Tdark FBLL1 rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).

Uniprot Accession IDs

• A6NHQ2
• R4GMW7

Gene Name

• FBLL1

Ensembl ID

• ENST00000338333
• ENSP00000473383
• ENSG00000188573

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.94
histone modification site profile	0.65
disease	0.6
protein complex	0.48
tissue	0.46

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rrna/trna 2'-o-methyltransferase Fibrillarin-like Protein 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Rrna/trna 2'-o-methyltransferase Fibrillarin-like Protein 1

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Rrna/trna 2'-o-methyltransferase Fibrillarin-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 5   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0