Tdark GJE1 Putative gap junction epsilon-1 protein

Protein Summary

Description

Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions.

Uniprot Accession IDs

• A6NN92

Gene Name

• GJE1

Ensembl ID

• ENST00000450456
• ENSP00000455469
• ENSG00000203733

Symbol

• CX23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.46
ligand (chemical)	0.34
phenotype	0.33
disease	0.28
microRNA	0.24

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Gap Junction / Putative Gap Junction Epsilon-1 Protein

DTO Classes

Protein / Cell-cell Junction / Gap Junction / Putative Gap Junction Epsilon-1 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.25   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.25   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0