| Tbio | ATP-binding cassette sub-family A member 3 |
Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Emphysema | 12 | 0.0 | 0.0 |
| Hypertension, Pulmonary | 37 | 0.0 | 0.0 |
| Pulmonary Fibrosis | 106 | 0.0 | 0.0 |
| Surfactant Metabolism Dysfunction, Pulmonary, 3 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.2e-27 |
| lung carcinoma | 2843 | 8.1e-21 |
| psoriasis | 6694 | 1.5e-08 |
| ependymoma | 4679 | 4.4e-07 |
| malignant mesothelioma | 3232 | 1.2e-06 |
| lung cancer | 4740 | 8.7e-06 |
| lung adenocarcinoma | 2716 | 1.1e-05 |
| pediatric high grade glioma | 1064 | 7.2e-05 |
| glioblastoma | 5792 | 4.1e-04 |
| primitive neuroectodermal tumor | 3035 | 7.0e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.1e-02 |
| nasopharyngeal carcinoma | 1058 | 2.3e-02 |
| Disease | Target Count |
|---|---|
| Interstitial lung disease due to ABCA3 deficiency | 1 |
| Pulmonary Fibrosis, Idiopathic | 12 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | -1.100 | 4.4e-07 |
| glioblastoma | -1.300 | 4.1e-04 |
| lung adenocarcinoma | -1.300 | 1.1e-05 |
| lung cancer | -2.100 | 8.7e-06 |
| lung carcinoma | -1.300 | 8.1e-21 |
| malignant mesothelioma | 1.400 | 1.2e-06 |
| nasopharyngeal carcinoma | 1.200 | 2.3e-02 |
| non-small cell lung cancer | -2.582 | 4.2e-27 |
| pediatric high grade glioma | -1.100 | 7.2e-05 |
| primary pancreatic ductal adenocarcinoma | -1.137 | 1.1e-02 |
| primitive neuroectodermal tumor | -1.200 | 7.0e-04 |
| psoriasis | -1.200 | 1.5e-08 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFFT 1 - 70 FPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFN 71 - 140 HSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREG 141 - 210 FLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIAR 211 - 280 AVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFL 281 - 350 LCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 351 - 420 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMP 421 - 490 SYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQ 491 - 560 ITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFY 561 - 630 AQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISR 631 - 700 RAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNP 701 - 770 EDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVG 771 - 840 KLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWA 841 - 910 MFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQ 911 - 980 QLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSP 981 - 1050 ATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAV 1051 - 1120 SERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGW 1121 - 1190 AIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMA 1191 - 1260 VSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQ 1261 - 1330 RLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVD 1331 - 1400 RLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDH 1401 - 1470 MTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDE 1471 - 1540 PSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS 1541 - 1610 LRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSV 1611 - 1680 SQISLEQVFLSFAHLQPPTAEEGR 1681 - 1704 //
