| Tbio | PH and SEC7 domain-containing protein 1 |
Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity).
This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 8.4e-29 |
| astrocytoma | 1146 | 2.3e-18 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.3e-09 |
| glioblastoma | 5792 | 1.0e-07 |
| Astrocytoma, Pilocytic | 3081 | 9.7e-06 |
| medulloblastoma | 720 | 8.9e-05 |
| adult high grade glioma | 3801 | 9.4e-05 |
| medulloblastoma, large-cell | 6241 | 3.2e-04 |
| ependymoma | 4679 | 4.8e-03 |
| primitive neuroectodermal tumor | 3035 | 5.7e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Branch retinal artery occlusion | 3 | 5.023 | 2.5 |
| Central retinal artery occlusion | 3 | 3.226 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.000 | 9.4e-05 |
| astrocytoma | -1.100 | 2.3e-18 |
| Astrocytoma, Pilocytic | -1.500 | 9.7e-06 |
| atypical teratoid / rhabdoid tumor | -2.300 | 1.3e-09 |
| ependymoma | -1.200 | 4.8e-03 |
| glioblastoma | -1.500 | 1.0e-07 |
| lung carcinoma | 1.300 | 8.4e-29 |
| medulloblastoma | -1.100 | 8.9e-05 |
| medulloblastoma, large-cell | -1.900 | 3.2e-04 |
| primitive neuroectodermal tumor | -1.200 | 5.7e-03 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA |
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGRELGRVTAPCTPL 1 - 70 RGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAPGGLSRSWDLGGVSPPRPTPA 71 - 140 LGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAPPQVGADGLYSSLPNGLGGPPERLATLFGGP 141 - 210 ADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRA 211 - 280 AKYSETDLDTVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNE 281 - 350 DEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY 351 - 420 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRGEEEEAEAR 421 - 490 AKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQR 491 - 560 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLA 561 - 630 HFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALY 631 - 700 SSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHAD 701 - 770 PDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR 771 - 840 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAK 841 - 910 LKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQA 911 - 980 GSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSGRRKP 981 - 1024 //
