Tdark TTC36 Tetratricopeptide repeat protein 36

Protein Summary

Description

The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• A6NLP5
• B7ZW72
• B9EJD8
• TPR repeat protein 36

Gene Name

• TTC36

Ensembl ID

• ENST00000302783
• ENSP00000307640
• ENSG00000172425

Symbol

• HBP21
• HBP21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
gene perturbation	0.54
tissue sample	0.5
cellular component	0.44
disease perturbation	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0