Tbio FEZF1 Fez family zinc finger protein 1

Protein Summary

Description

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• A0PJY2
• A0PJY3
• A4D0W3
• B4DUP9
• B7ZM98

Gene Name

• FEZF1

Ensembl ID

• ENST00000427185
• ENSP00000392727
• ENSG00000128610
• ENST00000442488
• ENSP00000411145

Symbol

• FEZ
• ZNF312B
• FEZ
• HH22
• ZNF312B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.8
molecular function	0.67
cell type or tissue	0.56
tissue	0.51
gene perturbation	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.48   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.48   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0