Property Summary

NCBI Gene PubMed Count 16
Grant Count 7
R01 Count 5
Funding $1,487,355.8
PubMed Score 5.02
PubTator Score 27.25

Knowledge Summary


No data available


  Differential Expression (6)

Disease log2 FC p
psoriasis 1.800 0.000
tuberculosis 1.500 0.000
lung cancer 1.700 0.000
lung adenocarcinoma 1.100 0.000
invasive ductal carcinoma 1.700 0.000
Breast cancer 1.100 0.000


Accession A8MT69 O00281 O00282 Q96DD4 Q96F51 CENP-X
Symbols D9



4DRA   4DRB   4E44   4E45   4NDY   4NE1   4NE3   4NE5   4NE6  

 GO Function (1)

Gene RIF (10)

24699063 The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA.
24522885 CENPX assembly in living human cells, revealing a window in S phase and G2 in which de novo assembly of the complex from a soluble precursor occurs through a dynamic exchange mechanism.
24390579 MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage.
24256282 It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.
23886707 A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin.
22510687 MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure.
20416077 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20347429 provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.
19620631 Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X [Stra13]
8839844 Identification of human and mouse homologs of clone D9 of a murine promyelocyte cell line that was upregulated by retinoic acid.

AA Sequence

EKVLPQLLLDF                                                                71 - 81

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25038251 2014 FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers.
24699063 2014 The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.
24522885 2014 A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.
24390579 2014 The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
24256282 2013 Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.
23886707 2013 Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22510687 2012 The structure of the FANCM-MHF complex reveals physical features for functional assembly.
22304917 2012 CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.