| Tbio | Immunity-related GTPase family M protein |
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colitis, Ulcerative | 59 | 0.0 | 0.0 |
| Crohn Disease | 45 | 0.0 | 0.0 |
| Generalized Epilepsy With Febrile Seizures Plus, Type 6 | 1 | 0.0 | 0.0 |
| Inflammatory Bowel Diseases | 35 | 0.0 | 0.0 |
| Inflammatory bowel disease 19 | 2 | 0.0 | 0.0 |
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO | 11 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| ulcerative colitis | 1819 |
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 11 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Crohn's disease | 321 | 6.017 | 3.0 |
| Inflammatory bowel disease | 151 | 0.0 | 2.1 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Inflammatory bowel disease 5 | 14 | 4.362 | 2.2 |
| tuberculosis | 2010 | 3.476 | 1.7 |
