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Tbio
ZC3H12D
Probable ribonuclease ZC3H12D

Protein Summary
Description
May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409806
  • ENSP00000386616
  • ENSG00000178199

Symbol
  • C6orf95
  • MCPIP4
  • TFL
  • TFL
  • p34
  • MCPIP4
  • C6orf95
  • dJ281H8.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.72
cell type or tissue
0.69
tissue sample
0.56
cellular component
0.55
phenotype
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0