Tbio IFITM5 Interferon-induced transmembrane protein 5

Protein Summary

Description

Required for normal bone mineralization. This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• A6NNB3

Gene Name

• IFITM5

Ensembl ID

• ENST00000382614
• ENSP00000372059
• ENSG00000206013

Symbol

• OI5
• BRIL
• DSPA1
• Hrmp1
• fragilis4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.58
cell line	0.49
PubMedID	0.49
transcription factor binding site profile	0.41
cell type or tissue	0.39

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.9   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.9   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0