Tbio AATF Protein AATF

Protein Summary

Description

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NY61
• A6NCJ6
• B3KQ26
• Q9P0A4
• Q9UNX5

Gene Name

• AATF

Ensembl ID

• ENST00000619387
• ENSP00000477848
• ENSG00000275700
• ENST00000620004
• ENSP00000481894
• ENSG00000276072

Symbol

• CHE1
• DED
• DED
• BFR2
• CHE1
• CHE-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
co-expressed gene	0.89
transcription factor binding site profile	0.89
hub protein	0.88
cellular component	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Aatf

DTO Classes

Protein / Transcription Factor / Protein Aatf

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.21   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 299   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.21   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0