Tbio CCDC66 Coiled-coil domain-containing protein 66

Protein Summary

Description

Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Plays a role in retina morphogenesis and/or homeostasis (By similarity).

Uniprot Accession IDs

• A2RUB6
• B3KWL8
• Q4VC34
• Q8N949

Gene Name

• CCDC66

Ensembl ID

• ENST00000326595
• ENSP00000326050
• ENSG00000180376
• ENST00000394672
• ENSP00000378167

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.88
histone modification site profile	0.83
tissue sample	0.62
virus perturbation	0.55
transcription factor binding site profile	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0