Tbio CAPN14 Calpain-14

Protein Summary

Description

Calcium-regulated non-lysosomal thiol-protease. Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• A8MX76
• B3KRU9

Gene Name

• CAPN14

Ensembl ID

• ENST00000403897
• ENSP00000385247
• ENSG00000214711

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
cell line	0.71
tissue sample	0.62
microRNA	0.56
molecular function	0.49

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Calpain-14

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calpain-14

Protein / Calcium-binding Protein / Annexin / Calpain-14

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Calpain-14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.12   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0