Tbio AAMP Angio-associated migratory cell protein

Protein Summary

Description

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q13685
• Q8WUJ9
• Q96H92

Gene Name

• AAMP

Ensembl ID

• ENST00000248450
• ENSP00000248450
• ENSG00000127837

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
kinase perturbation	0.81
gene perturbation	0.76
transcription factor binding site profile	0.71
interacting protein	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.19   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.19   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0