Tbio SLC5A10 Sodium/glucose cotransporter 5

Protein Summary

Description

High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• A0PJK1
• A8MUC9
• B4DPI0
• B7WPR4
• Q6P5X0
• Q8IXM4
• Q96LQ1
• Na(+)/glucose cotransporter 5

Gene Name

• SLC5A10

Ensembl ID

• ENST00000317977
• ENSP00000324346
• ENSG00000154025
• ENST00000395643
• ENSP00000379005
• ENST00000395645
• ENSP00000379007
• ENST00000395647
• ENSP00000379008
• ENST00000417251
• ENSP00000401875

Symbol

• SGLT5
• SGLT5
• SGLT-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.76
cell line	0.56
tissue	0.47
metabolite	0.45
phenotype	0.42

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium/glucose Cotransporter 5

Protein / Transporter / Carbohydrate Transporter / Sodium/glucose Cotransporter 5

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc5 Family Of Sodium-dependent Glucose Transporters / Hexose Transporter Family / Sodium/glucose Cotransporter 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0