Tdark MEIOC Meiosis-specific coiled-coil domain-containing protein MEIOC

Protein Summary

Description

Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.

Uniprot Accession IDs

• A2RUB1
• B4DXJ2
• B5MD93
• B9EGQ6
• C4AM97
• Q4G0Y1
• Q8IVZ7
• Q8NA45

Gene Name

• MEIOC

Ensembl ID

• ENST00000409122
• ENSP00000386452
• ENSG00000180336
• ENST00000409464
• ENSP00000386586

Symbol

• C17orf104
• C17orf104

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 37   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0