Tbio | Immunity-related GTPase family M protein |
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Crohn's disease | 304 | 5.993 | 3.0 |
Inflammatory bowel disease | 142 | 0.0 | 2.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
tuberculosis | 1563 | 3.336 | 1.7 |
Disease | Target Count |
---|---|
Inflammatory bowel disease 19 | 1 |
PMID | Text |
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26786655 | IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population. |
26066377 | The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings. |
25944217 | In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively. |
25891078 | Data indicate that immunity-related GTPase family M (IRGM) plays a direct role in organizing the core autophagy machinery to endow it with antimicrobial and anti-inflammatory functions. |
25891078 | IRGM assembles core autophagy machinery (Beclin 1, Ulk1, ATG16L1) and connects it with innate immunity sensors (NOD2) through formation of protein complex assemblies. |
25891078 | RGM directly organizes the core autophagy machinery and links it with antimicrobial and anti-inflammatory functions. IRGM interacts with ULK1 and Beclin 1 promoting their co-assembly into autophagy initiation complexes. All three Crohn's disease risk factors, IRGM, NOD2 and ATG16L1, form a complex. NOD2 enhances K63-polyubiquitination of IRGM, promoting IRGM assembly with core autophagy regulators. |
25853521 | Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy. |
25707354 | Our findings suggest that expression of IRGM is dysregulated in gastric cancer and that the molecule may affect progression of the disease. |
25619828 | these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy |
25526194 | The IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of Crohn's disease. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of Crohn's disease risk. |
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PMID | Year | Title |
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26786655 | 2016 | IRGM gene polymorphisms and haplotypes associate with susceptibility of pulmonary tuberculosis in Chinese Hubei Han population. |
26066377 | 2015 | Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease. |
25944217 | 2015 | Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease. |
25891078 | 2015 | IRGM governs the core autophagy machinery to conduct antimicrobial defense. |
25853521 | 2015 | Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways. |
25707354 | 2015 | Elevated expression of immunity-related GTPase family M in gastric cancer. |
25619828 | 2015 | IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy. |
25526194 | 2014 | Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies. |
25191865 | 2014 | Association of IRGM gene mutations with inflammatory bowel disease in the Indian population. |
24859836 | 2014 | Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions. |
More... |