Tbio CFAP69 Cilia- and flagella-associated protein 69

Protein Summary

Description

Cilium- and flagellum-associated protein (PubMed:29606301). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (PubMed:29606301).

Uniprot Accession IDs

• A5D8W1
• A3KMP9
• B4DYW6
• B4DZP7
• B9EIM7
• Q6V705
• Q8IY89
• Q9H7C2

Gene Name

• CFAP69

Ensembl ID

• ENST00000389297
• ENSP00000373948
• ENSG00000105792
• ENST00000451029
• ENSP00000411234
• ENST00000497910
• ENSP00000419549

Symbol

• C7orf63
• FAP69
• SPGF24
• C7orf63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
histone modification site profile	0.84
cell type or tissue	0.82
tissue sample	0.64
small molecule perturbation	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0