Tchem PSD PH and SEC7 domain-containing protein 1

Protein Summary

Description

Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• A5PKW4
• B1AKX7
• D3DR87
• Q15673
• Q8IVG0

Gene Name

• PSD

Ensembl ID

• ENST00000020673
• ENSP00000020673
• ENSG00000059915
• ENST00000406432
• ENSP00000384830
• ENST00000611678
• ENSP00000481250

Symbol

• EFA6
• EFA6A
• KIAA2011
• PSD1
• TYL
• TYL
• EFA6
• PSD1
• EFA6A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.87
disease perturbation	0.79
transcription factor	0.76
protein domain	0.73
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.84   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.84   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0