| Tbio | PH and SEC7 domain-containing protein 1 |
Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity).
This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 8.396245600099E-29 |
| posterior fossa group A ependymoma | 1511 | 3.03223676907134E-12 |
| atypical teratoid / rhabdoid tumor | 4369 | 1.25696250172298E-9 |
| glioblastoma | 5572 | 6.5423998754573E-7 |
| pilocytic astrocytoma | 3086 | 9.94493718972646E-6 |
| medulloblastoma | 1524 | 3.48823428108849E-5 |
| adult high grade glioma | 2148 | 9.43836066600539E-5 |
| medulloblastoma, large-cell | 6234 | 3.1879733402949E-4 |
| primitive neuroectodermal tumor | 3031 | 0.00573889957454138 |
| astrocytoma | 1493 | 0.00983669795149211 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Branch retinal artery occlusion | 3 | 5.04 | 2.5 |
| Central retinal artery occlusion | 3 | 3.364 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| posterior fossa group A ependymoma | -2.100 | 0.000 |
| astrocytoma | -1.800 | 0.010 |
| glioblastoma | -2.200 | 0.000 |
| medulloblastoma | -1.400 | 0.000 |
| atypical teratoid / rhabdoid tumor | -2.300 | 0.000 |
| medulloblastoma, large-cell | -1.900 | 0.000 |
| primitive neuroectodermal tumor | -1.200 | 0.006 |
| adult high grade glioma | -2.000 | 0.000 |
| pilocytic astrocytoma | -1.500 | 0.000 |
| lung carcinoma | 1.300 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG Inparanoid |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG |
| Pig | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Anole lizard | OMA Inparanoid |
| Zebrafish | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26330566 | Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. |
| 25355626 | PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. |
| 25114232 | EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially |
| 23603394 | EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. |
| 22179719 | Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. |
| 22002136 | Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. |
| 19773279 | Observational study of gene-disease association. (HuGE Navigator) |
| 17579087 | Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. |
| 16385451 | Observational study of gene-disease association. (HuGE Navigator) |
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPL 1 - 70 RGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPA 71 - 140 LGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGP 141 - 210 ADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRA 211 - 280 AKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNE 281 - 350 DEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY 351 - 420 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEAR 421 - 490 AKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQR 491 - 560 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLA 561 - 630 HFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALY 631 - 700 SSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHAD 701 - 770 PDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR 771 - 840 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAK 841 - 910 LKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQA 911 - 980 GSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSGRRKP 981 - 1024 //
| PMID | Year | Title |
|---|---|---|
| 26330566 | 2016 | Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. |
| 25355626 | 2015 | The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance. |
| 25114232 | 2014 | EFA6 controls Arf1 and Arf6 activation through a negative feedback loop. |
| 23603394 | 2013 | EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. |
| 23535732 | 2013 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. |
| 22179719 | 2012 | Aberrant methylation of PSD disturbs Rac1-mediated immune responses governing neutrophil chemotaxis and apoptosis in ulcerative colitis-associated carcinogenesis. |
| 22002136 | 2012 | Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis. |
| 20339350 | 2010 | USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. |
| 19773279 | 2009 | Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. |
| 19494129 | 2009 | EFA6A encodes two isoforms with distinct biological activities in neuronal cells. |
| More... |
