modulate therapeutic response to modafinil and may partly explain pharmacoresistance in NT1 patients.
26745103 Elevated expression of ABCB1 gene, through increase in mRNA stability is associated with Gastric Cancer.
26717965 IHC staining of human BCa tissue supported our conclusion that the expression of HIF-1a and MDR1 was higher in chemoresistant tissue vs. chemosensitive tissue.
26715450 Report decreased function MDR1 activity in methotrexate treated rheumatoid arthritis patients.
26704739 The results of this study suggested that the treatment of major depressive disorder can be optimized by ABCB1 genotyping combined with monitoring of plasma drug concentrations.
26704667 Show that monoclonal antibody 15D3 binds to a conformation sensitive epitope of MDR1 that was responsive to membrane cholesterol levels.
26694653 Findings indicated that fetuses of mothers with MDR1 TT genotype may be more susceptible to arsenic toxicity as compared to those of CC or CT genotypes.
26686578 Data suggest that pair of phenylalanine-tyrosine structural motifs in transmembrane region of MDR1/ABCB1 mediate inhibition of ATP hydrolysis by certain drugs (zosuquidar, elacridar, and tariquidar) with high affinity.
26664259 study suggests that C3435T polymorphisms in the ABCB1 gene are strongly associated with a predisposition to depression development, the severity of depressive symptoms and the effectiveness of therapy with using different groups of antidepressant agents
26652611 FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.
26638586 The expressions of p53, Bcl-2, and p-glycoprotein were not significantly correlated with advanced stage, high prognostic scores, ORR, and OS
26632382 NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily.
26625351 P-gp protein is expressed at higher concentrations in chronic rhinosinusitis with nasal polyps as compared to chronic rhinosinusitis.
26604430 results show that GSTT1 null and MDR1 polymorphisms could play a role in susceptibility to inflammatory bowel disease
26601947 In contrast, cytotoxicity of Dp44mT and DpC was potentiated due to more lysosomes containing functional Pgp under glucose-induced stress.
26598078 findings show the multidrug resistance-1 gene C/T polymorphism may be an underlying genetic risk factor for the development of asthma via oxidant-antioxidant imbalance, leading to increased oxidative stress
26595166 The pharmacokinetics of silibinin was significantly influenced by ABCB1 C3435T polymorphism.
26556876 Ceritinib acts as a competitive inhibitor of ABCB1 and ABCG2 to enhance efficacy of antineoplastic agents.
26546461 Data indicate no association was found between genotypes of drug transporters ABCB1, ABCG2, OCT1 genetic polymorphisms and the occurrence of thrombocytopenia.
26535684 the ABCB1 polymorphisms may contribute to osteonecrosis of the femoral head (Meta-Analysis)
26531821 SZuggest ABCB1 genotype may modify the risk of cardiac digoxin toxicity.
26517918 Studies indicate that molecular dynamics (MD) simulations and electron paramagnetic resonance (EPR) spectroscopy can provide structural information on ABC transporters, and information from the two methods is quite complementary.
26517917 Studies indicate that many of the drugs currently used to treat children's brain tumours are substrates for the multi-drug transporter ATP-binding cassette sub-family B member 1 (ABCB1).
26517914 Studies indicate that P-glycoprotein was involved in multi-drug resistance in cancer cells.
26517909 Studies indicate the modelling and molecular dynamics simulation of P-glycoprotein.
26515462 Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity in lung neoplasm xenografts.
26507655 analysis of the tariquidar-binding site in P-gp
26503809 variant allele of 1236C>T and 2677G>T/A displayed significantly higher complete remission
26489634 The SNPs of COMT V108/158M and ABCB1 C3435T significantly influence pain perception in Chinese cancer patients.
26463665 The study provides novel insights on downregulation of ABCB1 expression by TNF-mediated repression of NF-kappaB signaling.
26450467 No association was found between the MDR1 genotype and levels of tacrolimus or its modified formulation in liver transplant patients.
26438079 The evidence from the meta-analysis demonstrated that the ABCB1 C3435T polymorphism may represent a pharmacogenomic biomarker for predicting treatment outcomes in patients on statins. (Meta-analysis)
26421491 polymorphisms in ABCB1 gene may contribute to inter-individual variation in carbamazepine and in CBZ-E transport among patients with epilepsy using CBZ
26400323 we found that patients carrying the CT+CC genotype of ABCB1 C3435T were more likely to have a better neurological outcome when compared with the TT genotype
26381710 The hydrogen bond donor strength is, on average, higher in ABCG2 than in ABCB1, which explains the higher measured affinity of allocrite for ABCG2. pi-pi stacking and pi-cation interactions play additional roles in binding of allocrite to ABCG2 and ABCB1.
26379408 MDR1 gene rs1045642 C > T might confer an increase risk for ulcerative colitis.
26376376 haplotype variants associated with gastrointestinal and aesthetic adverse effects of immunosuppression following kidney transplantation
26362473 The TT genotype of the C3435T polymorphism of the ABCB1 gene and omeprazole usage were each associated with poor clopidogrel responsiveness .
26354214 A positive association was observed between the expression of the ABCB1 and ABCG2 transporter genes (r=0.407, P<0.05) while no association was observed between the expression of either of the ABC transporter genes with the OCT1 gene
26353179 genetic association study in population in Mexico: Data suggest that an SNP in ABCB1 (1236C>T) is not associated with adverse reactions to methotrexate; it protects against myelosuppression in pediatric patients with ALL (acute lymphoblastic leukemia).
26351321 Data show that inhibition of ATP binding cassette subfamily B member 1 (ABCB1) might be a novel therapeutic strategy for non-small cell lung cancer (NSCLC) patients with acquired resistance to proto-oncogene proteins c-met (MET) inhibitors.
26338742 Polymorphism of ABCB1 gene may be a good guide for predicting responsiveness for ondansetron.
26327575 To investigate the relationship between ABCB1 single-nucleotide polymorphisms and the efficacy of salmeterol/fluticasone combination (SFC) inhalation therapy for stable chronic obstructive pulmonary disease (COPD
26319048 In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin
26317651 Data indicate that afatinib reversed ATP binding cassette subfamily B member 1 (ABCB1)-mediated multidrug resistance (MDR) in ABCB1-overexpressing ovarian cancer cells.
26299618 Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp.
26288241 Study showed mRNA expression of MDR1 was up-regulated in 80% of patients with lung cancer and MDR1 TT genotypes had higher risk for the development of the neoplasm.
26281846 MDR1-luciferase reporter mice provided a unique in vivo system to visualize MDR1 CNS expression and regulation.
26278584 Lack of Association between MDR1 G2677T/A Polymorphism and Leukemia Risk: An Updated Meta-Analysis
26261589 MDR1 expression may play an important role in primary hepatocellular carcinoma drug resistance.
26244574 Data suggest that ABCB1 protein and FLT3 protein polymorphisms may be helpful in predicting sunitinib toxicities, response and survival benefit in Asian metastatic renal cell carcinoma (mRCC) patients.
26228923 Genotyping of CYP3A4/MDR1/NR1I2 polymorphisms may be helpful for better guiding tacrolimus dosing in CYP3A5 nonexpressers.
26220385 Meta-analysis indicates that ABCB1 G2677T/A polymorphism may increase the risk of drug-resistant epilepsy in Asians
26219569 Data suggest that MDR1 over-expression is a possible mechanism of acquired resistance to 17-DMAG in lung cancer cells with ALK rearrangement.
26213157 Polymorphisms in ABCG2 rs2231142, rs3114020, HNF4alpha rs2071197 and ABCB1 rs1128503 were found to be associated with LTG CDR.
26211578 Single nucleotide polymorphisms in MDR1 were linked to susceptibility to large B cell lymphoma in Chinese patients.
26208549 The patients with GG genotypes had significantly higher incidence of this complaint[postoperative nausea and vomiting] (p=0.014). Polymorphism of ABCB1 has an association with responsiveness for ondansetron.
26208548 There was significant difference in the genotype frequency of the ABCB1 gene compared to other populations.
26208431 Temozolomide competes for P-glycoprotein binding and contributes to chemoresistance in glioblastoma cells.
26198313 Data from pharmacogenomic studies suggest that SNPs in ABCB1 or CYP1B1 (cytochrome P450 family 1 subfamily B polypeptide 1) are responsible for taxane toxicity when used as chemotherapeutic agent in some women with breast cancer. [REVIEW]
26159621 This study demonstrated that P-gp expression is lower than the group mean in subjects older than 75 years but increased if younger.
26158764 Gal-3 interacts with ATP1A1 and induces the phosphorylation of MDR1, mediating multidrug resistance.
26154535 Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome
26153782 These results indicated that enhanced P-gp expression contributed to the chemoresistance of EBV-positive T-cell lymphoproliferative diseases.
26136502 ABCB1 and ABCG2 transporters protect cancer stem cells from ionophore antibiotics.
26125837 This study showed that MDR1 might have a role in male infertility. Fur-ther research in large cohorts with different populations is required to clarify the role of MDR in male fertility.
26125482 The study observed reproducible transport of two substrates, daunorubicin and verapamil, by an average of 11-12 A through the plane of the membrane as P-GP progressed through a catalytic cycle.
26124005 These results demonstrated that the inhibitory effects of resveratrol on MDR1 expression in HCT116/L-OHP cells were closely associated with the inhibition of NF-kappaB signaling and CREB activation in an AMPK-dependent manner.
26109419 ABCB1 and ABCG2 haplotypes were associated with risk of colorectal cancer.
26107220 ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response.
26086643 P-gp expression in the brain is limited at birth, increases with postnatal maturation, and reaches adult levels at ~3-6 mo of age.
26071279 Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil rheumatoid arthritis
26067842 Suggest the 2677G>A allele of ABCB1 could be associated with simultaneous resistance to rifampin and ethambutol in pulmonary tuberculosis patients.
26062728 butorphanol reversed the ABCB1-mediated Multidrug resistance in leukemia cells by directly suppressing the efflux activity of ABCB1.
26057472 results suggest that the lysosomal degradation system could be targeted to increase the sensitivity of P-gp- expressing cancer cells towards chemotherapeutic drugs.
26045821 We found that the ABCB1 C3435T polymorphism could affect the susceptibility and clinical outcome of colorectal cancer patients.
26026084 It can be concluded that these derivatives show synergism in the presence of doxorubicin and could have potential as ABCB1 inhibitors
26025411 The data demonstrates that RNA interference could down regulate MDR1 gene expression and reduce the p-glycoprotein level, and partially reverse the drug resistance in SW480/OxR cells in vitro.
26006083 Data show that human ABCB1 is a substrate for human NEDD4-1 and identified 8 lysine residues that were ubiquitinated by NEDD4-1.
25997249 hypomethylation of ABCB1 promoter is associated with a decreased response to clopidogrel in ischemic stroke patients via increased ABCB1 mRNA expression
25995454 Casein kinase 2-mediated phosphorylation of Hsp90beta and stabilization of PXR is a key mechanism in the regulation of MDR1 expression.
25989890 ABCB1 polymorphisms may influence the extent of chemotherapy-induced neutropenia in doxorubicin/cyclophosphamide combination-treated patients with breast cancer.
25988710 Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer
25987565 Mutations at the NBD2 transmission interface blocked P-gp assembly.
25987242 The association of rs2032588 with antidepressant side effects suggests the involvement of the ABCB1 genotype in the clinical pharmacology of PGP-dependent antidepressants.
25968898 Conclude that the CBP/beta-catenin complex is a core component of the MDR1 transcriptional "enhancesome" in neoplasms.
25964202 Data show that cosilencing of pyruvate kinase M2 and multidrug resistance gene-1 (PKM-2 and MDR-1) improves the efficacy of paclitaxel against multidrug resistance (MDR) ovarian cancer in a murine model.
25960213 The aim of the study was to examine chemotherapeutic drug binding to MDR1 and the interactions therein.
25959925 In this study, the authors designed bi-functional selenium nanoparticles with specific chirality to deliver siRNA, for targeting tumor MDR1 gene
25940551 the epigenetic modifications of the ABCB1 promoter show high interindividual variability in healthy Chinese subjects, and are closely related to the interindividual variation in ABCB1 mRNA expression
25930120 Cetuximab increases a P-gp substrate intracellular accumulation in both P-gp expressing cell lines, independently of their EGFR expression.
25930089 Pharmacogenetic testing for CYP3A5 and ABCB1 may help make better informed decisions regarding TKI selection for individual patients and limit toxicity while increasing efficacy.
25921280 3435C > T polymorphisms may be associated with susceptibility to acute leukemia.
25921160 p-glycoprotein expression was higher in gastric cancer from elderly patients compared to gastrointestinal tumors from young patients.
25918995 ABCB! polymorphism was associated with adult antisocial behaviors, alcohol dependence, and cocaine dependence, though results did not reach statistical significance.
25908454 Study investigates apoptosis induction in ABCB1-overexpressed cancer cells using c-MET-targeted RNA interference technology in vitro and in vivo.
25885226 Significantly decreased mean MDR1 activity was found in primary colorectal cancer samples compared to normal mucosa.
25869250 the genetic polymorphisms of the cytochrome P450 3A5 gene (CYP3A5) and gene-encoding P-glycoprotein (ABCB1), on the pharmacokinetic parameters of tacrolimus in Chinese adult liver transplant recipients, was investigated.
25861753 our results suggested that the mutant alleles of the MDR1 gene were associated with a significantly increased risk for HCC under all genetic models
25861751 restoring miR-124 may function as a promising strategy to overcome P-gp-mediated MDR by inhibiting FZD5/PKC signaling.
25860377 An update on the role of ABCB1 polymorphisms in drug pharmacokinetics (review).
25854371 C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk childhood acute lymphoblastic leukemia.
25853335 Interactions between ABCB1 and CAV1 with APOL1 may influence allograft failure for transplanted kidneys from African American donors.
25847751 The association of antidepressant treatment outcome and six ABCB1 single nucleotide polymorphisms, was studied.
25846690 study found Thai patients of ABCB1 3435CC genotype and with focal epilepsy were more often phenobarbital resistant
25843201 MDR1 C3435T gene polymorphism is a potential marker of IBD.
25840583 Data indicate that CD30 antigen downregulation and P-Glycoprotein (MDR1) upregulation are associated with drug resistance to brentuximab vedotin.
25823028 CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-kappaB pathway in multidrug-resistant glioblastoma cells.
25816099 meta-analysis demonstrated that effect of C3435T variant on risk of antiepileptic drugs resistance was ethnicity-dependent, which was significant in Caucasians.
25809606 OPRM1 and ABCB1 polymorphisms were significantly associated with administered dose of morphine
25802484 ABCB1 functional activity is affected by TLR4 agonists suggesting that modulation of TLR4 is important in ABCB1 function.
25801244 This study indicated that GQ-ODNs could effectively reverse P-gp-mediated PTX resistance by inhibiting the expression of P-gp and by the co-administration of GQ-ODNs and PTX that could increase the apoptosis
25799371 ABCB1 C3435T polymorphism may be a genetic marker for drug resistance in epilepsy in Caucasian populations.
25791493 The meta-analysis revealed that 3435T allele and ABCB1 2677T/A allele may decrease the risks of Glucocorticoid-induced osteonecrosis of the femoral head .
25788263 Translocation of Cbl-b from the nucleus to the cytoplasm prevented the localization of P-gp to caveolae resulting in the reversal of multidrug resistance through the ubiquitination and degradation of c-Src.
25781547 Authors searched for coding sequence variants in the ABCB1/MDR1 gene in renal transplanted patients treated with Tac
25779097 These findings provide evidence that ganoderenic acid B has the potential to be developed into an ABCB1-mediated multidrug resistance reversal agent.
25778465 The polymorphism of ABCB1 (C3435T) has an important role in the manifestation of toxicities and drug exposure, but not polymorphism of CYP3A5.
25769882 The presence of LKB1 may facilitate increases in either MDR1 or class III beta-tubulin expression.
25761959 This study suggested that the C957T DRD2 polymorphism exerts opposite influences on domain-general frontally mediated reflective learning and striatally mediated reflexive learning.
25760620 These results represent significant advances in the understanding of how P-gp and related transporters bind and export a plethora of metabolites, antibiotics and clinically approved and pipeline drugs
25755800 The CC genotype and C allele of ABCB1 C1236T polymorphisms of ABCB1 are significantly associated with ulcerative colitis susceptibility
25749419 ABCB1 induction via Protein Kinase C induces widespread therapy unresponsiveness in colorectal cancer.
25730063 the T allele carrier of the 3435 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women
25729846 Functional activity of MDR1 is carried out via multiple gene-regulatory mechanisms. (Review)
25725449 Overexpression of MDR1 is associated with drug resistance in uterine sarcoma.
25712653 significant correlation was discovered between gender and C3435T genotype both for IBD and CD patients, with 3435CT heterozygote prevailing in IBD and CD males.
25691056 Polymorphisms in ABCB1, CDA, ENOSF1,and TYMS could help to predict specific and overall severe adverse reactions to capecitabine.
25691007 Data show that inducible nitric oxide synthase (iNOS) is localized in mitochondria of multidrug resistance protein 1 (MDR1)-positive cells.
25673014 The donor ABCB1 3435 genotype influences post-transplant renal function among patients treated with tacrolimus.
25669913 Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study.
25667220 an etiologically relevant interaction between CYP2A13 and ABCB1 associated with lung cancer was analysed
25661341 This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children Acute lymphoblastic leukemia. risk
25661339 The aim of this study was the evaluation of some single nucleotide polymorphisms of genes (ABCB1, SLC28A2/3, SLC29A1) involved in telaprevir (TLV) and ribavirin transport and their correlation with plasma TLV drug exposure at 1 month of therapy.
25656374 Authors detected that resistant cell lines overexpressed ALDH1A3, CD44 and MDR1.
25643948 The expression and functionality of P-gp in corneal tissue can be influenced through time exposure with specific substrates.
25639892 MDR1 plays a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks (review).
25619982 The application of a surface plasmon resonance imaging dual-targeting DNA assay to identify a single nucleotide polymorphism of MDR1 is described.
25616425 There is an urgent need to investigate the role of P-gp-modulating substances as potential sources of drug-drug and drug-food interactions.
25603048 LDL increases ABCB1, ABCC1, and LRP expression in a human doxorubicin-resistant uterine sarcoma cell line.
25596703 ABCB1 was largely the most upregulated gene, which is in accordance with a study in docetaxel-resistant MCF-7 cells, which showed that early induction of docetaxel resistance correlated with combined expression of ABC transporters
25591827 P-gp does not protect cells against beta-amyloid (1-42) toxicity.
25590413 the existence and participation of ABCB1 and the Wnt pathway in an MDR cell line that attenuated proteasome inhibitor-induced apoptosis.
25590378 conditionally immortalized proximal tubule cells with the combined CYP3A5*1/ABCB1 3435TT genotype demonstrated higher tacrolimus disappearance versus cells with a different pharmacogenetic profile
25586345 Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity.
25582575 ABCB1 1199G>A may be a new possible predictive marker for outcome in childhood acute lymphoblastic leukemia
25564970 The present study investigated the time course and dose dependency of the induction of three efflux proteins, P-gp, MRP1 and MRP5, in response to gemcitabine exposure in Capan-2 pancreatic cancer cell line at transcriptional and translational levels.
25560468 These in vitro results suggest that mRNA expression levels of the RRM1 and ABCB1 genes may be useful indicators of chemosensitivity to gemcitabine and cisplatin.
25559283 MDR1 gene polymorphisms 1236T>C, 2677T>G, and 3435T>C may have roles in susceptibility, demographics, pathological characteristics, and therapeutic response to prednisone treatment in children with idiopathic nephrotic syndrome
25558979 ABCB1 influence upon complete remission could not be demonstrated.
25544376 MDR1 was detectable in the PC cell line 22Rv1. However, this study suggests that MDR1 is of less importance for drug resistance in PC cells than in other types of solid cancer.
25544111 The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of glucocorticoid-induced avascular necrosis of the femoral head.
25543520 The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time.
25542807 ABCB1 C3435T plays an important role in intestinal absorption of clopidogrel which further affects the exposure to the active metabolite of clopidogrel and platelet aggregation.
25526204 Results show that MDR1 protein expression is lower in ulcerative colitis patients compared to normal controls and this expression is closely related to the duration of the disease.
25522789 Specific efflux mediated by hPGP or hBCRP can be determined with MDCKII cells where cPgp has been knocked out by zinc finger nucleases.
25521359 the donor CYP3A5*1 allele was significantly associated with a lower vimentin expression. In multivariate analysis, grafts carrying ABCB1 3435T allele(s) developed significantly less EMT and less interstitial fibrosis
25520092 MDR1 gene polymorphism is not associated with childhood acute lymphoblastic leukemia.
25515492 CD44 targeted HA-PEI/HA-PEG nanoparticle platform may be a clinicaly relevant gene delivery system for systemic MDR1 siRNA based anticancer therapies.
25499945 genetic polymorphism is associated with the lipid-lowering efficacy of statin treatment. [meta-analysis]
25498238 These results suggest that inhibiting P-glycoprotein in TECs may be a novel strategy for low-dose chemotherapy targeting TECs.
25495409 The ABCB1 was significantly associated with the CDR . CYP3A4*1G and CYP3A5*3 could influence CBZ metabolism, while POR*28 had no effect on it. The EPHX1 were significantly associated with CBZD:CBZE ratio.
25487678 These findings confirm and extend previous observations that minor alleles of two ABCB1 SNPs predict remission to treatment with substrates in chronic depression
25481101 Upregulated expression of MDR1 might contribute to the intractable nature of pancreatic cancer.
25473899 and enhances the effects of chemotherapeutics in hepatocellular carcinoma (HCC) both in vitro and in vivo
25461681 Multi-walled carbon nanotubes may act on c-Myc to down-regulate ABCB1/ABCC4 expression.
25458099 These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy.
25450670 study provides support for the rationale of combining CUDC-101 with modulators of ABC drug transporters to improve drug efficacy and overcome multidrug resistance associated with the overexpression of ABCB1 and ABCG2
25430046 Our findings show that the presence of ABCB1 3435C>T allele has an impact on CLP pharmacokinetics but not on the drug pharmacodynamics.
25410489 The genetic polymorphism of ABCB1 C3435T might be associated with a longer overall survival in breast cancer.
25404731 Suppressing TrpC5 expression decreased nuclear beta-catenin accumulation, reduced the induction of ABCB1, and reversed 5-fluorouracil neoplastic resistance.
25401518 the Wnt5A signaling pathway was shown to contribute to regulating the drug-resistance protein ABCB1 and beta-catenin-related genes in antagonizing the toxic effects of doxorubicin in cell lines and in clinical breast cancer samples.
25393253 revealed enhanced mRNA levels for multidrug resistance 1 in a CXCL12 rich environment
25388687 Data (including data from studies on cloned Caco-2 cells with transporter genes knocked-out) verify that MDR1, MRP2, and BCRP are responsible for transport of specific xenobiotics (transport of digoxin and erythromycin by MDR1).
25386557 These findings suggest that CH downregulated the expressions of MDR1 mRNA and P-glycoprotein in a time and concentration manner; the mechanism may be mediated via activating c-Jun/JNK pathway.
25355168 No evidence of an association between ABCB1 alleles and CRC occurrence as a whole was found. However, ABCB1 showed either association with carcinoma of the sigmoid colon, and appeared able to influence the sex ratio among CRC patients.
25346426 Polymorphisms of MDR1 are associated with patient's glucocorticoid response and a predisposition to Crohn's disease in Chinese population.
25323158 results strongly suggest that an approach which exclusively relies on a simple correlation between ABCB1 expression
25312789 MDR1 polymorphisms were associated with a requirement for higher warfarin dose for thrombosis.
25311385 Children with GG and GA genotypes of ABCB1 polymorphism rs9282564 had higher risks of RD.
25304659 High MDR1 expression is associated with chemotherapy resistance in gastric cancer.
25301112 ABCB1 snps haplotype were able to predict optimal response to imatinib mesylate in Egyptian chronic myeloid leukemia patients.
25300812 The aim of our study was to assess whether genetic polymorphisms in important genes for warfarin pharmacokinetic and pharmacodynamic such as ABCB1, ABCG2, CYP2C9, and VKORC1 are associated with warfarin stability in patients on long-term therapy.
25273894 Cholesterol-lowering agent ascorbyl phytostanol phosphate but not nanostructured aluminosilicate decreases P-gp mediated drug efflux through decreased mdr-1 gene expression.
25273678 ABCB1 rs1045642 polymorphism is associated with Alzheimer disease risk.
25253429 Taken together, all these results strongly demonstrate that MDR-1 overexpression in K-562 cells could be associated to a MDR phenotype, and moreover, it is also contributing to the platinum and structurally related compound, resistance in these cells.
25251877 Treg cells lack expression of ABCB1, rendering them selectively susceptible to CPA.
25245580 the ABCB1 2677G allele or 3435T allele predicted a worse response to imatinib in CML patients.
25240575 This study aimed to investigate the impact of inter-individual CYP3A4 rs4646437C>T and MDR1 G2677T/A polymorphisms on cyclosporine dose requirements among a sample of renal transplant Egyptian recipients.
25236528 ABCB1 gene polymorphisms at positions 1236, 2677, and 3435 were not related to an increased susceptibility of gastric cancer development. However, they may be associated with the inhibition of gastric cancer progression.
25233417 Data suggest MPR1/ABCB1 (multidrug GPR55 resistance protein 1), (G-protein coupled receptor 55), and ABCC1 (ATP-binding cassette sub-family C) participate/cooperate in autocrine communication/tumorigenesis involving lysophosphatidylinositol. [REVIEW]
25223475 The aim of othis study was to investigate the relationship between C3435T polymorphism of the MDR1 gene and drug resistance in epilepsy.
25218792 neuronal expression of ABCB1 and ABCC1 might be linked to adenosinergic/purinergic neuromodulation
25217066 In ST-elevation myocardial infarction patients treated with clopidogrel after percutaneous coronary intervention, the ABCB1 tag SNP rs1045642 is associated with higher risk of bleedings while rs7779562 is associated with lower bleeding risk.
25205654 miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer.
25177961 Data show that the multidrug resistance 1 gene (MDR1) allele-T and genotype TT may contribute to susceptibility to hepatocellular carcinoma (HCC) in the Chinese Han population.
25173639 we find markedly high expression of P-gp in eyes with retinoblastoma enucleated after chemotherapy.
25172973 ABCB1:c.3435T>C polymorphism may be associated with high-density-lipoprotein-cholesterol response to statin treatment
25169549 Gastric cancer patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.
25162314 ABCB1 genetic variants contribute only little, if any, to interindividual variation of plasma drug concentrations
25155901 ABCB1 1236C>T and 2677G>T may be used as prognostic markers to distinguish relatively high risk patients in the intermediate risk FLT3 wild-type group, which may contribute to future individualizing of treatment strategies.
25145685 P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants
25124867 ABCB1 genetic polymorphisms did not influence the pharmacokinetics of bicalutamide. However, ABCG2 c.421C>A significantly and gene dose-dependently influenced its pharmacokinetics, but c.34G>A did not
25122423 Inherited variation in ABCB1 may affect survival specifically in advanced stage lung cancer patients who receive chemotherapy.
25121365 The response to antiepileptics seems to be modulated by C3435T in ABCB1 or P-gp activity.
25118983 findings provide empirical evidence that ABCB1 C3435T polymorphism may contribute to the risk of MI and ACS, especially among Caucasian populations
25106522 the distribution of the ABCB1, CYP3A5, CYP2C19, and P2RY12 gene polymorphisms distinguishes to the Mexican Mestizos population from other ethnic groups.
25089713 LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance.
25087925 1236 TT in exon 12 in MDR1 gene is associated with risk of chronic myeloid leukemia.
25084202 There was no association between the plasma LDL-C levels and the expression and activity of ABCB1 and OATP1B1
25074866 Results suggest that genetic polymorphisms in MDR1 and RCF1 the toxicity but not the response of methotrexate treatment.
25062490 No associations were found between the MDR1 C3435T polymorphism and clinical-pathological features of the ductal breast carcinoma patients group.
25057852 CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.
25053414 Data indicarte that P-glycoprotein (P-gp) activity was inhibited when P-gp was trapped in an open conformation.
25051717 A marginal association was first shown between the CC genotype of the ABCB1 C3435T polymorphism and the vascular state and histological type.
25040744 KLF8 is involved in hypoxia-induced multidrug resistance through inhibiting apoptosis and increasing the drug release rate by directly regulating MDR1 transcription.
25029804 expression of P-gp, MDR3 and MRP1 may be lower in gestational diabetic pregnancy placentas in comparison to normal placentas.
25015657 MDR1 participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.
25014506 Results show that the risk of developing chronic kidney disease after liver transplantation is not associated with genetic variation in either recipient or donor CYP3A5 or ABCB1 genotype status.
25012726 These findings suggest that ABCB1 gene polymorphisms are associated with antiemetic efficacy of ondansetron in the acute phase after high-dose cytarabine chemotherapy in acute myeloid leukemia patients.
24996541 variants of ABCB1 rs128503, ABCC3 rs4148416, and GSTP1 rs1695 are associated with response to chemotherapy and survival of osteosarcoma patients
24993095 We show that ABCB1 is the functioning ABC transporter in ovarian cancer cell lines, and expression of ABCB1 is associated with a paclitaxel-resistant phenotype
24982363 C3435T polymorphisms of ABCB1 might be able to predict severe amrubicin-induced neutropenia.
24958102 lncRNA MRUL (MDR-related and upregulated lncRNA), located 400 kb downstream of ABCB1, was significantly upregulated in two multidrug-resistant gastric cancer cell sublines, SGC7901/ADR and SGC7901/VCR.
24953225 The analysis showed that there were significantly more cases with the MDR1 3435 CC genotype in the group with drug-resistant epilepsy than in the group with drug-responsive epilepsy.
24950410 A significant association was found between the ABCB1 gene T allele at the polymorphic site 3435 and tramadol dependence. The high frequency of ABCB1 gene T allele present at polymorphic site 3435 could provide protection from tramadol dependence disorder
24933103 Polymorphisms of genes in DNA repair pathway and MDR1 could contribute to chemotherapy response and survival of patients with non-small cell lung cancer.
24919870 genetic polymorphism is associated with acenocoumarol treatment safety in patients with atrial fibrillation or venous thromboembolism
24918524 male carriers of the G allele of variant rs2032582 exhibit greater severity of delusions; however these results should be taken as preliminary and replication studies in other populations of different ethnic origins are required to confirm these findings
24911077 distribution of INR was influenced by variants in CYP4F2 rs2108622, CYP2C9*3, rs9332230, VKORC1 1173C>T, -1639G>A, rs55894764, ABCB1 rs2032582, rs1128503, rs1045642 and F5 rs6025, age, smoking and concomitant drugs
24911075 suggested that C3435T polymorphism in the ABCB1 gene may be an indicator of the susceptibility to major depression
24901645 HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-gp.
24898446 We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group
24896565 In human blood-brain barrier cells the expression of P-gpycoprotein is controlled by a cross-talk between canonical and non-canonical Wnt pathways.
24896362 Studies indicate that ABCB1-transporter P-glycoprotein plays a role in the membrane depolarization, suggesting that constitutive P-glycprotein overexpression in MCD and brain tumors could explain their epileptogeneic properties.
24894670 Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer.
24888374 EGFR-mediated docetaxel resistance occurred through the Akt-dependent ABCB1 expression in prostate cancer cells.
24882106 An investigation of heat shock protein 27 and P-glycoprotein mediated multi-drug resistance in breast cancer using liquid chromatography-tandem mass spectrometry-based targeted proteomics.
24874929 Polymorphisms in the ABCB1 efflux pump are associated with the incidence of dose reductions in metastatic renal cell carcinoma patients treated with sunitinib.
24874456 genes involved in xenobiotic activity, such as ABCB1, had lower expression in the pouchitis and Crohn's disease-like groups compared with the no pouchitis and familial adenomatous polyposis groups.
24855032 Thus low MDR1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone.
24841650 The ABCB1 TT and GSTP1 GG genotypes were significantly associated with a shorter overall survival (OS).
24839009 demonstrates that CD243 gene polymorphism may act as a predisposition factor for breast cancer, particularly in Asian populations
24838898 The multidrug resistance 1 gene polymorphism C3435T is associated with the stricturing phenotype and an inappropriate response to therapy in Crohn's disease. This association with Crohn's disease may support additional pathogenic roles for MDR1.
24815441 This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to gastric cancer and peptic ulcer.
24814288 cell viability and drug pump-out ability were significantly reduced in the FZD1 inhibitor curcumin-treated and FZD1 shRNA-knockdown MES-SA/Dx5 cells, indicating involvement of PKCdelta in FZD1-modulated ABCB1 expression pathway
24810093 ABCB1 related survival difference in ovarian cancer patients.
24804815 ABCB5 and MDR1 gene expression correlate with drug resistance in acute leukemia patients.
24798723 MDR1 C1236T polymorphism might be a risk factor for nonoptimal clinical response to imatinib in Asian chronic myeloid leukemia patients
24796664 overexpression of sorcin increased the phosphorylation of CREB1 and the binding of CREB1 to the CRE sequence of mdr1/p-gp promoter, and induced the expression of MDR1/P-gp
24794827 study supports an association between ABCB1 C3435T polymorphism and resistance to antiepileptic drugs especially in Caucasians, adults, groups treated with various drugs, a '>10 seizures in a year' group based on resistance and a '>/=2 years seizure free' group based on response
24788927 Moreover, P-gp expression was decreased and the apoptosis rate was increased in a concentration-dependent manner following treatment of DATS.
24786296 Our data strongly demonstrated that ER1 was able to increase drug resistance of breast cancer cells through activating MDR1 transcription.
24773260 polymorphisms may affect familial Mediterranean fever susceptibility
24740628 fetal 3435 C>T polymorphism in the ABCB1 gene increases the risk for isolated septal defects in the presence of maternal medication use periconceptionally, particularly for perimembranous VSD.
24734954 Study demonstrates that MDR-1 protein may have a role to play in methotrexate unresponsiveness in rheumatoid arthritis.
24732756 ABCB1, ABCB4 and ABCC2 polymorphisms do not have a role in enhancing risk of drug-induced hepatotoxicity in a Spanish cohort
24717943 increased membranous expression is associated with increased osteitis burden in chronic sinusitis without nasal polyps
24687344 3 SNPs in the coding region (C3435T, C1236T and G2677T/A) have been related to substrate and inhibitor-dependent functional modifications in in vitro studies and reduced expression in tissues. Review.
24682161 The findings of this study suggest that CYP2D6, but not CYP3A5 or ABCB1, play an important role in controlling steady-state plasma concentrations of aripiprazole and its metabolite.
24680847 Dioscin enhanced the intracellular concentration of methotrexate by down-regulating MDR1 expression through a mechanism that involves NF-kappaB signaling pathway inhibition in Caco-2 cells.
24663076 It provides evidence for the potential effect of the ABCB1 genotype on the clinical improvement in children and adolescent patients treated with fluoxetine.
24658440 Studies suggest that P-glycoprotein (P-gp) antagonists could be adopted to revert drug resistance and improve autoimmune diseases outcome.
24647772 Findings suggest that MDR1 expression is decreased when NANOG is knockdown in HepG2 human cells.
24628014 Polymorphisms in ABCB1, CYP3A5, CYP3A4, CYP2C8, and NR1I2 did not affect everolimus inter-individual pharmacokinetic variability.
24621983 the importance of the ABCB1 1199G>A polymorphism for ABCB1 activity
24617050 CD5+ lymphocyte's P-gp1 function was found to be lower in the patients receiving cyclophosphamide in addition to steroids compared to those on steroids only.
24599606 overactivity promotes Th2-associated epithelial cytokine secretion in nasal polyps
24595600 Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2.
24590840 The expression of MDR1, at both mRNA and protein levels, was up-regulated in hippocampus and MTL cortex of mTLE patients compared with the control cortex.
24586633 ABCB1 rs1045642 increases vulnerability to epilepsy with greater tendency for mesial temporal lobe epilepsy with hippocampal sclerosis in south Indian patients.
24582564 Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3).
24581936 There was no significant correlation of single nucleotide polymorphisms of ABCB1 with imatinib mesylate intolerance and induced hepatotoxicity.
24577069 Study suggests that the C3435T polymorphism of the MDR1 gene affects the formation of a depression-prone personality trait in Japanese females
24572589 ABCB1 gene promoter DNA sequence variants may contribute to PD development as a rare risk factor.
24553780 results did not show a significant association between MDR1 C3435T polymorphism and response to anticonvulsant drugs, suggesting that this polymorphism may not be a risk factor to childhood intractable epilepsy (Meta-Analysis)
24549588 extracellular HMGB1 may promote drug resistance to adriamycin and vincristine by upregulating Pgp in human gastric adenocarcinoma cells.
24524306 Data show that multidrug resistance (MDR1) 3435 TT had significantly longer times to major molecular response (MMR) compared to CC/CT genotypes.
24523403 ATPase activity of P-GP increased over 10-fold when the cysteines were cross-linked at distances between 6 and 19 A, although cross-linking at distances greater than 20 A yielded basal levels of activity.
24496564 High MDR1 expression is associated with resistant and relapsed non-Hodgkin lymphoma.
24491996 A role for Trps1 in the regulation of MDR1 expression in osteosarcoma.
24486577 Our findings suggest that ABCB1 polymorphisms, as well as haplotypes derived from C1235T, G2677T/A and C3435T, are associated with inter-individual differences of GCs treatment in ITP.
24472814 MDR1 expression predicts outcome of Ph+ chronic phase CML patients on second-line nilotinib therapy after imatinib failure.
24469730 These findings suggested that rs1045642 SNP of ABCB1 may be associated with the risk of steroid-induced ONFH.
24468132 We suggest that there is an association between cyclin D1 gene amplification and disease severity, unfavorable prognosis, and increased expression of MDR1 in multiple myeloma patients.
24464498 Dihydroxylated xanthonic derivatives were shown to efficiently induce and activate P-gp, affording protection against its toxic substrate, paraquat.
24449364 This meta-analysis indicated that the C3435T polymorphism of MDR1 may not confer susceptibility to IBD.
24448832 Nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides.
24444408 Multivariate analysis of all the studied loci demonstrated that only the CYP3A5*1 (starting from month 1) and CYP3A4*22 alleles (at 3 and 6 months) were independent predictors of Tacrolimus dose-adjusted
24429546 results highlight a novel (patho)physiological role for P-glycoprotein in CD8(+) T cell trafficking into the central nervous system during neuro-inflammation and illustrate CCL2 secretion as a potential link in this mechanism
24395888 MDR1+ Th17 cells may be important mediators of chronic inflammation, particularly in clinical settings of steroid resistant inflammatory disease.
24387690 The C3435T polymorphism of the MDR1 gene is associated with susceptibility to Glucocorticoid-induced avascular necrosis of the femoral head in a Chinese population.
24382439 The leading role in development of resistance of BC cells plays not only PGP, but also MRP1 and BCRP.
24380367 Our data argue against any relevant impact of MGMT, ABCB1 or ABCG2 promoter methylation on overall survival of glioblastoma patients.
24368600 CUL4A and ERK1/2 participated in multi-drug resistance in breast cancer through regulation of MDR1/P-gp expression.
24359561 Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation
24344919 MDR1 downregulation is mainly due to histone post-translational modifications. This occurs concomitantly with aberrant promoter methylation, substantiating the association with P-gp decreased expression.
24340057 Genetic variations in radiation and chemotherapy drug action pathways and survival in locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.
24338387 Association between the ABCB1 G2677T polymorphism and response to Carbamazepine in Malaysian patients with complex partial seizures.
24333728 Knockdown of PP5 and/or PPP2R3C increased ABCB1 expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function.
24329094 conformational transmission from the NBDs to the TMDs in human P-gp
24328528 Detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of coronary heart disease.[meta-analysis]
24326092 There is an association between chemosensitivity and Pgp, GST-pi and Topo II expression in gastric cancer.
24324065 expressions of ABCB1 and ABCG2 genes were regulated through MAPK/ERK and JNK pathways in the human ALL cell lines
24308438 This study was undertaken with a view to determine the allele and genotype frequencies of C3435T and C1236T polymorphisms in the ABCB1 gene among the Maharashtrian population, residing in the Vidarbha region of central India.
24305879 analysis of "silent" MDR1 polymorphisms that significantly change P-gp function; this could be expected to affect interindividual drug disposition and response
24303078 Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance.
24300029 Gene polymorphism C3435T in MDR1 is useful for predicting multidrug resistance in epilepsy patients.
24295377 We conclude that tivozanib at noncytotoxic concentrations has the previously unknown activity of reversing multidrug resistance mediated by ABCB1 and ABCG2 transporters.
24275649 The results show that there is an important hydrophobic network at the IH2/IH3/NBD2 transmission interface that is critical for folding and activity of P-gp.
24268349 Data indicate that FOXO1 upregulates P-glycoprotein (Pgp), and the FLT3-ITD suppresses FOXO1 in acute myeloid leukaemia (AML).
24239898 P-GP may promote the invasion of multidrug resistance (MDR) breast cancer cells by modulating the tyrosine phosphorylation of Anxa2.
24239173 Data indicate that verapamil suppresses MDR1 and survivin expressions and increases Bim expression via suppression of Src activation.
24234588 Phenotype tests for ABCB1 and CYP3A4 did not explain inter-individual variability of sunitinib exposure sufficiently
24223908 Data show that heterogeneity of multidrug resistance (MDR) capaccity driven by ABC (ATP binding cassette) membrane transporters in tumor-initiating cells significantly exceeds that of bulk cells.
24219411 Data suggest positional overlap of binding sites on ABCB1 for substrates (here, Hoechst 33342, daunorubicin) and the inhibitor QZ59 (here as enantiomers QZ59-SSS, QZ59-RRR); overlap appears full for SSS enantiomer, partial for RRR enantiomer.
24213830 MDR1 C3435T and G2677T/A polymorphisms are not associated with antiepileptic drug resistance in Turkish epileptic patients.
24212378 Report transcellular transport studies across Caco-2 cell monolayers with dabigatran etexilate in the presence of various P-gp inhibitors.
24212377 Report impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers.
24210993 P-glycoprotein activity in association with pCrkl reduction levels might help to distinguish between imatinib-resistant and imatinib-sensitive chronic myeloid leukemia cells.
24200053 this is the first report in Caucasian samples to analyze the effect of these ABCB1 genetic polymorphisms on MDD risk
24192121 Our results suggest that ABCB1 polymorphisms might be associated with SSRIs treatment response in the Chinese Han population.
24191517 The results of this study suggest no significant effect of examined C3435T and G2677T/A MDR1 polymorphisms in PE pathogenesis
24190517 MHY412 markedly reduced P-glycoprotein (P-gp) expression and increased apoptotic cell death in MCF-7/Adr cells
24180297 MDR1 gene C3435T polymorphism enacts an important role on colchicine response in familial mediterranean fever patients.
24175826 c.3751G>a genetic variant of MDR1 is associated with hepatocellular carcinoma.
24145140 Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment.
24142546 results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations
24140176 MDR3 is expressed with MDR1 in different cancer cell lines that are resistant to doxorubicin, paclitaxel and vincristine.
24138987 It is the key ABC transporter and its loss of expression or activity may serve as a selective biomarker for capillary cerebral amyloid angiopathy.
24137583 In conclusion, although our results warrant further studies, our data strongly suggest that 99mTc-TF imaging is useful to noninvasively determine the presence of multidrug resistance in patients with breast cancer.
24135937 Reversal of ABCB1-mediated multidrug resistance by Euphorbia factor L1, is not dependent on ABCB1 downregulation.
24116826 results indicate that the c.3073A>C genetic polymorphism of the MDR1 gene is potentially related to the susceptibility to gastric cancer in the Chinese Han population
24107928 This article examines the evidence for clinically relevant interactions between three currently approved tyrosine kinase and ABCB1/ABCG2--{REVIEW}
24088727 AP-1 and NF-kappaB are involved in the P-gp induction in vinblastine resistant Caco-2 cells.
24088131 The TT genotype of the ABCB1 G2677T/A SNP.
24086514 A potential contribution of OPRM1 and ABCB1 single nucleotide polymorphisms to the development of opioid dependence.
24085442 These findings suggested that the c.1465C>T polymorphism of MDR1 may be risk factors for prostate cancer in Chinese men.
24083983 Expression in the presence of cyclosporine A promoted P-glycoprotein maturation.
24083708 ABCB1 rs1128503 TT polymorphism is associated with poor response to chemotherapy in bone tumors.
24070710 MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer.
24064216 Mutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.
24062304 a new mechanism where Pgp-mediated lysosomal sequestration of chemotherapeutics leads to MDR that is amenable to therapeutic exploitation.
24061458 This study proves that P-gp expression is a determinant factor in predicting response to neoadjuvant chemotherapy
24053441 The cysteines in the Walker A motifs in snucleotide-binding domains of P-gp are differentially accessible in the apo and closed conformations.
24042126 Through this meta-analysis for the including studies about the pharmacokinetics of tacrolimus and ABCB1 C3435T SNP, several significant associations were obtained.[meta-analysis]
24040855 MDR1 gene polymorphism C1236T was associated with the anti-allergic effect of fexofenadine among male Jordanians
24034787 The ABCB1 polymorphism may serve as an important factor to guide acute pain therapy in postoperative patients.
24030729 High expression of MDR-1 significantly influenced disease-free survival in acute myeloid leukemia.
24018051 Expression of miR-27a was down-regulated in the multidrug-resistant hepatocellular carcinoma cell line BEL-7402/5-fluorouracil (BEL/5-FU) compared with its parental BEL-7402 cell line, while the MDR1/P-glycoprotein expression was elevated.
24013781 Nuclear MRP1 contributes to multidrug-resistance mainly through regulating MDR1 expression in mucoepidermoid carcinoma.
23996099 A significant association was detected between genetic polymorphisms of ABCB1 and ABCC1 with virological failure of first-line antiretroviral regimens containing protease inhibitors, when controlled by clinical factors, such as sex, age and race.
23994685 C3435T or G2677T/A gene polymorphisms are risk factors of increased susceptibility, earlier onset of nephrotic syndrome, and steroid resistance.
23987116 The current meta-analysis indicates that pesticide-induced gene mutations may contribute to increasing susceptibility to Parkinson disease, especially in the GSTP1, SLC6A3, and MDR1 genes.[meta-analysis]
23984379 The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in MDR1 gene and pharmacoresistant epilepsy.
23977225 Low ABCB1 mRNA levels are an early event in colorectal cancer development.
23962445 ABCB1 and ABCG2 mediate cancer drug resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1.
23953328 Immunoblots detected MDR-1 in all oocytes, with the greatest accumulation in the geminal vesicle stage.
23948418 The expressions of MDR-1, RRM-1, EGFR, ERCC-1 were observed in a variety of pathological types of NSCLC.
23941826 Results indicate that Yg-3-46a has the potential to evade drug resistance mediated by P-gp and beta-III tubulin overexpression.
23931269 Imipramine is a transported substrate of human P-gp.
23930592 genotypic and haplotypic frequencies of the three most common single-nucleotide polymorphisms in the MDR1 gene
23926124 Polymorphism of the ABCB1 gene is associated with chronic kidney disease and hypertension. The ABCB1 C3435T polymorphism might predict CKD, especially in the elderly.
23925666 There are no significant differences in the allelic and genotypic frequencies between breast cancer patients and cancer-free controls.
23917396 Cur-NPs triggered the intrinsic apoptotic pathway through regulating the function of multiple drug resistance protein 1 (MDR1) and the production of reactive oxygen species (ROS) in CAR cells.
23917080 Our study has not identified additional signals, or validated reported associations between epithelial ovarian cancer progression and survival and ABCB1 SNPs rs1128503, rs2032582, and rs1045642.
23907215 The upregulation of MDR1 was found to be involved in the drug-resistant properties of cancer cells.
23896815 ABCB1, ABCC1, and ABCC2 single nucleotide polymorphisms are associated with Glasgow Outcome Scale (GOS) score after traumatic brain injury.
23893241 A miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer.
23880209 The results of this study suggested that antidepressant treatment of depression can be optimized by the clinical application of ABCB1 genotyping.
23874772 C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in a Han Chinese population when the mothers are exposed to phthalates and alkylphenolic compounds during the periconceptional period, particularly for septal defects
23872171 C3435T polymorphism of MDR1 gene is not associated with warfarin resistance.
23861346 study identified ABCB1 gene upregulation as a common mechanism involved in acquired docetaxel resistance in prostate cancer
23859045 The expression level of MDR1 gene was significantly elevated with eclipta alba extracts in HepG2 cells.
23828747 This study suggests a protective role for the MDR1 3435 C/C versus MDR1 3435 T/Tgenotype and C versus T allele for the progression of IBD in this cohort.
23827160 CYT387 was efficiently transported by both human MDR1 and BCRP, and very efficiently by mouse Bcrp1 and its transport could be inhibited by specific MDR1 inhibitor, zosuquidar and/or specific BCRP inhibitor, Ko143.
23822562 Activation of Wnt/beta-catenin pathway resulted in upregulation of P-glycoprotein & contributed to multidrug resistance of QBC939/5-FU cells.
23820292 result from forensic cases suggests that ABCB1 polymorphisms are associated with an increased risk for completed suicides
23816407 There is no association between MDR1 C3435T and G2677T/A polymorphisms and the risk of coronary artery disease in Turkish patients.
23805980 MDR1 mRNA expression may be considered as a potential marker for response to chemotherapy in acute myeloid leukaemia patients. [Meta-analysis]
23803106 MDR1 3435 C>T gene polymorphism is associated with differentiated thyroid cancers.
23803084 ABCB1 genetic polymorphism is associated with the development of colorectal cancer.
23803057 This study failed to reveal any signifiant difference in 24 h opioids doses among the subjects carrying various ABCB1 C3435T phenotypes.
23801278 Association analyses indicated that these two MDR1 SNPs were statistically associated with the increased risk of gastric cancer
23799853 cell membrane expression of MRP-1 or loss of exon 9 is predictive of outcome in Ewing's sarcoma family of tumours but not the number of splicing events or expression of Pgp
23790363 Data suggest ABCB1 is highly expressed in 1st trimester placenta as compared to 2nd/3rd trimesters; varying oxygen tension appears to regulate gene expression of ABCG2 (breast cancer resistance protein; but not ABCB1) in placental villous explants.
23786015 Single nucleotide polymorphisms in ABCB1 and SCN1A genes significantly correlate with drug resistance to antiepileptic agents in patients with epilepsy.
23783165 Mothers carrying at least one copy of the ABCB1 2677 T variant had an increased risk of experiencing sedation.
23775025 variation in ABCB1 gene is not associated with treatment response in breast cancer.
23771260 we discuss the biological factors influencing the safety and efficacy of the humanized mAb hP67.6 linked to the potent cytotoxic drug calicheamicingamma1 (gemtuzumab ozogamicin) that target CD33 cell surface antigen expressed on AML cells--{REVIEW}
23771194 Study showed that genetic variation in the ABCB1 gene might play a role in the risk of switching and discontinuation of antidepressant therapy but the clinical relevance is limited.
23771192 Demonstrate that the TT genotype at position 2677 in the ABCB1 gene is associated with adverse drug reactions to osmotic-release oral system-methylphenidate.
23759256 the c.1465C>T variant is not significantly associated with breast cancer susceptibility in the studied populations
23756537 MDR1 gene polymorphism is not associated with gingival hyperplasia frequency, but may be associated with disease severity.
23748364 Variation in the donor apolipoprotein L1 (APOL1), caveolin 1 (CAV1), and multi-drug resistance 1 encoding P-glycoprotein genes (ABCB1) are all associated with graft survival after kidney transplantation. [Review]
23746184 The ABCB1 polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis after oxaliplatin-based chemotherapy for CRC patients
23744557 Vinblastine resistance in renal cell carcinoma can be ascribed to the overexpression of P-gp, which is regulated by the activation of the PI3K/Akt pathway and triggered by upstream CCN1-integrin avb3 interaction.
23743668 This effect on tacrolimus pharmacodynamics was associated with ABCB1 3435C>T SNP in renal transplant patients.
23741405 P-gp is unlikely to contribute to the pathogenesis of refractory epilepsy through transport of carbamazepine or lamotrigine.
23740681 Results suggest that MDR1 allelic variation may influence plasma levels of quetiapine.
23733192 Data indicate that utations in intracellular helices (IHs) IH2 but not IH1 inhibit maturation of P-glycoprotein (P-gp).
23731124 This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia
23725642 These findings demonstrate, for the first time, that the polymorphisms in (exon 12) 1236 codon of the MDR1 gene greatly influence the drug response in patients iwth breast cancer.
23720091 The functional G1199A ABCB1 polymorphism might be of a potential prognostic value in renal transplanted patients.
23717663 Genetic association between single nucleotide polymorphisms in the ABCB1 and ABCC2 genes and treatment outcome in Malaysians with complex partial seizures on treatment with carbamazepine.
23707158 Significant association was seen for ABCB1 1236C>T polymorphism with treatment responsein breast cancer.
23690617 Data indicate that ATP-Binding Cassette transporter P-glycoprotein (P-gp) exists in an equilibrium between different states, readily interconverted by ligand binding.
23690268 No significant differences in the MDR1 genotypic and allelic frequencies between BC patients and cancer-free controls.
23684483 Data suggest that MDR-1 C3435T may have a protective effect against myelodysplastic syndromes (MDS) progression.
23683876 Data suggest that determination of MDR1 gene polymorphisms (G2677T) might be useful in response prediction to therapy with imatinib in patients with chronic myeloid leukemia (CML).
23677641 Amongst patients with chronic rhinosinusitis without nasal polyps, P-gp is overexpressed in those with high tissue eosinophilia, and correlates with severity of radiographic inflammation.
23666532 ABCB1 C3435T polymorphism and first course-docetaxel exposure may be predictive factors of pathological response and may be able to guide individualized therapy in breast cancer patients.
23634976 The Glu256-Arg276 salt bridge was critical for P-gp folding.
23619510 No effect of the triple single nucleotide polymorphisms variant of P-gp on molecular transport of digoxin or imatinib was observed.
23600489 Under basal conditions, Sav1866 revealed a lower catalytic efficiency and concomitantly a more pronounced sodium chloride and pH dependence than P-glycoprotein.
23593196 efficient, reliable, and simple high-throughput assay has identified ABCB1 substrates/inhibitors that may influence drug potency or drug-drug interactions and predict multidrug resistance in clinical treatment
23564211 Study provides evidence that the P-gp transporter is involved in central antihistamine effects in humans.
23562850 silencing mediator for retinoid and thyroid receptors (SMRT) may affect steroid and xenobiotic receptor(SXR)-mediated transcription on xenobiotic-response enhancer module (XREM) of MDR1 promoter even in the presence of rifampicin
23559630 Transintestinal cholesterol excretion is operative in jejunal explants and is regulated by PCSK9/ABCB1/statins.
23557865 In Korean gynecologic patients, no association was found between ABCB1 genetic polymorphisms and postoperative fentanyl consumption.
23556446 Our results support the hypothesis that ABCB1 and possibly other ABC-transporters are involved in the process of Abeta accumulation in the aging brain
23556337 With respect to ABCB1 G2677T/A, non-G carriers had higher peak plasma concentration and AUC of pitavastatin acid, and Cmax of pitavastatin lactone
23546964 Data suggest that MDR1 gene variants in the Jordanian population will be useful for investigations on response to P-glycoprotein substrate.
23546954 Data indicate that the association between ABCB1 methylation status and gene expression in established cancer cell lines shows that this method is accurate and reliable.
23542036 Independently of EAPP, E2F1 also increases the activity of the MDR1 promoter.
23537364 Our results confirm the role of MDR1 in both Crohn Disease and especially in Ulcerative Colitis pathogenesis although the overall influence of MDR1 variants on disease susceptibility is modest.
23532266 The c.335T>C and c.3073A>C polymorphisms of the MDR1 gene were associated with the risk of occurrence of hepatocellular carcinoma in the Chinese Han population.
23528223 MDR1 1236T, MDR1 3435T and PXR 63396T alleles showed a frequency of ~50%.
23520057 P-glycoprotein participates in modulation of epithelial secretion of lipopolysaccharide stimulated interleukin 6, granulocyte macrophage colony stimulating factor, and thymic stromal lymphopoietin
23515680 ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram.
23504525 C3435T polymorphism of ABCB1 gene is not associated with colorectal cancer.
23503472 The dose-adjusted trough concentration (C0) of cyclosporine in ABCB1 2677 TT carriers was significantly higher.
23494858 Down-regulation of c-fos by shRNA sensitizes adriamycin-resistant MCF-7/ADR cells to chemotherapeutic agents via P-glycoprotein inhibition and apoptosis augmentation.
23490381 Hepatitis C virus NS5A protein caused down-regulation of mdr1 and up-regulation of bcrp expression in Huh7 cells.
23488625 The c.1465C > T MDR1 single nucleotide polymorphisms increased the hepatocellular carcinoma risk in all genetic models.
23484165 The main mechanisms of drug resistance were due to P-gp expression in the doxorubicin, vincristine, and paclitaxel resistant cell lines and BCRP expression in the topotecan resistant cell line.
23478574 Egr-1 accumulation activates MDR1 transcription, thereby inducing the drug resistance observed in paclitaxel-resistant breast cancer cells.
23471840 Curcuminoids suppressed preferentially the growth of SW-480 and HT-29 compared to CCD-18Co cells and enhanced the anticancer activity of the chemotherapeutic drug 5-fluorouracil due to the suppression of MDR1.
23469685 ABCB! is a determinant of inter-subject variability in rosuvastatin pharmacokinetics in healthy Chinese volunteers
23465586 result does not support any significant association between the MDR1 polymorphism and drug-resistant childhood epilepsy
23465077 These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
23463283 CacyBP enhances multidrug resistance of pancreatic cancer cells by regulation of P-gp and Bcl-2.
23443122 These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 and MRP3, which may be enhanced by the simultaneous use of both drugs.
23443032 NSOC risk is determined by fetal and not maternal ABCB1 genotype.
23435914 Menadione can exert its chemosensitizing effect by competitively inhibiting P-gp-mediated extrusion of anti-cancer drugs.
23425635 this study identified no change in placental P-gp following antenatal glucocorticoids, it has provided evidence that P-gp plays an important role in cases of small for gestational age infants
23422925 Quercetin significantly induced the activity of P-glycoprotein/MDR1 in healthy Chinese subjects.
23408444 No significant relationship was found between colchicine doses that would introduce optimal clinical response and affect the therapeutic dose and CYP3A4 and MDR1 gene polymorphisms in these Familial Mediterranean Fever patients.
23407853 genetic association study in healthy subjects in Colorado: Data suggest that sitagliptin pharmacokinetics do not differ due to 3 SNPs in ABCB1 (rs1128503, rs2032582, rs1045642); further, atorvastatin has no effect on pharmacokinetics of sitagliptin.
23406767 Report no significant differences in ABCB1 polymorphism frequency between controls and breast cancer patients in Poland.
23402298 The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported.
23385102 Coma is associated with fentanyl and midazolam exposure; delirium is unrelated to midazolam and may be linked to inflammatory statuS
23369096 Data suggest overexpression of ABCB1--and other membrane efflux pumps that transport various antineoplastic agents out of cell--plays major role in multidrug resistance in cancer; thus, ABCB1 is potential target for antineoplastic therapies. [REVIEW]
23364775 CYP2C19/ABCB1 genotype may modify cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents.
23364483 CYP3A5 and ABCB1 genetic polymorphisms affect the pharmacokinetics and pharmacodynamics of tacrolimus and its metabolites
23361102 OATP1B1 phenotype is more important than CYP3A4 and MDR1 phenotypes for the individual pharmacokinetic variability of atorvastatin.
23358260 The ABCB1 2677 TT genotype group showed significantly lower rates of complete control of acute emesis than the group with GG genotypes (p = 0.045). No significant association with complete response was found for 3435C>T (p = 0.190)
23356581 Significant association between ABCB1 rs1128503 and sexual dysfunction in women receiving a PGP substrate SSRI.
23354914 The data show for the first time that ABCB1 is a target gene of PITX2 transcriptional activity, promoting multidrug resistance and cell survival of cancer cells.
23349819 Data indicate that the down-regulation of p38 mitogen-activated protein kinase by siRNA neither affected the expression of ABCB1 nor the cytotoxic effect of paclitaxel on epidermoid carcinoma cell line KBv200.
23339364 These results suggest that follicular dendritic cells induce MDR1 expression in reactive as well as neoplastic B-cells
23328208 the posttranslational and transcriptional mechanisms underlying stimulation of Pgp function and expression by keratinocyte growth factor-2 (KGF2) that may contribute to the beneficial effects of KGF2 in intestinal inflammatory disorders
23317199 MDR1 gene polymorphisms is associated with susceptibility to hepatocellular carcinoma.
23307242 Results from this study suggested that c.3073A > C polymorphism in the MDR! gene was not associated with the susceptibility to breast cancer in the studied population
23298861 p-gp is expressed at the apical membrane of AB cells of mouse, monkey, and human leptomeninges
23291714 EZH2 depletion leads to suppressed MDR1 mRNA expression in hepatocellular carcinoma cells.
23280016 MDR1 expression in primary tumors was highly correlated with in corresponding lymph node metastases
23279665 There is some evidence to indicate an association between ABCB1 rs1045642T and colorectal cancer risk in Asians. Combined haplotypes might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians.
23272163 SLC22A1-ABCB1 haplotypes may influence IM pharmacokinetics in Asian CML patients.
23261390 P-glycoprotein is fully active after multiple tryptophan substitutions
23252945 Idarubicin yielded a higher CR rate than daunorubicin in high MDR1 expressers.
23244145 MDR1 C3435T polymorphism is responsible for oral mucositis in children with acute lymphoblastic leukemia.
23240156 Polymorphism of ABCB1 and ABCG2 genes encoding drug transporters and their investigation by pyrosequencing
23216707 ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients.
23210244 The findings of this study will be of some relevance in predicting MDR1 phenotype and pharmacokinetics as well as pharmacodynamic effects of many commonly used drugs that are P-gp substrates
23193993 ABCB1 transporter gene polymorphism was statistically significantly associated with colorectal cancer risk.
23188198 ABCB1 polymorphisms are associated with different antidepressant dosages to achieve remission in major depressive disorder.
23178631 TRAIL may reduce the expression of drug-resistant genes MDR1, LRP and GST-pi, thereby participating in the reversion of the multidrug resistance of gastric cancer.
23174593 The expression of MDR1 gene in cancer stem cells is related to the molecular subtypes of breast cancer tissue.
23169446 Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.
23163129 The fetal ABCB1/C3435T gene polymorphism may contribute to risk for cardiovascular diseases in later life.
23161145 Our results show an association of C(3435)T allele of mdr1 with hypertension and with blood pressure levels in resistant hypertensive subjects
23158821 3435C-->T polymorphism in the MDR1 gene may be a genetic susceptibility factor for childhood acute lymphocytic leukemia.
23152970 The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
23146479 ABCB1 genotype was not a determinant of tacrolimus dose requirement and did not influence the development of posttransplant diabetes.
23134497 [review] Increased cerebral Pgp function follows prolonged seizures and as a mechanism contributing to drug resistance in refractory epilepsy.
23133566 Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues
23131698 genetic association studies in population in Paris: Data suggest that SNPs in ABCB1 (rs1045642) and CYP3A5 (rs776746) are not associated with pharmacokinetics of everolimus in heart transplant recipients.
23117931 5alpha-androstane-3beta,17beta-diol decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells
23109454 The presence of the polymorphic allele T of MDR1 gene is related to increased expression of Pgp protein in patients with hepatocellular carcinoma.
23107770 Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients.
23088763 the MDR1 T-129C polymorphism is associated with the risk of DLBCL and the MDR1 G2677T/A and T3435C polymorphisms are associated with survival in DLBCL in a population from southern China.
23085402 the functioning of ABCB1 as an efflux pump does not depend on actin, which is due to its distribution in both cell surface-localized non-raft membrane areas and lipid raft domains
23082557 ABCB-1 C3435T polymorphisms do not affect plasma nevirapine and efavirenz concentrations in HIV/TB co-infected Thai patients or their immunological outcome, but had an effect on virologic outcome in the nevirapine-treated group.
23073467 ABCB1 and Il-10 polymorphisms were found to be associated with lipid responses to sirolimus treatment in renal transplant recipients.
23069916 In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression
23064017 kidney donor CC genotype at C3435T (rs1045642) within ABCB1, a variant known to alter protein expression, was associated with an increased risk for long-term kidney graft failure compared with non-CC genotype
23056288 evidence from our meta-analysis indicated that the ABCB1 C3435T polymorphism might be a risk factor for the MACE in patients on clopidogrel LD 300 mg, and that TT homozygotes decreased the outcome of bleeding compared with CC homozygotes
23053935 Common haplotype frequencies in the MDR1 locus in Saudi Arabian males differs from that of other ethnic groups.
23050008 The systematic characterization of gene-wide common quantitative trait loci associated with ABCB1 mRNA expression in normal liver tissues would provide the candidate markers to ABCB1-relevant clinical phenotypes in Chinese population.
23047249 The expressions of MDR1 and ABCG2 in liposarcoma and synovial sarcoma cells are significantly downregulated by dehydrocostus lactone.
23035695 In rodent and human brain capillary endothelial cells, P-gp expression is under the direct control of 1alpha,25-dihydroxyvitamin D3-liganded vitamin D receptor (VDR).
23034269 Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma
22972536 Correlations between lamotrigine concentrations and ABCB1 C1236T variants.
22971641 results suggest that the C3435T polymorphism may not play an important role in Parkinson's disease susceptibility in Japanese
22946104 Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1.
22941809 CYP2C9*3(1075A>C), MDR1 C3435T and MDR1 G2677T/A were determinants of inter-subject variability in fluvastatin pharmacokinetics in healthy Chinese volunteers
22932088 The results indicated that platinum-based chemotherapy sensitivity was significantly associated with polymorphism of ERCC1 C118T and MDR1 C3435T SNP.
22927901 clitocine could reverse P-gp associated MDR via down-regulation of NF-kappaB
22925562 Immunohistochemical detection of the expression of MDR1 and wild-type p53 at the time of diagnosis might assist in choosing specific chemotherapeutics to improve prognosis and therapy.
22922069 Data suggest that ABCB1, ABCC2, and ABCC5 are up-regulated in placenta/cytotrophoblasts in response to spontaneous syncytialization or glucocorticoids; in contrast, nuclear NR3C1 is down-regulated under these influences.
22910404 Genetic variation in ABCB1 may be associated with P300 amplitude in patients with schizophrenia.
22909202 The study suggests that a priori knowledge of ABCB1 genotypes can provide a significant input into evaluating the patient's response to medication, and minimizing redundant dosing and refractoriness.
22907429 HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1
22906996 ABCB1 polymorphisms are associated with response to therapy in HER2-positive metastatic breast cancer.
22902647 population genetic studies in Jiangsu Han population of China: Data suggest that frequency distribution of 3 SNPs in MDR1 in Jiangsu Han population are close to those in populations in Japan and Malay and far from those in populations in Europe.
22901208 overexpression of MRP1 is associated with relapse in childhood acute lymphoblastic leukemia.
22886152 ABCB1 polymorphisms may be helpful in predicting certain cyclosporine-related side effects in renal transplant recipients.
22883199 The expression levels of hOCT1 and ABCB1 vary in different disease states of chronic myelocytic leukemia patients on imatinib mesylate therapy. These two genes may influence the time from first complete cytogenetic remission.
22845311 Data indicate that imatinib and nilotinib appear to be transported by ABCB1 but do not interact strongly with ABCG2.
22842366 Knockdown of MDR1 expression is associated with the increase of sensitivity of ovarian cancer cells to chemotherapeutic agents vincristine, paclitaxel and docetaxel
22835948 donor age and ABCB1 1199G>A polymorphism affect long-term renal function after transplantation
22823957 These results suggest, for the first time, that the Wnt/beta-catenin pathway regulates ABCB1 in CML.
22819965 Data suggest that the regulation of MDR1 expression by ETS2 may provide potential ways to overcome MDR in cancer treatment.
22819074 Overexpression of MDR1 is associated with multidrug-resistance in multiple myeloma.
22814029 This is the first evidence that CB(2) and TRPV(1) receptors cooperate to modulate MDR1 expression.
22810051 CC genotype of MDR1 gene is associated with response to therapy in ischemic stroke.
22800348 The overexpression of ABCB1 and the down-regulation of ABCG2 in FaDu/T cells were the main features of multidrug resistance in hypopharyngeal carcinomas.
22798502 ABCB1 expression is limited to endothelial cells, whereas ABCC1 expression could mark a minority of tumor cells approaching a stem-like status.
22796246 ABCB1 C3435T genetic polymorphism alters methotrexate pharmacokinetics Korean hematopoietic stem cell transplant patients.
22788927 P-glycoprotein expression is induced by H. pylori infection in the upper GI tract and the TT genotype appeared to have a significantly lower P-gp expression compared with the CC genotype in the stomach.
22766400 analysis of MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer
22761669 Polymorphisms in MDR1 gene is associated with response to therapy in non small cell lung cancer.
22751348 P-gp behaves as an oncofetal protein that, by cross-talking with Bcl-xL, acts as an anti-apoptotic agent in Helicobacter pylori-related gastric carcinogenesis.
22739506 Magnitude and duration of norbuprenorphine-induced antinociception is significantly increased in mdr1 knock-out mice compared to controls.
22705826 this study showed that MDR1 genes and their polymorphisms may affect a patient's BD susceptibility and colchicine response.
22700974 results suggest that trapping P-gp in a conformation in which the NBDs are closely associated likely mimics the structural rearrangements caused by binding of drug substrates that stimulate ATPase activity
22691950 Inhibitory effect of phospholipids on P-glycoprotein: cellular studies in Caco-2, MDCKII mdr1 and MDCKII wildtype cells and P-gp ATPase activity measurements.
22683872 Elevated ABCB1 expression decreases bacterial attachment to gastrointestinal tumor epithelial cell line.
22680342 Influence of .... ABCB1 SNPs on nevirapine plasma concentrations in Burundese HIV-positive patients
22664042 ABCB1 gene overexpression may be associated with a poor prognosis in adults with acute leukemia.
22661185 The C3435T polymorphism of the ABCB1/MDR1 gene is not a risk factor for inflammatory bowel disease in the population coming from central Poland.
22647192 Transitions between well-established ABC transporter conformations have been studied using targeted molecular dynamics in attempts to assemble a series of conformational changes that reflect structural changes required for catalysis.
22641402 No correlation was observed between the C3435T polymorphism of the MDR1 gene and gastric neoplasm.
22641028 We conclude that adverse drug effects with SSRI treatment, in particular serotonergic effects, are predicted by two common polymorphisms of the ABCB1 gene.
22641027 Initial plasma PTH levels were higher than expected (69 mg l(-1); normal range: 10-20 mg l(-1)), and the patient was homozygous for the CYP2C9*2 allele, heterozygous for the CYP2C19*4 allele and homozygous for the 3435C and 1236C ABCB1 alleles
22632055 Altered the expression levels of ABCB1 and ABCG2.
22623266 Combined ABCB1 3435C>T and CYP2D6*10 genotypes had a significant (P < 0.01) effect on the fraction of metabolite absorbed from the depot.
22614869 miR-130a may be associated with MDR1/P-gp-mediated drug resistance and plays the role of an intermediate in drug-resistance pathways of PI3K/Akt/PTEN/mTOR and ABC superfamily drug transporters in SKOV3/CIS cells.
22610055 among our pediatric patients with Idiopathic nephrotic syndrome the C1236T polymorphism in the ABCB1 gene was associated with steroid resistance
22606322 Among epilepsy patients, there is a tendency for higher seizure frequency group to have higher basal MDR1 level (p = 0.059). The MDR1 conformational change level was significantly higher in the high-medication-use group than the low-use group (p = 0.028).
22591177 Data indicate significantly higher expression of MDR-1 mRNA in either BM or PB samples of patients who did not harbor FLT3-ITD, compared to patients harboring this mutation.
22574520 Report synthesis of 5-arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump ABCB1.
22545578 These results suggested that upregulation of P-gp is involved in the increased paclitaxel resistance but not cisplatin resistance in ionization radiationinduced human esophageal squamous cancer radioresistant cells.
22543673 Data indicate that patients carrying the ABCB1 G2677T/A TT + TA + AA genotypes or the 2677T/A-3435T haplotype had a longer progression-free survival (Cox regression, P = 0.052, 0.037 and 0.037, respectively).
22526155 Results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
22521463 P-GP and breast cancer resistance protein expression increase in spinal cords of amyotrophic lateral sclerosis patients.
22515119 No significant association between severe toxicities and ABCB1 polymorphisms in non-small cell lung carcinoma patients treated with gefitinib.
22491935 Neratinib stimulated the ATPase activity of ABCB1 at low concentrations but inhibited it at high concentrations.
22484209 Vandetanib reverse resistance to doxorubicin by inhibiting the functionality of P-gp.
22473764 study characterized genetic variability of the ABCB1 (also known as MDR1), ABCC2 (MRP2) and ABCG2 (BCRP) genes, which are key players in the metabolism of many chemotherapeutic agents including those used in the treatment of lung cancer
22462752 the ABCB1 1236TT-2677TT-3435TT genotype was associated with higher plasma concentration and the risk of developing higher toxicity in patients with non-small-cell lung cancertreated with erlotinib
22460269 The HCT116 human colon cancer cells with mutant beta-catenin showed high ABCB1 promoter activity and expression.
22434582 no association was seen between P-glycoprotein expression and single nucleotide polymorphisms within ABCB1 although a nonsignificant reduction in activity was demonstrated for rs1045642
22428763 MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy.
22409848 Cox-2 might be involved in the multidrug resistance of hepatocellular carcinoma mediated by P-gp.
22398969 A genetic model combining the maternal risk genotypes in CYP2D6 and ABCB1 is significantly associated with adverse outcomes of codeine in infants and their mothers.
22396794 ABCB1 gene polymorphisms play at best a minor role in the susceptibility to colorectal cancer
22395309 The expressions of the cancer stem cell markers ABCB1, ABCG2, and CD133 increased with increases in the degree of differentiation in the human gastric adenocarcinomas.
22394004 The expression of the MDR1 gene showed a significant increase in colorectal cancer regions compared to adjacent normal tissue.
22369694 This study does not support a critical role of the CYP450 or ABCB1 single nucleotide polymorphisms in the occurrence of toxicity or acute rejection in renal transplant recipients treated with tacrolimus.
22363694 iNOS induction plays a novel role in decreased p-glycoprotein expression and transport function.
22358302 Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for MDR1 C3435T polymorphism and cancer were estimated.
22358301 Polymorphisms in the ABCB1 gene and the levels of Pgp expression could be useful to identify prognostic in AML patients.
22344233 Studies indicate a molecular network that coordinates genetic and epigenetic events leading to the activation of ABCB1.
22320423 Our data suggest that repeated exposure to chemotherapy may result in deregulated histone acetylation genome-wide and in the MDR1 promoter.
22318545 The distribution of TPMT, UGT1A1 and MDR1 gene polymorphisms of the South Indian population was significantly different from other populations.
22311042 results suggested that the MDR1 C3435T polymorphism may contribute to cancer risk
22310591 ABCB1 polymorphisms were not associated with tacrolimus concentrations among Korean renal transplant recipients.
22307172 P-gp is expressed in the mitochondria of MCF-7 cells and has an efflux function.
22306099 The results of this study suggested that the T3435 allele or carrying two copies of this allele confers susceptibility to major depressive disorder in the Japanese population.
22298798 no association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting
22296372 Overall response to chemotherapy in the eligible 103 patients was 21.4%. Patients with C/C genotype in MDR1 codon 3435 had a significantly higher response rate (24.5%) than those for C/T(19.0%) and T/T(12.5%) (P<0.05).
22277678 ABCB1 gene polymorphisms may predict clinical responses to fentanyl in cancer patients being converted to the transdermal system.
22272278 Findings show that the gene expression of ATP-dependent efflux transporters MRP1, -3, -4, -5, and p-gp fluctuated during stem cell-derived retinal pigment epithelial cells (hESC-RPE) maturation.
22258826 this is the first report of molecular interaction of any Schiff's base metal chelate CuNG with human P-gp. This information may be useful to design more efficacious nontoxic metal-based drugs as MDR-reversing agents
22242821 Results suggest that in the clinical use of gemtuzumab ozogamicin (GO, inducible MDR-1 expression in tumor cells should be investigated before treatment with GO.
22239287 MDR1 C3435T gene polymorphism plays a role in seizure occurence and phenytoin absorption.
22236186 in B-chronic lymphocytic leukemia patients, the 2677GT genotype was associated with higher advanced glycation end product levels; C3435T MDR1 polymorphism showed higher values of advanced oxidation protein products with respect to heterozygous genotype
22228759 new mechanistic evidences for the extragenetic emergence of MDR in cancer cells and indicate that new treatment strategies designed to overcome MDR may include inhibition of both microparticles and Tunneling nanotube-mediated intercellular P-gp transfers.
22223515 MDR1/P-gp is overexpressed in the epithelial layer of sinus mucosa in chronic rhinosinusitis patients both with and without nasal polyposis.
22209339 Meta-analysis failed to show an association between the ABCB1 C3435T polymorphism and risk of overall recurrent ischemic events, stent thrombosis or bleeding in clopidogrel treated patients.
22206665 ETS1 promotes paclitaxel resistance and invasion in part by up-regulating MDR1 and MMP9 expression.
22203729 Data show that PGP and ERCC1 were significantly upregulated in recurrent lesions from patients with advanced stage ovarian serous carcinoma.
22199281 Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein
22194207 Genotype and haplotype analyses of the MDR1 gene in 142 Familial Mediterranean fever patients and 130 unrelated Turkish subjects, is reported.
22190510 Expression of CapG, gelsolin, and P-gp was found to be associated with an increased risk of death from non-small cell lung cancer.
22184139 Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
22182917 Polymorphisms in ABCB1 are associated with multiple myeloma.
22178260 We found that the frequencies of polymorphisms and haplotypes of ABCB1, SLCO1B1 and ABCC2 were similar in patients with ATD-induced hepatitis and ATD-tolerant controls
22177087 An evaluation of the association of C3435T polymorphism of MDR1 gene with aspirin resistance in stroke subtypes finds a significant association of TT genotype in intracranial large artery atherosclerosis, the worst clinical outcome.
22160574 MDR1 C3435T polymorphism cannot be considered as a reliable predictor of response to chemotherapy in patients with advanced breast cancer.
22155850 Results showed that MDR1 2677 mutant homozygotes were prone to develop side effects but might achieve prolonged survival.
22153531 Increased and adjusted clopidogrel loading dose according to platelet reactivity monitoring attenuated clopidogrel resistance in carriers of ABCB1 mutant allele.
22152775 Zhizhen Recipe-medicated sera downregulated NFKB and P-glycoprotein in human colorectal cancer multidrug-resistant cell line HCT-8/VCR.
22136368 genotype and haplotype distributions are highly variable among populations of the same self-reported colour and geographical region
22135187 Genetic variants in ABCB1, TGFB1, and XRCC1 appear to be associated with susceptibility to hepatitis A virus infection among Mexican Americans.
22134106 The ABCB1 1236CT/2677GT/3435CT haplotype is positively associated with the major molecular response to IM in CML patients.
22129893 The expression of p53 and XRCC1 protein was equal, but lower compared to MDR1, both testing positive in 36% of all tissue samples.
22118813 ABCB1 can occasionally cause anticancer drug-resistance in breast cancer patients
22112610 Study examined associations between functional variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes in patients with epithelial ovarian/primary peritoneal cancer (EOC/PPC) following platinum and taxane-based chemotherapy.
22110582 the association between the C/D ratios of tacrolimus and the haplotypes of MDR1 gene
22104130 The ABCB1 3435C>T, ABCB1 2677G>A/T, and MTHFR 1298A>C polymorphisms influenced the efficacy of methotrexate monotherapy in Japanese rheumatoid arthritis patients.
22088099 The MDR1 C3435T variant may modify the susceptibility to leukemia.
22087845 The TT genotype and the mutated allele T for the polymorphisms 1236 and 2677 could increase peptic ulcer risk.
22070651 Single Nucleotide Polymorphisms in MDR1 results in increase in Interleukin 22 plasma concentration and associated with multidrug resistance in B-chronic lymphocytic leukemia.
22062654 Study generated transporter protein P-gp fused with the S-peptide of ribonuclease for use as standard in immunoquantification in human liver and small intestine.
22041778 There was no significant difference in the relative P-pg mRNA levels among patients with multidrug resistant tuberculosis and controls.
22040961 Expressions of ABCB1, BMI-1, HOXB4 were not detected in the patients with non-malignant hematologic diseases, but were higher in de novo acute leukemia patients and lower in patients in complete remission.
22037714 MDR1, MRP1 and BCL-2 have potential clinical relevance in adult patients with acute leukemia in the context of induction chemotherapy.
22033938 variations in the C3435T gene play an important role in the pathogenesis of infantile spasms in the Han Chinese population; 3435TT is associated with increased risk of having this epilepsy syndrome.
22028772 the mass action elementary rate constants for P-gp's transport and functional characterization of members of P-gp's network
22028352 This case-control study identified 3 genes (CYP2C19, ABCB1, and ITGB3) and 2 clopidogrel-related factors (loading dose and proton pump inhibitors) that were independently associated with early stent thrombosis
22027393 Report ability hydroxyethyl cellulose-cysteamine conjugates of various degrees of thiolation to inhibit P-glycoprotein.
22016816 effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy
22007612 Loss-of-function polymorphism of the CYP2C19 gene, but not the ABCB1 C3435T and CYP3A5*3 genes, affects the antiplatelet effect of triple antiplatelet therapy.
22001987 C3435T ABCB1 SNP is not a major factor for genetic susceptibility to peptic ulcer, but in a group of men who suffered from peptic ulcer, this polymorphism seemed to be a risk factor for H. pylori infection development
21999196 Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.
21991360 A support vector machine (SVM) method was developed to predict P-gp substrates and P-gp-substrate interactions, based on a training data set of 197 known P-gp substrates and non-substrates collected from the literature.
21987299 Variants in the ABCB1 gene is associated with corticosteroid dependence in children with Crohn's disease
21982686 1st describption of C3435T polymorphism in 2 patients with Charcot-Marie-Tooth disease.
21965597 We discovered a novel nongenetic basis to multiple drug resistance whereby microparticles (MPs) transfer P-gp intercellularly from MDR donor cells to drug-sensitive recipient cells.
21956451 ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP expression correlated with pancreatic cancer tumorigenesis and drug resistance in a mechanism that is independent of promoter methylation
21955855 Variants in the drug transporter ABCB1 gene are possibly associated with the neutrophil suppressing effect of paclitaxel in patients with ovarian cancer.
21947347 C3435T MDR1 gene polymorphism may not be related with the rheumatoid arthritis (RA) susceptibility, but may influence the efficacy of RA therapy with DMARDs, and the 3435CC genotype may be related with refractory RA.
21940367 Pancreatic tumor cells with the wild type SNPs of MDR1 showed drug resistance, but we were not able to confirm a remarkable effect of the anti-MDR1 antibody.
21937435 Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2
21918980 tested the hypothesis that common polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes could be implicated in lymphoma risk. We selected 68 SNPs in the four genes, and we genotyped them in 1,481 lymphoma cases and 1,491 controls
21917707 Both omega-3 and omega-6 PUFAs modulate expression of MDR1 and increase apoptosis in Caco2 cells.
21916909 abcb1 polymorphisms did not affect the tacrolimus PharmakoKinetics
21902503 These observations suggest a potential influence of ABCB1 polymorphisms in oseltamivir-related NPAE, maybe as a result of an enhanced permeability of the blood-brain barrier to oseltamivir
21896346 CYP3A5 +6986AA genotype was correlated with a high blood cyclosporine concentration, lack of the MDR1 +1236CC genotype in both the donor and recipient was correlated with less TRM and a longer OS in patients who received allogeneic HSCT.
21888455 Most of the non-Hodgkin's lymphoma patients have alterations on the chromosome arms 1p, 6q, 7q, 20q, 22q, and Xp.
21887726 More evidence is needed to draw safe conclusions regarding the association of MDR1 variants and development of inflammatory bowel disease.
21868524 siRNA down-regulated MDR1 mRNA expression by 50% in breast carcinoma and osteosarcoma cell lines, and inhibited tumor cell proliferation up to 90%, when co-administered with doxorubicin or methotrexate, despite the known chemoresistance of the cell lines
21864659 Gemifloxacin is effluxed by both P-gp and MRP2. Long term exposure induced their gene expression and functional activity.
21857092 The genotype frequency of the analyzed MDR1 SNPs in a Serbian population was as follows: 3435 nt - 0.19 (CC), 0.54 (CT) and 0.27 (TT); 2677 nt - 0.26 (GG), 0.52 (GT), 0.15 (TT), 0.03 (GA) and 0.064 (TA), and 1236 nt - 0.23 (CC), 0.61 (CT) and 0.16 (TT
21851848 This study investigated the effects of diverse commonly used plant natural products on the expression and activity of P-gp in human adenocarcinoma cells.
21851199 MDR1 gene polymorphism is associated with colchicine resistance in nonresponder familial mediterranean fever patients during the common therapy protocol.
21840870 CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and vomiting in patients treated with ondansetron and metoclopramide.
21839244 In heart transplantation, patients treated with cyclosporine showed a clear effect of the ABCB1 SNPs rs1045652, 1128503, and 2032582 on corrected trough drug concentrations in the first 4 months.
21829205 Results suggest that ABCB1 is primarily responsible for mediating MDR in SLK cells selected with either HIV-PIs alone or in combination with doxorubicin.
21827803 For the MDR1 C3435T SNP, a significant association with objective response was detected for CC genotype in overall and Asian populations stratified
21827403 It is now clear that both BCRP and P-gp are important elements of blood brain barrier function and their expression and transport activity are regulated by distinct signaling pathways
21826700 Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation
21826689 Allelic frequencies of functionally important ABCB1 variant C3435T in the Hungarian population are similar to that of other Caucasian populations.
21806387 Neither ABCB1 nor PON-1 genotypes significantly influenced platelet reactivity or outcome.
21806386 Our analyses revealed no significant association of ABCB1 genotypes or haplotypes with interpatient variability of TAC or CSA C0/dose in
21784846 HSF-1 inhibition and depletion of Hsp27 is a trigger, at least in part, for the accumulation of transcriptionally active mutant p53, which can either directly or NF-kappaB-dependently induce an MDR1/P-gp phenotype in MCF-7 cells.
21781495 Doxorubicin up-regulated the expression of mdr1 in K562 cells.
21781437 No evidence of association between ABCB1 polymorphisms and cleft lip or palate was detected
21780830 investigation of vectorial transport across enterocytes: Data from Caco-2 cell, models for intestinal absorption, suggest that OATP2B1 mediates apical uptake of fexofenadine/zwitterion and that P- glycoprotein acts to attenuate such uptake.
21743379 There was no statistically significant association between LPV or RTV AUC or CL, and CYP3A5, ABCB1, or SLCO1B1 A388G polymorphisms.
21721528 Data show that NSC73306 demonstrated MDR1-selectivity against all P-gp-expressing cell lines examined.
21718764 Data show there were no significant differences in age, gender, and pre- and post-treatment platelet counts between CC, CT, and TT genotypes of the MDR1 gene.
21707071 SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels
21705081 Single nucleotide polymorphisms in ABCB1 gene is associated with Multidrug resistance in plasma cell myeloma.
21704032 Results describe the structure of anti-MDR1 siRNA destabilized by mismatches in its central region, and investigate the influence of the nucleotide substitutions upon its silencing activity.
21698374 CYP3A5 genotype may explain variation in tacrolimus (TAC) disposition early after transplant in pediatric kidney recipients, independent of age; whilst, in pediatric liver recipients, variation in TAC disposition appears related to age and ABCB1 genotype
21636342 Iranian adult female patients with a C/C genotype at position 3435 of the ABCB1 gene have a higher risk of resistance to antiepileptic drugs.
21630164 In the present study, after treatment of gemcitabine-resistant cells with cyclopamine, down-regulation of Gli-1, ABCB1 and ABCG2 was observed.
21619790 Subjects carrying MDR1 3435 T/T genotype may have a higher risk of benzene poisoning.
21618519 Data show that the let-7 (let-7d and let-7g) target IMP-1 stabilizes the mRNA of MDR1.
21599592 Data show that CD45+CD19- MCL-ICs play a role in the drug resistance of MCL, and this drug resistance was largely due to quiescent properties with enriched ABC transporters.
21589866 the genetic polymorphisms of CYP3A5, CYP2B6, CYP2C9, CYP2C19, and ABCB1 examined did not influence methadone dosage. A small influence of CYP2D6 genetic polymorphism in methadone doses and plasma concentrations was found
21575142 ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
21566283 The mdr-1/P-gp expression was decreased, and gammaH2AX expression was upregulated in heat-and neferine-treated MCF7 cells.
21553324 We have investigated single nucleotide polymorphisms of the MDR1 and MIF (G-173C, rs755622) genes in 170 children with nephrotic syndrome
21544031 Renal expression and localization of CYP3A5 but not P-gp is associated with the occurrence of calcineurin inhibitor nephrotoxicity.
21538355 Report diminished intestinal p-glycoprotein function at pH4.5
21530324 Our findings suggest that the ABCB1 rs3789243 C>T, C1236T, G2677T/A, rs6949448 C>T, and C3435T haplotypes do not contribute to response to anticonvulsant treatment in epilepsy.
21525574 sIL2R and MDR1gene expression levels as early predictors of steroid resistance in nephrotic syndrome for early control of disease by immediate introduction of cytotoxic drugs.
21520403 Pgp expression was more frequently observed in early chronic (P = 0.00) and in advanced (P = 0.02) chronic myeloid leukemia phases when it was compared to MRP1 expression
21520073 These results revealed that Cl-IB-MECA induced an increase in expression of TRAIL receptors in K562 cells, which could sensitize cells to apoptosis induction via an extrinsic cell death pathway.
21518489 Tetrandrine can inhibit the expression of YB-1 and up-regulate the expression of c-Jun, which inhibits the expression of MDR1 gene in K562 cells.
21518320 Inhibition of P-gp facilitated glycosaminoglycan accumulation via hyaluronan export inhibition during chondrogenic differentiation of human bone marrow-mesenchymal stem cells.
21517853 Activation of pregnane X receptor and constitutive androstane receptor by their respective ligands leads to P-glycoprotein induction at both mRNA and protein levels.
21508398 Overexpression of MDR1 is associated with poor response to paclitaxel-based lung cancer chemoradiation.
21493161 The results of this study suggested that ABCB1 3435-TT is associated with decreased plasma levels in Chinese patients with epilepsy.
21478475 we investigated a possible association between 2 common ABCB1 polymorphisms, Alzheimer disease, and cerebrospinal fluid (CSF) levels of amyloid-beta. No strong evidence for association was found.
21463115 Data show there was no correlation between the MDR1 genotypes and Binet stage, unmutated immunoglobulin heavy-chain variable region (IGHV) status, CD38 expression, ZAP-70 expression, and p53 deletion.
21460357 Patients with nephrotic syndrome carrying homozygous mutants of MDR-1 single nucleotide polymorphism (SNP) G2677T/A are prone to develop steroid-resistance nephotic syndrome
21452853 ABCB1 is inhibited by 5'-fluorosulfonylbenzoyl 5'-adenosine through its interaction with both drug-substrate-and nucleotide-binding sites
21449914 The peak serum concentration and area under the serum concentration-time curves were significantly different among the ABCB1 3435C>T genotypes in CYP2D6*10/*10.
21445698 An association between ABCB1 haplotype and plasma fasting LDL cholesterol concentration was found in patients with advanced heart failure. This association was not seen 1 year after cardiac transplantation.
21438836 association between ABCB1 or PXR expression in PBMCs and lipid or apolipoprotein plasma concentrations were not significant in this subset of healthy subjects
21436775 Tacrolimus dose-adjusted C0 was larger in CYP3A5*3 and CYP3AP1 non-expressing renal transplant patients than in those who expressed the genes. Also, wild-type homozygotes for MDR1 C3435T had a slightly lower dose-adjusted C0 compared with heterozygotes.
21434577 there were marked ethnic differences in the mutant frequencies of CYP3A5*3 and MDR1 among Chinese ethnic groups
21420937 The three polymorphisms in the ABCB1 gene were not found to be significantly associated with drug resistant epilepsy in a western Chinese pediatric population.
21392722 the relationship between 1) genotype and Atorvastatin efficacy and 2) genotype and myalgia
21391884 [review] Meta-analysis of 23 studies (7067 patients) shows no significant association of ABCB1 alleles, genotypes and haplotypes with the response to treatment in the overall population or in each ethnicity subgroup.
21389634 MDR1 transports a large number of structurally unrelated drugs and is involved in their pharmacokinetics, and thus is a key factor in drug interaction. (Review)
21388909 Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to valproic acid in patients with epilepsy.
21383334 Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain
21380926 inhibition of the GCS gene affects the expression of MDR1 mRNA and P-gp function.
21375937 PKCalpha inhibitor chelerythrine can reverse multidrug resistance in breast carcinoma cells by inhibiting the expression of MDR1 in vitro.
21366702 P-glycoprotein (ABCB1) is strongly expressed within sweat ducts, vessels, nerve sheaths and muscles of human skin and moderately expressed in basal epidermis.
21350189 Suggest that Lactobacilli or their soluble factors stimulate P-gp expression and function under normal and inflammatory conditions.
21336967 mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells, SK-HEP-1 cells, MiHa cells, and furthermore, induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells.
21325069 Data identified loss of p16 and upregulation of MDR-1 at protein level with chromosomal translocation in the established cell lines.
21321274 The present method can readily be used to screen new-compound transport by P-gp or BCRP, even before any radiolabeling.
21321273 Avoiding barriers to PET radioligand development: cellular assays of brain efflux transporters.
21317201 ABCB1 genes may contribute to sex steroid-mediated effects on colorectal cancer development.
21316663 Overexpression of multidrug resistance protein 1 inhibited chemotherapy-induced toxicity of granulosa cells.
21316268 There is no association between ABCB1 and PXR polymorphisms and their haplotypes, and interaction between them, with response to monotherapy treatment of epilepsy in Chinese, Indian, and Malay subgroups.
21308736 Results showed that EFL1 did not downregulate expression of ABCB1 either in mRNA or protein level.
21292509 Data indicate there were no statistical changes in the genotype distribution of GSTM1, MDR1 C3435T, and VEGF A2578C gene polymorphisms were observed between cases and controls.
21247447 Inter-ethnic differences in the ABCB1 and CYP2C19 variant allele frequencies exist in the Brazilian general population plus Amerindians. This information could help in designing more cost effective programs for individualizing clopidogrel therapy.
21243282 preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.
21237140 SNaPshot assay for the CYP3A5 and MDR1 five polymorphisms detection was accurate, automated, and cost-effective
21218380 ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behcet's disease
21186402 In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
21185600 Genetic polymorphisms of the MDR1 is associated with the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia
21183698 Polymorphisms in the multidrug resistance gene ABCB1 is associated with molecular resistance in patients with newly diagnosed chronic myeloid leukemia receiving high-dose imatinib
21182301 Suppressor W232R(TM4/TMD1)of P-glycoprotein rescued mutants with processing mutations in any domain and restored domain interactions.
21173786 Despite not knowing patients' CYP2D6 genotype, clinicians intuitively modify risperidone dosage in order to obtain the best therapeutic option.
21163067 The expression of III beta-tubulin and MDR1 may play an important role in the development and progression of human non-small cell lung cancer.
21154157 Studies indicate that polymorphisms in the drug transporters ABCB1 and ABCG2 are associated with altered pharmacokinetics and varying responses to tyrosine kinase inhibitors
21148080 investigation of substrate specificity of MDR1: endoxifen is transported by recombinant MDR1
21148022 Suggest that ABCB1 genetic polymorphisms may be a predictive marker of quetiapine treatment in schizophrenia.
21143841 MDR1 was not observed in chordoma
21133625 In conclusion, these results suggested that the MDR1 TT genotype might influence risk of development of acute lympoblastic leukemia and the CC genotype might be linked to a poor prognosis of ALL.
21106724 Certain commonly inherited polymorphisms in ABCB1 may serve as markers for QT prolongation following the administration of ABCB1-substrate drugs.
21103977 Review: Digoxin and talinolol are suitable in vivo probe drugs for intestinal ABCB1.
21103972 genetic polymorphism and functional consequences of genetic variations (Review)
21094796 MDR1 polymorphisms did not affect pharmacokinetics of tacrolimus in Chinese renal transplant recipients.
21094057 None of the ABCB1 variants or haplotypes were associated with estimated Glomerular Filtration Rate after heart transplantation.
21079659 The association of T129C and T1236C single-nucleotide polymorphisms (SNP) of ABCB1 gene with drug-resistant epilepsy in Iranian epileptics, was studied.
21079659 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21076384 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21072184 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21072155 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21063774 Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.
21063774 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21057378 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21056987 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21047545 levels of capillary P-gp may contribute to Alzheimer disease lesion development
21047202 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21042729 P-gp can be an effective target for enhancing short-chain ceramide cytotoxicity in the treatment of drug-resistant cancer.
21039333 review focuses on genetic polymorphisms of ABCB1 and ABCC2 and critically analyses important publications dealing with the influence of ABCB1 and/or ABCC2 polymorphisms on drug disposition [review]
21029698 P-glycoprotein function in peripheral blood cells is associated with primary multidrug resistance in breast carcinoma.
21028964 examined the impact of nucleotide mismatches and the number and location of 2'-O-methyl modifications on the silencing activity and nuclease resistance of anti-MDR1 siRNAs
20980337 Knockdown of MyoD and PEA3 attenuated MDR1 expression and increased the sensitivity of multidrug resistant cancer cells to cytotoxic drugs that were transported by P-gp in SGC7901/VCR cells.
20970643 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20970628 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20970601 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20970553 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20959500 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20959405 Observational study of gene-disease association. (HuGE Navigator)
20955690 These data suggest the existence of APAP-induced stimulation of MDR1 transcription in the intestinal epithelium.
20945045 Visfatin may down-regulate the ABCA1 expression and up-regulate the ACAT1 expression via PPARgamma signal transduction pathway, which decreases the outflow of free cholesterol, increases the content of cholesterol esters, and then induces foam cell formation.
20944127 ABCB1 G2677T/A and ABCB1 C3435T gene polymorphisms were not found to be associated with prognosis in Caucasian women with ovarian cancer.
20944127 Observational study of gene-disease association. (HuGE Navigator)
20938465 Patients with ABCB1 1236C/C or 2677G/G genotypes showed poorer survival than patients with other genotypes. Both these genotypes were significant factors for survival in multivariate analysis
20938465 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20933082 Ingestion of garlic extract increased expression of duodenal P-glycoprotein to 131% (95% CI, 105-163%), without increasing the expression of cytochrome P450 3A4 which amounted to 87% (95% CI, 67-112%), relative to baseline in both cases.
20931330 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20929136 Changweiqing could reverse the drug resistance of colon cancer cells by influencing nuclear translocation of YB-1 and reducing the expression of MDR1/P-gp.
20922799 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20921883 Increased expression of MDR-1 is associated with brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer.
20881953 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20869436 Combined treatment with the UIC2 antibody and P-glycoprotein modulators can completely block the function of P-glycoprotein in human ovarian carcinoma cells.
20862566 Up-regulation of P-glycoprotein expression was associated with decreased apoptosis but not with changes in proliferation in laryngeal squamous cell carcinoma.
20860463 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20859246 Findings suggest that single nucleotide polymorphisms in the ABCB1 gene may be a indicator of the severity of depression.
20859246 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20856196 we show, to the best of our knowledge, for the first time that APE1 is stably associated with the basic transcription factor RNA polymerase II (RNA pol II) and the coactivator p300 on the endogenous MDR1 promoter
20855224 Although the frequency of the -7833C>T substitution in MDR1 is relatively low, the SNP is crucial because it may alter the pharmacokinetics of P-gp substrates in a small subset of the population.
20844484 Thyroid abnormalities can significantly effect the expression of P-glycoprotein, thereby altering the disposition and action of drugs that are substrates of P-glycoprotein.
20843132 Genetic polymorphisms in the ABCB1 gene is associated with clinical outcomes in patients with gastric cancer.
20843132 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20839930 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20834157 DNA microarray and RT-PCR suggested that the expression of ABCB1 is significantly elevated in TP-110 resistant cells.
20833683 Observational study of gene-disease association. (HuGE Navigator)
20831524 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20826260 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20815915 High expression of P-gp was detected in vessel walls and the tissue surrounding the vessels, However, expression of P-gp was low in brain tumor cells.
20814731 3beta-acetyl tormentic acid induces apoptosis of resistant leukemia cells independently of P-gp/ABCB1 activity or expression.
20801498 CYP2C19 and ABCB1 genotypes are known to influence the effects of clopidogrel
20801498 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20801494 acute coronary syndromes with percutaneous intervention, when both ABCB1 and CYP2C19 are taken into account, there is an increased risk of major adverse cardiovascular events while on standard doses of clopidogrel.
20801494 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20720558 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20716514 Observational study of genetic testing. (HuGE Navigator)
20716130 Data suggest that levels of nitric oxide and Pgp critically modulate the recognition of tumour cells by dendritic cells.
20712525 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20707787 ABCB1 genotypes may be a clinical predictor of responsiveness for ondansetron for postoperative nausea and vomiting
20707787 Observational study of gene-disease association. (HuGE Navigator)
20702488 TXL upregulated the protein level of p21 and downregulated the protein levels of MMP-1 and MDR-1
20701289 Establishing an intestinal Caco-2 cell culture model with specific knock-downs of P-gp and BCRP and double knock-down of both proteins, we aimed to elucidate the impact of each transporter on transport of imatinib.
20699370 Data indicate that CDX2 directly regulates MDR1 gene expression through binding to elements in the promoter region.
20696882 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20689757 High MDR1 and ERCC1 gene expressions are associated with inferior outcome after cisplatin-based adjuvant chemotherapy for locally advanced bladder cancer.
20686816 Synergistic differentiation-inducing activity of Nutlin-1 combined with ATRA could be attributed to Nutlin-1 competitive binding to p-gp, leading to ATRA efflux inhibition, and then the differentiation pathways involved were therefore further activated.
20679960 Observational study of gene-disease association. (HuGE Navigator)
20679500 MDR1-expressing LLC-PK1 cells indicate that tolvaptan is a substrate of P-glycoprotein and inhibited basolateral to apical digoxin secretion.
20664232 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20662624 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20660695 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20658364 Over-expression of MDR1 may be associated with imatinib resistance in gastrointestinal stromal tumors.
20658178 The observation of study is the coexpression of MDR1 markers in primary and metastatic epithelial ovarian cancer cells.
20638924 Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFR C677T, (C) 0.59 and (T) 0.41; p53 Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T, (C) 0.52 and (T) 0.48.
20638924 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20636108 A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pylori-positive and Helicobacter pylori-negative subjects.
20634891 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627697 Polymorphisms of ABCB1 were not associated with differences in morphine use in the first 24h after surgery
20627697 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627363 MDR1 3435 CC genotype is an important prognostic factors associated with lower risk of progression of non-small-cell lung cancer patients
20627363 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20625815 study concldes there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer
20625815 Meta-analysis of gene-disease association. (HuGE Navigator)
20625352 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20624637 Expression of MDR1 mRNA was increased while the sensitivity to paclitaxel was decreased in A2780 cells management with the mimics of miR-27a.
20623213 data suggest MDR1 (GT1292-3TG) variation of P-gp may reduce drug resistance and that subjects with this genotype undergoing chemotherapy with drugs that are transported by P-gp could be more responsive to therapy than those with MDR1 wild-type genotype
20615085 Studies indicate that ABCB1 has been investigated extensively for the presence of sustained point mutations (SNPs), with at least 63 distinct allele changes already identified.
20605481 We failed to show an association between the ABCB1 C3435T polymorphism and the risk of anticonvulsant drug-resistance--{REVIEW}
20605481 Meta-analysis of gene-disease association. (HuGE Navigator)
20604570 CYP3A4, P-gp and BCRP proteins were quantified by Western blotting and/or enzyme activities in small intestine samples from 19 donors, and mathematical trends of these expressions with intestinal localization were established.
20602615 Observational study of gene-disease association. (HuGE Navigator)
20602612 Observational study of gene-disease association. (HuGE Navigator)
20589615 the expression levels of ABCB1 in PBMCs is influenced by gender
20587910 genetic polymorphism is associated with gastric cancer in an ethnic Iranian population
20587910 Observational study of gene-disease association. (HuGE Navigator)
20578904 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20571034 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20567810 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20563569 Our findings suggest that ABCB1 G2677T and C3435T may be useful determinants of risperidone plasma concentrations
20563569 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20558393 The results of this study suggested that the ABCB1 gene and exposure to organochlorine insecticides interact to increase parkinson disease risk.
20558393 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20556576 Troglitazone elevated PPARgamma activity and decreased P-gp expression in SGC7901/VCR cells, reversing the P-gp-mediated drug resistance.
20555295 Certain ABCB1 polymorphisms predict response to substrate medications in geriatric patients.
20554493 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20540746 study demonstrates, for the first time, that GCS upregulates MDR1 expression modulating drug resistance of cancer. GSLs, in particular globo series GSLs mediate gene expression of MDR1 through cSrc and beta-catenin signaling pathway
20533270 Positive correlation was detected between the expression of GCS and MDR1 mRNA in K562/A02 cells and MDR1 mRNA expression was down regulated after silencing the GCS gene expression.
20533057 association between T(1236) allele and T(1236)-G(2677)-C(3435) haplotype and less advanced colorectal cancer
20533057 Observational study of gene-disease association. (HuGE Navigator)
20532504 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20531015 Observational study of gene-disease association. (HuGE Navigator)
20528170 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20526235 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20525557 JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.
20512145 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20510202 MDR1-myosin regulatory light chain (RLC) interactions were characterized and it was determined that binding occurs via the amino terminal of the RLC, a domain that typically binds myosin heavy chain.
20510079 The expression of alpha-tubulin and MDR1 may play an important role in the development and progression of human non-small cell lung carcinoma.
20505666 Observational study of gene-disease association. (HuGE Navigator)
20504240 The MDR1 G2677T/A variation and UGT1A1*28 are independent risk factors for severe atazanavir-associated hyperbilirubinemia in Korean human immunodeficiency virus-infected patients.
20504240 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20501388 Low-dose fractioned irradiation can lower MDR1 and HIF1alpha expressions in esophageal cancer cells.
20496145 These data suggest that the ABCB1 c.1236C-c.2677G-c.3435C and c.1236T-c.2677T-c.3435T haplotypes have no clinically meaningful effect on the pharmacokinetics of aliskiren.
20496145 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20496015 MDR1 gene polymorphism could be a factor predisposing to B-chronic lymphocytic leukemia
20496015 Observational study of gene-disease association. (HuGE Navigator)
20492723 Tumor Treatment Fields (electric fields) alone and in combination with chemotherapeutic agents effectively reduce the viability of multidrug resistant cell sub-lines that over-express ABC transporters.
20491876 Meta-analysis of gene-disease association. (HuGE Navigator)
20490798 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20488228 Rifampicin and phenobarbital do not induce P-gp activity or P-gp expression in lymphocytes.
20479155 Observational study of gene-disease association. (HuGE Navigator)
20468060 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20464493 The C3435T polymorphism of MDR1 influences H. pylori-related inflammatory conditions in the stomach, especially in older subjects.
20464493 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
20448249 MDR1 polymorphisms investigated in this study are not associated with antiepileptic drug resistance, but the compound genotype CC3435/GG2677 might have an effect on antiepileptic drug response.
20448249 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20440618 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20438811 Polymorphisms of the ABCB1 exon 12 C1236T, exon 21 G2677A/T (Ala893Ser/Thr) & exon 26 C3435T were correlated with levosulpiride level. The PK paramters of ABCB1 2677TT & 3435TT subjects were higher than in subjects with a wild-type allele.
20437864 The study showed that MDR1 and BCRP may be the most important factors for drug resistance in hepatocellular carcinoma
20430184 Little evidence of a correlation of P-gp gene expression between peripheral blood and liver.
20417680 Finding disproves a general association between ABCB1 polymorphisms and drug response in epilepsy patients.
20417680 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20416158 Docetaxel had no effect on expression of P-gp in HL-60/ADR cells.
20415563 Observational study of gene-disease association. (HuGE Navigator)
20411349 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20403997 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20403441 P-glycoprotein expression in temporal lobe may be associated with seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy
20394729 These results suggest that P-gp in the membrane is in the closed conformation that has a high affinity for drug substrates.
20389299 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20388796 although AEG-1 does not affect MDR1 gene transcription, it facilitates association of MDR1 mRNA to polysomes, resulting in increased translation
20383212 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20376628 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20372866 Survivin transcription was associated with P-glycoprotein/MDR1 overexpression, PI3k/Akt pathway was involved in P-glycoprotein/MDR1 associated survivin transcription activity in the multidrug resistant MCF-7 breast cancer cells.
20371868 Observational study of genetic testing. (HuGE Navigator)
20371218 Observational study of gene-disease association. (HuGE Navigator)
20369487 The expression of COX-2 was correlated with the expression of P-gp and Topo II alpha significantly in gastrointestinal carcinomas.
20368717 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20368715 Observational study of gene-disease association. (HuGE Navigator)
20357698 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20354687 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20338046 We investigated methylation patterns in the promoter regions of ABCB1, ATM, BRCA1, CDH3, CDKN2A, CXCR4, ESR1, FBXW7, FOXC1, GSTP1, IGF2, HMLH1, PPP2R2B, and PTEN75 in well-described pre-treatment samples from locally advanced breast cancer
20332423 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20331623 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20304939 the synergistic effect of ABCB1 and abcg2 on brain/plasma and testis/plasma ratio of drugs can be explained by their contribution to the net efflux at the blood brain barrier and blood testis barrier without any interaction between them
20297661 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20234362 contributors to the inherent aggressive and resistant nature of malignant melanoma.
20233511 Higher positive expression of P-glycoprotein is associated with multidrug resistance in gastric cancer.
20217131 Expression of HIF-1alpha and MDR1/P-gp in colon carcinoma and HIF-1alpha expression may be associated with the gene MDR1 (P-gp) and interactively
20212519 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20209493 Findings substantiate the notion that modulation of the temporal and spatial distribution of P-gp in cancer cells may be a valid therapeutic strategy to alleviate the MDR phenotype, and signal to Rab4 as a potential target.
20204543 MDR1 polymorphisms correlate with imatinib response in chronic myeloid leukemia.
20204543 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20195292 MDR1 genetic variants were significantly associated with the greater increase in fasting glucose level in blood when patients were using olanzapine for schizophrenia.
20195292 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20193114 Expression of p-glycoprotein was significantly lower in esophageal squamous cell carcinoma than in normal mucosa.
20189873 The MDR1G2677 T/A genotype influenced drug resistance and caused gastrointestinal toxicity in advanced NSCLC patients.
20189873 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20182906 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20179710 Variant alleles in the ABCB1, SLC22A16 and CYP2B6 genes are associated with response to AC therapy in the treatment of breast cancer.
20179710 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20177420 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20173083 Observational study of genotype prevalence. (HuGE Navigator)
20166790 Data show that Gene variants in MDR1 may influence guanfacine response on hyperactive-impulsive behaviors via altered membrane transport.
20166790 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20160155 MDR1 variants influenced the extent of CYP3A inhibition by grapefruit juice in Chinese healthy subjects
20160155 Observational study of gene-disease association. (HuGE Navigator)
20147896 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20146171 raised blood MDR-1 gene expression levels in patients with Graves-Basedow disease may be associated with the activity of the disease and the resistance to its treatment.
20136364 Observational study of genetic testing. (HuGE Navigator)
20127181 Results suggest that C3435T MDR1 polymorphism is associated with colorectal cancer, and that allele C may be important in decreased susceptibility to colorectal cancer.
20125118 This study provides strong evidence that changes in ABCB1 promoter methylation, ABCB1 promoter usage and ABCB1 transcript expression can be temporally and causally correlated with the acquisition of drug resistance in breast tumor cells.
20110084 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20110013 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20103600 Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation
20102361 Observational study of gene-disease association. (HuGE Navigator)
20085590 Bmi-1 gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression.
20082268 There was a significant association between MDR1 expression levels and C3435T polymorphism in the patients. C3435T polymorphism may play a role in inducing drug resistance by altering the expression level of the MDR1 gene.
20082268 Observational study of gene-disease association. (HuGE Navigator)
20078610 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20064729 This study suggest that stratification by patient age and by the aetiology of epilepsy could contribute to unmask the association between ABCB1 polymorphisms and drug-resistance of epilepsy.
20064729 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20061922 Association of ABCB1 haplotypes with cyclosporine dosage has no effecton on acute rejection or on the development of renal impairment after heart transplantation.
20061922 Observational study of gene-disease association. (HuGE Navigator)
20060871 The present study does not suggest a major influence of MDR1 G2677T/A and C3435T polymorphisms on treatment response during short-term risperidone therapy in patients with schizophrenia or schizoaffective disorder.
20060871 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20056007 Quantitative methylation analysis identified ABCB1, FOXC1, PPP2R2B and PTEN as novel genes to be methylated in ductal carcinoma in situ.
20040338 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20038391 Genotype differences in MDR1 3435C > T can explain part of the variability in cyclosporine absorption among individuals in the population of Spanish cardiac transplant recipients.
20038391 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20037778 The inhibition of MDR1 expression by UHRF1 may provide potential ways to overcome multidrug resistance (MDR) in breast cancer treatment.
20031551 Observational study of gene-disease association. (HuGE Navigator)
20030680 Polymorphisms in ABCB1 gene are associated with calcineurin inhibitors-related neurotoxicity
20030680 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20025534 this study may contribute to population-specific haplotype data on the MDR1 gene
20025534 Observational study of genotype prevalence. (HuGE Navigator)
20017669 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20012601 Lovastatin increased the absorption of verapamil by inhibiting P-gp and inhibited the first-pass metabolism of verapamil by inhibiting CYP3A4 in the intestine and/or liver in humans.
20004641 P-glycoprotein ATPase activity was compared in inside-out plasma membrane vesicles and living NIH-MDR1-G185 cells with the aim to detect substrate transport.
19997080 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19969351 Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells.
19958644 P-glycoprotein can transfer from drug resistant hepatocellular cells to sensitive hepatocellular carcinoma cells.
19956892 the ABCB1 polymorphism at 3435 is associated with clinical outcomes after paclitaxel-based combined chemotherapy in advanced gastric cancer patients
19956892 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19956884 MDR1, MRP2, MRP3 and MRP5 levels are decreased by tetramethylpyrazine in human hepatocellular carcinoma cells
19956635 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19954620 The expression and function of P-gp in leukemia cells are inhibited by intracellular acidification.
19950199 P-gp expression in tumor spheroids is closely related to the glycolytic metabolism of tumor cells and can be downregulated by glycolysis inhibitors via mechanisms that involve changes in the cellular redox state.
19946748 no statistically significant association was found between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls
19946748 Observational study of gene-disease association. (HuGE Navigator)
19940361 Studies show that COX-2 inhibitors prevent chemoresistance development in breast cancer cells by inhibiting P-gp expression and function by a mechanism that involves PGH2 generation and NF-kappaB activation
19934793 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19934400 Observational study of gene-disease association. (HuGE Navigator)
19930591 Our results suggest that MDR1 polymorphisms affect the relationship between meat and colorectal cancer risk
19930591 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19925383 MDR1 haplotypes and CYP3A5*3 genotypes can be related to trough level (C(2)) and peak level (C(0)) of CsA, respectively.
19925383 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19924384 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19916993 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19904007 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19896927 These findings indicate that the C3435T and G2677T/A SNPs in MDR1 are significantly associated with decreased placental P-glycoprotein expression, while the C1236T and C3245T homozygous variants are associated with an increase in its efflux activity.
19896927 Observational study of gene-disease association. (HuGE Navigator)
19891551 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19890215 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19888426 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19885596 polymorphisms in TYMS, MTHFR, p53 and MDR1 may have roles in breast cancer
19885596 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19885591 down-regulation of MDR genes MDR1, MRP2, and LRP is responsible for the improvement in the chemotherapeutic sensitivity of hSSTR2-expressing pancreatic cancer cells
19879256 Hypomethylation of MDR1 promoter in invasive ductal carcinomas of breast accounted for P-gp overexpression and aggressive biologic behavior in a subset of patients.
19878569 Observational study of gene-disease association. (HuGE Navigator)
19865079 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19862647 MDR1 polymorphism is associated with patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
19862647 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19858398 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19855314 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19845769 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19844206 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19842932 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19840843 The species specificity of human and rat in terms of susceptibility to drugs at the level of the placental barrier using in vitro models in order to improve translation from rat to human is reported.
19840446 Expression of P21 was enhanced along with increasing concentration of tetrandrine in K562 cells.
19832037 Report enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma.
19819701 Comparison of the ABCB1 crystal structures with structures of bacterial homologs suggests a critical role for an axial rotation of transmembrane helices for high-affinity binding and low-affinity release of ligands during transmembrane transport.[Review]
19819348 Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative population are reported.
19819348 Observational study of gene-disease association. (HuGE Navigator)
19815951 The risk of infertility is significantly elevated by two-fold in individuals carrying at least one thymine nucleoide allele (CT and TT genotypes) of the ABCB1 gene.
19815951 Observational study of gene-disease association. (HuGE Navigator)
19812066 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19802823 the CYP3A4*1B G allele is associated with a lower risk of elevated statin plasma levels, particularly in women and in users with the ABCB1 3435T variant allele.
19796545 The 3435T polymorphism in the ABCB1 gene is allied with colchicine unresponsiveness in familial Mediterranean fever and was linked to PGP(p-glycoprotein ) activity
19796545 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19794400 Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19785662 Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and implications for altered anti-cancer effects and pharmacological properties are reported.
19784880 The C3435T polymorphism of the MDR-1 gene influences ADP dependent platelet reactivity in patients with acute coronary syndrome but does not affect mid-term prognosis in this population.
19774638 MDR1 2677GG and 3435CC genotypes predicted a poor prognosis for patients in a Taiwanese population that received the TPOG-ALL-93-SR treatment protocol
19774638 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19771428 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19762492 Observational study of gene-disease association. (HuGE Navigator)
19761365 Observational study of genotype prevalence. (HuGE Navigator)
19760622 mothers who carry the ABCB1 3435C > T polymorphism are at significantly increased risk for having offspring with cleft lip/palate, especially mothers using medication in the periconceptional period.
19752884 MDR1 C3435T polymorphism could have a function in the risk of developing breast cancer risk and interindividual variability in therapeutic outcome after anthracycline-based chemotherapy of the same breat cancer patients.
19752884 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19748977 P-glycoprotein expression had no effect on the accumulation of [(14)C]efavirenz and [(3)H]nevirapine.
19745014 Observational study of gene-disease association. (HuGE Navigator)
19740399 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19740397 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19737648 Data suggest that the translocation, preceding amplification by several selection steps, activated ABCB1 gene expression.
19732422 ABCB1, ABCC4 and ABCC5 models display distinct differences in the electrostatic properties of their drug recognition sites.
19729888 MDR1 C3435T polymorphism represents a promising new factor to indicate the different outcome in relapsed/refractory multiple myeloma patients. T allele carriers would be expected to show a better response to chemotherapy
19729888 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19729569 3435C>T polymorphism influenced tacrolimus concentrations and dosage requirements in the first days after liver transplantation
19729569 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19723047 Data suggest that the flavone may be used to reduce the excretion of the anticancer agents via P-glycoprotein and increase the pharmacological action of it in cancer cells.
19720156 integrated component of the blood-testis barrier
19714749 High gene expression of ABCB1 is associated with medical treatment response and long-term remission in patients with ulcerative colitis
19694740 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19693666 GCSshRNA could efficiently suppress GCS and MDR1 expression in vitro and in vivo and these findings may be used as one of the methods to reverse multidrug resistance in breast cancer
19692168 Observational study of gene-disease association. (HuGE Navigator)
19688973 Observational study of genetic testing. (HuGE Navigator)
19685447 these results suggest the possibility of a heterozygous advantage for certain MDR1 variants for ulcerative colitis.
19685447 Observational study of gene-disease association. (HuGE Navigator)
19672706 Women homozygous for the major ABCB1_rs2214102_G allele were found to be at a significantly increased breast cancer risk associated with combined estrogen-progestagen therapy.
19672706 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19667110 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19663741 This paper reviews ABCB1 implication in the pathophysiology of Parkinson's disease and its role in the cerebral distribution of --REVIEW
19663671 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19661039 Significantly higher prevalence of 3435TT genotype in exon 26 of MDR1 gene in patients with breast cancer might suggest the possibility of increased breast cancer susceptibility. Genotypes did not show significant association to response to chemotherapy.
19661039 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19659438 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19655414 Results demonstrated the augmented adjuvant anti-tumor effects of AC-CF not only through down regulation of MDR-1 expression but also through a COX-2 dependent apoptosis pathway, involving down-regulation of COX-2 and p-AKT and up-regulation of PARP-1.
19651439 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19644155 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19639185 short-term treatments by thalidomide do not induce any significant change on ABCB1 gene expression in drug-resistant 8226 human myeloma cells.
19636001 Observational study of genotype prevalence, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19632288 The inhibitory effect of Mangifera indica stem bark and related polyphenols on ABCB1 in human cell lines is reported.
19631272 The MDR1-expressing oocyte system offers researchers with an alternative in vitro method to screen compounds and may allow one to probe P-gp drug-drug and/or drug-inhibitor interactions.
19629677 This in vitro study indicates that expression levels and activity of BCRP, and P-gp at the blood-brain barrier may be altered by acute inflammation, possibly affecting the penetration of their substrates into the brain.
19626470 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19625176 Observational study of gene-disease association. (HuGE Navigator)
19625010 ABCB1 polymorphisms may alter Delta9THC distribution, its psychoactive effects and individual vulnerability to dependence.
19625010 Observational study of gene-disease association. (HuGE Navigator)
19622290 High expression of MDR1, MRP1, ABCG2 proteins in gastric cancer is related with the resistance to epirubicin.
19621425 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19619277 P-gp and BCRP are inhibited by a novel chalcone derivative, JAI-51
19617466 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19617332 The expression of MDR1 glycoprotein (or its equivalents in mice) affects the retention of (64)Cu-ATSM and -PTSM in the human and murine tumors tested.
19615260 P-gp and LRP expressions but not MRP expression are important in the mechanism of drug resistance associated with a poor clinical outcome in previously untreated non-Hodgkin's lymphoma.
19605531 Single Nucleotide Polymorphisms in ABC-transporter genes may serve as pharmacogenetic markers associated with clinical response to Mitoxantrone therapy in multiple sclerosis.
19605531 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19593168 Study shows a significant in vivo role of CYP2C19 and the P-gp transporter in the pharmacokinetics of clozapine.
19593168 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19584153 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19575027 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19571437 The results confirm earlier observations on absence of association of ABCB1 polymorphisms with medically refractory epilepsy.
19564743 presence of P-gp is an independent prognostic factor in children with acute lymphoblastic leukemia
19558216 Data show that 12 SNPs from CETP, APOAI, ABCB1, CYP7A1, and HMGCR genes to be associated with baseline LDL-C and high-density lipoprotein cholesterol levels and increased risk of CAD.
19558216 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19555315 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19552816 Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
19550405 it is possible to elevate the efficiency of polychemotherapy by its individualization based on the expression patterns of P-gp, GST and MT on tumor cells of the patients with the triple-receptor-negative breast cancer
19549365 Intracellular acidification can inhibit the expression and function of P-gp in K562/A02 cells.
19546880 Observational study of genotype prevalence. (HuGE Navigator)
19539100 ABCB1 polymorphisms may be an important contributor to observed variability in plasma cloxacillin concentrations
19539100 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19523815 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19513507 The overexpression of ABCB1 and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells.
19506903 Methylated state of this set of genes may be more specific to the late rather than the early stage of NSCLC.
19504558 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19490125 Results suggest that the linker region regulates the inherent substrate specificity of P-glycoprotein.
19483282 Hypomethylation of the promoter region of mdr-1 gene may be an important epigenetic factor for the development of multidrug resistance in MCF-7/Adr cells.
19474786 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19470925 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19470683 Renal transplant recipients with T allelic variants in ABCB1 exons 21 or 26 are at increased risk for cyclosporine A-related adverse events.
19470683 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19460946 Suggest a role for the vitamin D receptor in the intestinal induction of human ABCB1.
19456124 Results indicate that transmembrane helix 12 plays a key role in the progression of the ATP hydrolytic cycle in ABCB1, even in the absence of the transported substrate.
19450124 In Chinese epilepsy patients, the ABCB1 intronic polymorphism and the coding polymorphism and haplotypes containing them, may be associated with drug resistance.
19450121 Polymorphism of this gene may be involved in multidrug resistance in epilepsy.
19447222 Variations in the expression of the efflux transporter MDR1ariations in the expression of the efflux transporter MDR1 affect the intracellular accumulation of melphalan and thus determine its cytotoxicity in cancer.
19445670 antiapoptotic proteins play a significant role in the chemoresistance of chondrosarcoma cells independent of P-glycoprotein
19440975 Findings suggest that ABCB1 3435C>T genotype can influence serum levels of cortisol and aldosterone during the postmenstrual phase of the normal menstrual cycle.
19437139 ABCB1 variants among 278 healthy Brazilian individuals were analyzed and the genotypic and allelic frequencies were determined.
19433561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19421142 RNA samples from 21 neuroblastoma showed a highly significant FZD1 and/or MDR1 overexpression after treatment, underlining a role for FZD1-mediated Wnt/beta-catenin pathway in clinical chemoresistance.
19415824 A higher risk of antiepileptic drug failure in ABCC2 -24T allele carriers possibly because of compensatory upregulation of ABCB1.
19415824 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19415305 Report ABCB1 gene polymorphisms and haplotype analysis in colorectal cancer.
19415305 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19405050 Allelic frequencies for the ATP-binding cassette sub-family B polymorphisms were 52% (3435C) and 54% (1236C) and the most common haplotype (1236C-3435C) occurred with a frequency of 45.5%.
19405050 Observational study of genotype prevalence. (HuGE Navigator)
19400747 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19399413 Silencing MDR1 can effectively reverse the paclitaxel resistance in ovarian cancer cells.
19393132 21 % of renal cell carcinoma samples revealed positive results for MDR1.
19388849 C3435T MDR1 polymorphism was not associated with the susceptibility to breast cancer.
19388849 Observational study of gene-disease association. (HuGE Navigator)
19384922 Neural Stem/Progenitor Cells Show Decreased ABCB1 Expression During Differentiation and Development
19384845 Tubular cells exposed to albumin present a decrease in both protein and gene expression of Pgp with impairment in transport function.
19384171 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19376366 FK506 and cyclosporine blood levels in kidney transplant recepients are dependent on cyp3a5 and MDR1 genes.
19376366 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19373654 Results suggest that genotyping rs1045642 may be a useful predictor of outcome in PCM and could indicate modified treatment modalities in certain individuals.
19373654 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19370547 Buprenorphine most likely is not a P-gp substrate and concerns regarding ABCB1 mediated drug-drug interaction are not expected
19360342 Fluorodeoxyglucose (FDG) uptake in hepatocellular carcinoma is weakly correlated with GLUT-1 expression; FDG could be a substrate of P-gp, which may act as an efflux pump to reduce FDG accumulation.
19356075 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19352661 Data show that changes in the expression of MDR1 gene after short-term incubation of lymphoblasts with prednisolone may have prognostic value in pediatric de novo ALL patients.
19351508 Data show that sorafenib can inhibit the expression of the mdr1 gene product P-gp, so as to reverse the multidrug resistance of HCC cells.
19349543 ABCB1 (C3435T)T/T (membrane transport) was associated with irinotecan plus cisplatin -related diarrhea
19349540 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19343046 Observational study of gene-disease association. (HuGE Navigator)
19332043 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19331170 The promoter methylation of MDR1 seems to have a significant role in carcinogenesis and tumor progression in the stomach.
19317599 The researchers investigated the possible association between the MDR1 C3435T polymorphism and the risk of developing childhood acute lymphoblastic leukemia and found no significant association.
19317599 Observational study of gene-disease association. (HuGE Navigator)
19304516 The expression of P27(Kip1) in valproic acid-treated HL-60/HT cells was significantly lower but P170 expression significantly higher than that of HL-60 cells and normal mononuclear cells.
19290795 CYP3A5 and ABCB1 gene polymorphisms are associated with blood pressure and hypertension in humans and rats [REVIVEW].
19289993 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19288456 Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
19288029 Both frequency and level of MDR1 methylation were higher in UC onset at younger or in middle age with the same genotype
19288029 Observational study of gene-disease association. (HuGE Navigator)
19285158 This review summarizes recent findings on the 3435C>T polymorphism of MDR1 and the haplotype to which it belongs[review]
19285054 ABCB1 polymorphisms contribute to the genetic variability of plasma values of lipids and lipoproteins in healthy people.
19285054 Observational study of gene-disease association. (HuGE Navigator)
19282874 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19282465 A common polymorphism in the efflux transporter P-glycoprotein is associated with reduced bone mass and might confer susceptibility to glucocorticoid induced osteoporosis.
19282465 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19282152 MDR-1 halplotypes may ply a role in the tardive dyskinesia.
19282152 Observational study of gene-disease association. (HuGE Navigator)
19279227 hIRIP expression can regulate cargo assembly and function of efflux transporters, including P-glycoprotein, which mediates one of the most common mechanisms of the multidrug resistance
19267185 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19258929 Clinical trial of gene-disease association. (HuGE Navigator)
19255821 examined ten coding single nucleotide polymorphisms in the multidrug resistance gene 1 (MDR1) encoding P-glycoprotein and found no significant association between coding MDR1 gene polymorphisms and Parkinson's disease
19255821 Observational study of gene-disease association. (HuGE Navigator)
19250544 MDR1 polymorphism does not seem to play an important role in colorectal carcinogenesis in Norway population
19250544 Observational study of gene-disease association. (HuGE Navigator)
19243013 Report expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.
19239339 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19239322 Observational study of genotype prevalence. (HuGE Navigator)
19238649 ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin
19238649 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19238367 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19238328 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19236881 only three of the P-gp transmembrane segments are independently stable in the ER membrane, while the majority depend on the presence of neighboring loops and/or transmembrane segments for efficient insertion
19232333 The 6bp-deletion affects the PAR-2(SV1) expression greatly, contributing to the adjustment of expression and function of total PXR--which leads to the changed target gene expressions, partly explaining interindividual variations in CYP3A4 and MDR1.
19228751 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19228205 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19224656 Report locally increased P-glycoprotein function in the brains of patients with major depression.
19215299 the protein possesses intrinsic structural flexibility to allow cross-links to occur between helices 6 and 12 of P-glycoprotein, thereby reconciling crystallographic models with available experimental data from cross-linking.
19207033 ABCB1 single nucleotide polymorphisms are not predictors of lopinavir and ritonavir concentrations in blood plasma, semen or saliva of HIV-infected men under stable HAART treatment.
19207033 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19205682 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19203783 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19197249 Observational study of gene-disease association. (HuGE Navigator)
19196542 The results of this study suggested an involvement of ABCB1 variants in Swedish parkin sondiease patients.
19196542 Observational study of gene-disease association. (HuGE Navigator)
19192650 ABCB1 polymorphisms are not associated with colon cancer risk and prognosis in a selected patient population.
19192650 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19188929 Identification of MDR1 and BCRP as genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.
19185004 Mutation I541F causes mislocalization of both ABCB4 and ABCB1.
19184162 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19183974 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19178561 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19167193 This study suggests that genetic polymorphisms in ABCB1 transporters may not be significant predictors of drug response in epilepsy patients.
19167193 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19165709 ABCB1 immunostaining was observed in microvessel endothelial cells as early as 22 (0/7) weeks, increasing in prevalence and intensity with maturation in infants born at 22 (0/7)-42 (0/7) weeks of gestation
19159494 The models interpret the effects of several mutants in the nucleotide-binding domains (NBDs), within the transmembrane domains (TMDs) or at the NBD:TMD interface. The docking results suggest that the protein has multiple binding sites.
19151448 Breast cancer patients with positive Her-2 expression do not always respond to Anthracycline, it means that only patients with T/T genotype at position 3435 located in exon 26 of MDR1 gene have clinical response.
19151448 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19143748 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19141860 Observational study of gene-disease association. (HuGE Navigator)
19138818 Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity.
19137355 MDR-1 in rheumatoid arthritis seems to have a role in disease activity rather than the refractoriness to methotrexate therapy
19129072 ABCB1 gene induction decreases disease-free and overall survival in patients with locally advanced breast cancer
19115152 In this study, the G2677T/A polymorphism observed in the MDR1 gene was not found to be a risk factor for Crohn's disease or ulcerative colitis.
19115152 Observational study of gene-disease association. (HuGE Navigator)
19114346 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19107781 MDR1 gene may be associated with clinical phenotypes of Crohn disease in children
19107781 Observational study of gene-disease association. (HuGE Navigator)
19107762 The current study demonstrated that common polymorphisms in the 3' untranslated region of ABCB1 and ABCC1 may contribute to the etiology of lung cancer.
19107762 Observational study of gene-disease association. (HuGE Navigator)
19106083 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19101657 These results suggest that higher P-glycoprotein activity on CD3(+) or CD4(+) cells necessitated treatment with higher steroid doses in order to achieve a clinical response in myasthenia gravis patients.
19100412 Less P-GP is found after cyclosporine treatment than after tacrolimus treatment in kidney after kidney transplantation.
19099191 Data provide new insights into the mode by which multidrug-resistant breast cancers evade cytotoxic attacks from P-glycoprotein substrates and also suggest a role for P-gp/cellular prion protein (PrP(c)) interaction in this process.
19093297 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19086053 Observational study of gene-disease association. (HuGE Navigator)
19074885 Observational study of gene-disease association. (HuGE Navigator)
19074750 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19072639 A correlation between MDR1 genetic polymorphisms C3435T and G2677T/A, as well as haplotypes derived from C1236T, G2677T/A and C3435T, with methylation status of MDR1 promoter region was found in this study.
19072639 Observational study of gene-disease association. (HuGE Navigator)
19072027 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19067682 ABCB1 polymorphisms were not related with transplantation outcome.
19067682 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19052456 Expression of both efflux transporters BCRP and MDR1 is reduced, but only in inflamed tissue of patients with active UC.
19048498 silent MDR1 C1236T (Gly412Gly) polymorphism in a Turkish population
19048498 Observational study of genotype prevalence. (HuGE Navigator)
19048359 Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein.
19037199 High levels of P-gp activity observed in the lymphocytes of children up to 6 months of age may affect the efficacy of intracellular drugs.
19035180 Tetrandrine inhibits the expression of mdr1 mRNA in K562 cells.
19034006 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19033450 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19020725 MDR1 siRNAs specifically reverse the multidrug resistance of colon cancer cells
19019175 Although expression of O6-methylguanine-DNA methyltransferase is a significant prognostic factor in diagnosis and prediction of chemotherapy effects in glioblastoma, neither Mrp-1 nor P-glycoprotein expression is a prognostically significant factor.
19010156 Liver transplantation from single nucleotide polymorphism donors of MDR1 had a lower frequency of renal dysfunction, the same rejection rate, and a higher rate of diabetes than the other groups.
19010156 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19006072 Cytologic evaluation of GST-pi and P-gp expression may predictor the response to treatment and the survival of patients with advanced NSCLC.
19005482 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19005421 common SNPs in the MDR1 gene are associated with an overall susceptibility for ulcerative colitis and specific disease phenotypes in North Indians
19005421 Observational study of gene-disease association. (HuGE Navigator)
19005401 ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms.
19005401 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19001875 These findings suggest that the increased expression of ABCB1 upon acquisition of docetaxel resistance in breast tumor cells can be multifactorial, involving both epigenetic changes in promoter usage and regional chromosome amplification.
18996102 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18989234 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18981011 Observational study of gene-disease association. (HuGE Navigator)
18981009 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18979093 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18978522 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18972317 Our study reports expression of MRP and LRP in nasal NK/T-cell lymphoma
18940259 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18936931 no evidence was found that there was a relationship between the CYP3A5*3, MDR1 C1236T and MDR1 C3435T polymorphisms and CsA dose-adjusted trough concentrations
18936931 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18936436 Observational study of genotype prevalence. (HuGE Navigator)
18930278 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18926661 The frequency of C3435T, an important determinant for multidrug resistance, displays significant difference in ethnics. It may help for individualizing therapy for cancer, HIV and other common diseases.
18926661 Observational study of genotype prevalence. (HuGE Navigator)
18855017 High expression of MDR1 mRNA in blood vessels of the nervous system and in other tissues support the physiological role of MDR1 as a regulator of intracellular levels of endogenous and exogenous compounds.
18854777 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18851956 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18851949 These data indicate that the tumor multidrug resistance mediated by P-gp could be reversed by sustained intracellular acidification through down-regulating the P-gp expression and activity.
18838068 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18836089 Association of the ABCB1 gene polymorphisms with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients is reported
18836089 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18829547 Lapatinib reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.
18823430 MDR1 genotype did not affect the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin.
18823430 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18820766 Although ABCB1 polymorphisms are not associated with SLE, the evaluation of ABCB1 polymorphisms, especially the 2677A allele, in other immunological processes may be relevant since our data suggest that they can affect clinical features of this disease.
18819034 Observational study of gene-disease association. (HuGE Navigator)
18816302 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18812689 The 2677 GG genotype was associated with a significantly better response to chemotherapy compared with the combined 2677 GT and TT genotype (p = 0.035).
18812689 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18812236 ABCB1 polymorphisms are not associated with drug resistance in north Indian epileptic patients
18812236 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18810246 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18809583 APE1 downregulation sensitizes MDR1-overexpressing tumor cells to cisplatin or doxorubicin, showing APE1's critical role in YB-1-mediated gene expression and drug resistance in tumor cells.
18804983 Observational study of gene-disease association. (HuGE Navigator)
18801030 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18765553 Women who carried the minor T/A alleles at the 2677G>T/A polymorphism were significantly less likely to relapse following treatment compared with homozygote GG carriers
18765553 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18760199 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18756548 Immunohistochemical expression and clinical significance of P-gp in previously untreated NK/T-cell lymphoma, nasal type, are reported.
18718676 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18718061 Angelicasinensis (Oliv) diels compound injection can partly reverse the multidrug resistance of K562/A02 cells by down-regulating Mdr1.
18717915 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18713069 MDR1-deficient cells exhibited UCB uptake and cytotoxicity comparable with controls.
18708991 In patients with schizophrenia the CYP2D6 genotype has a significant effect on the steady-state plasma levels of risperidone, while ABCB1 polymorphisms have a moderate effect on those of 9-hydroxyrisperidone and the active moiety.
18708991 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18708637 disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator
18704002 in renal allograft recipients the CYP3A5*3/*1 genotype, but not polymorphisms of MDR1 or CYP3A4) is associated with a reduced susceptibility for the inhibitory effects of fluconazole on tacrolimus metabolism
18702631 significant association between gingival overgrowth and the 3435TT genotype was confirmed by logistic regression analysis
18696186 in patients with femoral head osteonecrosis, The synergistic index between the ABCB1 and CBP genes was >1.00 (1.99), revealing the presence of an interaction
18696186 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18695635 In a study of Japanese renal transplant recipients, there are no significant differences in the dose-adjusted area under the curve of mycophenolic acid glucuronide between the ABCB1 C3435T and ABCC2 C-24T genotypes.
18695635 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18689982 ubiquitination of P-gp and CD147 might be a novel method for tumor therapy
18688081 Observational study of genotype prevalence. (HuGE Navigator)
18687982 The genotype of the MDR1 exon12 C1236T SNP is a novel independent predictive factor for outcome of temozolomide treatment in glioblastoma patients.
18687982 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18680196 Results compare the relative amounts of ABCb1 (Pgp) and ABCc1 (Mrp1)at the blood-brain and blood-cerebrospinal fluid barriers, located respectively at the brain capillary endothelium and the choroid plexus epithelium.
18676680 Observational study of gene-disease association. (HuGE Navigator)
18673531 MDR1 mRNA levels in gastric cancer cells are significantly lower than those in colon cancer cells, which is at least in part due to different epigenetic regulations such as DNA methylation and/or histone deacetylation.
18657537 Structural insights into ABCB1 are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data.
18654608 REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer
18650266 Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif.
18644389 P-glycoprotein might not be involved in the carcinogenesis of H. pylori-related gastric cancer.
18644389 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18641553 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18639335 results do not support major influence of MDR1 variants on the risk of myeloma in Caucasians.
18639335 Observational study of gene-disease association. (HuGE Navigator)
18636247 Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients.
18636247 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18628469 negative implications for docetaxel treatment in androgen-independent prostate cancer patients carrying ABCB1 variant genotypes.
18628469 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18622260 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18619980 bioavailability enhancement and reducing toxicity of irinotecan by P-gp inhibition but in another way also reiterate the significance of elucidating herb-drug interactions
18619946 MicroRNAs miR-27a and miR-451 are involved in activating the expression of P-glycoprotein, the MDR1 gene product that
18607581 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18602086 vitamin D receptor induces MDR1 expression in a 1alpha,25-dihydroxyvitamin D(3)-dependent manner
18596043 Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
18593522 Data show that changes in P-glycoprotein are the result of many seizures; are caused by the anti-epileptic drugs, or truly reflect pharmacoresistance.
18589174 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18588889 These results indicate that Pgp down-regulates BCRP expression in a drug-free state in which JNK/c-Jun is involved.
18582803 Our data do not justify genotyping of the investigated single nucleotide polymorphisms (SNPs) to assess the development of renal dysfunction post-HTx.
18582803 Observational study of gene-disease association. (HuGE Navigator)
18581211 Report a novel nanocapsule delivery system to overcome intestinal degradation and drug transport limited absorption of P-glycoprotein substrate drugs.
18581209 Observations suggest a possible down regulation/inhibition of P-gp by COX inhibitors, which may enhance the accumulation of chemotherapy agents.
18574677 Disruption of lipid rafts by depletion of membrane cholesterol with methyl-beta-cyclodextrin abolishes Tat-mediated RhoA activation and P-glycoprotein (P-gp) upregulation
18570599 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18568776 Report correlation between expression of MDR1 and drug resistance in glioblastomas.
18559609 Dasatinib is a substrate of both efflux proteins, ABCB1 and ABCG2.
18550244 MDR1 variants G2677T and C3435T are not associated with therapeutic response to paroxetine in patients with major depression
18550244 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18547906 An ABCB1 polymorphism is associated with virological efficacy in HIV-infected patients treated with non-boosted protease inhibitor (PI)-containing regimens but not with those containing boosted PIs.
18547906 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18543120 Our results suggest that the MDR1 C3435T polymorphism may confer susceptibility to polydipsia in SCZ.
18543120 Observational study of gene-disease association. (HuGE Navigator)
18539442 Suggest that Pgp inhibition by cyclodextrin treatment arises through modulation of its membrane microenvironment, rather than as a result of concomitant cytotoxicity.
18524988 Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia.
18524988 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18518969 Observational study of gene-disease association. (HuGE Navigator)
18518855 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18511651 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18509327 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18509181 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18502461 Influence of ABCB1 polymorphism on prednisolone pharmacokinetics in renal transplant recipients was evaluated. Its allelic variants did not affect patient variability of plasma prednisolone concentration.
18502461 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18494787 Observational study of gene-disease association. (HuGE Navigator)
18474294 MDR1/ABCB1 gene plays in the initiation and progression of high-microsatellite instability colorectal cancer development.
18474294 Observational study of gene-disease association. (HuGE Navigator)
18460034 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18444945 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18442890 ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals.
18442890 Observational study of gene-disease association. (HuGE Navigator)
18441325 HA binding to tumor cells promotes Nanog protein association with CD44 followed by Nanog activation and the expression of pluripotent stem cell regulators, and forms a complex with Stat-3 in the nucleus leading to Stat-3 and MDR1 activation
18440836 P-glycoprotein has a role in renal clear cell carcinoma
18436433 This study findings failed to prove an association between C3435T polymorphism and drug resistance in a sample of Turkish patients with refractory epilepsy who underwent resective brain surgery.
18436433 Observational study of gene-disease association. (HuGE Navigator)
18424454 ABCB1 variants may have clinical relevance by influencing the methadone dose required to prevent withdrawal symptoms and relapse.
18424454 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18416940 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18414651 Observational study of gene-disease association. (HuGE Navigator)
18408564 CYP3A5*1 genotype as well as the MDR1 mRNA level in enterocytes contributes to interindividual variation in the CL/F of tacrolimus in adult recipients early after living-donor liver transplantation.
18408564 Observational study of gene-disease association. (HuGE Navigator)
18408562 Human ABCB1 polymorphisms may alter the interactions between Pgp and substrates, and provided functional evidence for ABCB1 haplotypes-associated epilepsy treatment responses.
18408562 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18408561 Genetic variability of MDR1 should be considered as an important factor that influences the clinical outcome of multiple myeloma.
18408561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18395509 two closely spaced thyroid hormone receptor/retinoid X receptor-binding clusters are both required for the maximal induction of MDR1 gene expression mediated by thyroid hormone receptor
18393221 nuclear and histological degree, and estrogens, progesterone and c-erb B2 receptors did not correlate with the SNP C3435T. Patients with complete pathological response (12.5%) showed only the polymorphic genotype and not the wild genotype
18393221 Observational study of gene-disease association. (HuGE Navigator)
18391751 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18389626 correlation between CIAPIN1 down regulation and decreased MDR1 transcriptional activity were observed.
18385010 Observational study of genetic testing. (HuGE Navigator)
18382661 Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18381794 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18379872 Our results show that ET-1 has no effect on Pgp expression of adult HBMECs, but does modulate Pgp transport activity.
18377430 Observational study of gene-disease association. (HuGE Navigator)
18348284 Biochemical alterations seen in AN patients could lead to increased expression and/or activity of P-gp and therefore to diminished access of drugs to the brain.
18344085 The protein expression rates of p-JNK and P-glycoprotein in gastric cancer were significantly higher than those in normal gastric tissue.
18340565 Clinical trial of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18338763 Observational study of gene-disease association. (HuGE Navigator)
18336668 Observational study of gene-disease association. (HuGE Navigator)
18334915 ABCB1 polymorphisms influence cyclosporine intracellular concentration in transplant recipients
18334915 Observational study of gene-disease association. (HuGE Navigator)
18334914 ABCB1 1236C-->T, 2677G-->T, and 3435C-->T variants and the associated TTT haplotype were associated with higher digoxin serum concentrations
18334914 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18329296 C3435T polymorphism of ABCB1 gene was demonstrated in vivo to significantly influence the CSF/S PB concentration ratio and seizure frequency.
18329296 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18324624 Following transient expression of MDR-1 and MCJ, changes in the sensitivity of Sk-Ov-3 cells to paclitaxel were detected whereas expression of Src, Bcl-2 and Bcl-X(L) decreased the sensitivity of Sk-Ov-3 cells to carboplatin.
18318115 Observational study of genotype prevalence. (HuGE Navigator)
18310046 The effects of zidovudine and stavudine on human cells, measuring their effects on the levels of mtDNA, mtRNA and on induction of the multidrug resistance (MDR) gene MDR-1.
18305404 These results indicate that mtDNA depletion can induce increased P-glycoprotein expression via an increase of mRNA stability and suggest that the mtDNA depletion in cancer cells plays an important role in the induction of multidrug resistance phenotype.
18303963 Self-identification according to the racial/color categories proposed by the Brazilian Census is insufficient to properly control for population stratification in pharmacogenomic studies of ABCB1.
18303963 Observational study of genotype prevalence. (HuGE Navigator)
18300948 ABCB1 SNPs may affect function of P-glycoprotein by influencing the expression level and modify breast cancer prognosis.
18300948 Observational study of gene-disease association. (HuGE Navigator)
18294295 Observational study of gene-disease association, gene-gene interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18287207 These functional data demonstrate that nonsynonymous polymorphisms in ABCB1 may selectively alter P-gp transport and drug-drug interactions in a substrate- and inhibitor-dependent manner.
18285546 Observational study of gene-disease association. (HuGE Navigator)
18280247 These results suggest that guggulsterone, a natural dietary hypolipidemic agent have dual inhibitory effects on P-gp and MRP1 and the potencies to cause food-drug interactions.
18279661 MDR1(+) cells had higher ability to form spheres in low attachment conditions, a hallmark of cancer. In conclusion, these novel findings imply that the MDR1(+) cells represent melanoma stem cells.
18272218 Complete remission rates and overall, relapse-free and event-free survival rates were not significantly different among the C3435T polymorphism of the MDR1 genotypes.
18272218 Observational study of gene-disease association. (HuGE Navigator)
18257092 Single nucleotide polymorphisms in multidrug resistance-1 was associated with central side effects to morphine in cancer patients
18257092 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18243305 While the distribution of individual alleles and genotypes did not differ between patients and controls, there were significant differences in the frequencies of some rare haplotypes and genotype combinations in the MDR1 gene between the two groups.
18243305 Observational study of gene-disease association. (HuGE Navigator)
18240903 Observational study of genotype prevalence. (HuGE Navigator)
18231753 Multidrug resistance induced by cisplatin in ovarian carcinoma cell lines is not due to overexpression of MDR1 and MDR3 genes.
18223462 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18223457 Observational study of genotype prevalence. (HuGE Navigator)
18221820 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18215618 This study indicate that the combined consideration of both the medication's capacity to act as an ABCB1-transporter substrate and the patient's ABCB1 genotype are strong predictors for achieving a remission.
18215618 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18214345 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18200595 Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.
18195061 Anionic drug salinomycin is a substrate for p-gp.
18192894 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18165917 investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration
18165917 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18095031 Observational study of gene-disease association. (HuGE Navigator)
18095031 the present study highly suggest that GSTP1, MDR1, and MTHFR genotypes could be prognostic factors for Taiwanese patients with breast cancer.
18091560 gp is expressed early during human cerebral cortical microvessel development, and suggest that at midgestation there may be efflux activity that is regulated by interactions with the caveolar endothelial cell compartment.
18090046 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18088459 Heat shock and ADM chemotherapy both induce over expression of HSP70 and MDR1.
18086475 Possible genes for antipsychotic treatment response were the dopamine D2 receptor gene (DRD2), the serotonin 2A and 2C receptor genes (HTR2A and HTR2C), the P-glycoprotein gene (ABCB1 or MDR1) and the drug-metabolizing cytochrome P450 2D6 gene (CYP2D6).
18086475 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18080812 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18075465 Promoter polymorphisms and allelic imbalance influence ABCB1 mRNA expression
18059532 These findings suggest that downregulating CIAPIN1 could sensitize leukemia cells to chemotherapeutic drugs by downregulating MDR-1 and Bcl-2 and by upregulating Bax.
18058465 DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1.
18058211 review potential importance of SNPs in MDR
18056183 Observational study of gene-disease association. (HuGE Navigator)
18035065 Data show that exposing cells to the glucosylceramide synthase inhibitor, ethylenedioxy-P4, prevented ceramide's enhancement of MDR1 expression.
18028890 Observational study of genetic testing. (HuGE Navigator)
18004247 MDR1 expression might have significant prognostic value in patients suffering from metastatic non-seminomas
18003760 R230C/C230C genotypes were significantly more frequent in type 2 diabetic individuals than in control subjects in Mexicans.
18003606 a functional interplay between membrane Gb3 and MDR1 provides a more physiologically based approach to MDR1 regulation to increase the bioavailability of chemotherapeutic drugs.
18001833 MDR1 promoter polymorphism is not associated with its activity and protein expression in acute myeloid leukemia
17963743 Examine interactions of agents used to treat attention-deficit/hyperactivity disorder with P-glycoprotein.
17956668 The expression of P-gp and mdr1 were positively correlated with NF-kappaB/p65.
17955490 report the cloning and characterization of the MDR1 upstream promoter and studied its association with chemotherapy response in breast cancer patients
17954267 Treatment with the anti-cancer drug paclitaxel have an increased copy number in the 7q21.12 region including the MDR1/ABCB1 gene.
17952118 Upregulation of MDR1 by DeltaNp73alpha is mediated by interaction with p53 at the MDR1 promoter.
17943188 Pgp is involved in migration and invasion of resistant melanoma cells.
17940136 ABCB1 3'-UTR variants have no effect on ABCB1 mRNA stability
17938643 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17934801 P-gp, rather than BCRP or OCT1, is partially responsible for the development of imatinib-resistance due to constitutive and functional overexpression, leading to reduced intracellular accumulation of imatinib in resistant K562 cells.
17925548 Observational study of gene-disease association. (HuGE Navigator)
17924830 Single nucleotide polymorphisms contribute to drug-resistant epilepsy.
17924830 Observational study of gene-disease association. (HuGE Navigator)