Tbio ARHGAP10 Rho GTPase-activating protein 10

Protein Summary

Description

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Uniprot Accession IDs

• A1A4S6
• A1L0S5
• Q2VPC4
• Q2VPC5
• Q96EV3
• Q96S75

Gene Name

• ARHGAP10

Ensembl ID

• ENST00000336498
• ENSP00000336923
• ENSG00000071205

Symbol

• GRAF2
• GRAF2
• PSGAP
• PS-GAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
drug perturbation	0.87
histone modification site profile	0.79
kinase perturbation	0.76
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 10

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.31   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.31   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0