Tdark TBC1D3B TBC1 domain family member 3B

Protein Summary

Description

Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• A6NDS4
• A8K892

Gene Name

• TBC1D3B

Ensembl ID

• ENST00000611257
• ENSP00000478473
• ENSG00000274808

Symbol

• TBC1D3I
• PRC17
• TBC1D3I
• TBC1D3L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.57
tissue	0.45
cell type or tissue	0.38
cell line	0.36
microRNA	0.33

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 3b

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 3b

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 3b

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 8   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0