Property Summary

NCBI Gene PubMed Count 20
PubMed Score 7.32
PubTator Score 10.65

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
juvenile dermatomyositis 1189 2.31126532949965E-10
osteosarcoma 7933 7.32917191307897E-8
medulloblastoma 1524 1.35468267961654E-7
non-small cell lung cancer 2798 1.26711500286495E-5
posterior fossa group A ependymoma 1511 1.81991118215357E-5
Pick disease 1893 4.39581043927287E-5
atypical teratoid / rhabdoid tumor 4369 1.17122804146299E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.69090549633091E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 3.56055005442695E-4
primitive neuroectodermal tumor 3031 3.79727445951736E-4
pilocytic astrocytoma 3086 6.99708672556042E-4
primary Sjogren syndrome 789 7.19087263126453E-4
medulloblastoma, large-cell 6234 9.23241008737992E-4
psoriasis 6685 9.59044571941E-4
Atopic dermatitis 944 0.00448904719014106
ovarian cancer 8492 0.00814199974547884
active Crohn's disease 918 0.00909103646330896
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00951499403555112
adrenocortical carcinoma 1427 0.0132039531118131
progressive supranuclear palsy 674 0.013901844314811
Rheumatoid Arthritis 1171 0.0188682149376103
subependymal giant cell astrocytoma 2287 0.0409612015353854
Gaucher disease type 1 171 0.0458007643154135

Expression

Gene

PANTHER Protein Class (1)

  Ortholog (13)

Gene RIF (7)

PMID Text
26284580 Interstitial microdeletions including the chromosome band 4q13.2 and the UBA6 gene as possible causes of intellectual disability and behavior disorder.
22999844 Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6.
22427669 Data indicate the potential role of cytokine-induced FAT10 expression in regulating Uba6 pathways.
18353650 Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10[review]
17889673 The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported.
17597759 Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s
17580310 UBE1L2 is a novel E1 enzyme specific for ubiquitin

AA Sequence

MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMG      1 - 70
GLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSV     71 - 140
PFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTG    141 - 210
EEPKEIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELE    211 - 280
PYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQD    281 - 350
SEELLKLATSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE    351 - 420
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEK    421 - 490
GMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTK    491 - 560
QDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSF    561 - 630
PAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCV    631 - 700
ELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYC    701 - 770
IPFAEEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS    771 - 840
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMI    841 - 910
KVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHGKEDFTLLDFINAVKEKYG    911 - 980
IEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKKYVDLTVSFAPDIDGDEDLPGPPVRYYFSHD    981 - 1050
TD                                                                       1051 - 1052
//

Text Mined References (26)

PMID Year Title
26284580 2015 Interstitial microdeletions including the chromosome band 4q13.2 and the UBA6 gene as possible causes of intellectual disability and behavior disorder.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22999844 2012 The Escherichia coli adherence factor plasmid of enteropathogenic Escherichia coli causes a global decrease in ubiquitylated host cell proteins by decreasing ubiquitin E1 enzyme expression through host aspartyl proteases.
22427669 2012 Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.
21269460 2011 Initial characterization of the human central proteome.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18353650 2008 Activating the ubiquitin family: UBA6 challenges the field.
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