Development Level

Tclin 130,166
Tchem 105,938

Target Family

Enzyme 85,645
GPCR 59,407
Kinase 33,996
Ion Channel 16,788
Non-IDG 16,175
Transporter 9,204
Nuclear Receptor 7,246
Epigenetic 5,140
Transcription Factor 410
TF/Epigenetic 108

Target

KCNH2 4,432
CA2 4,185
F10 3,879
BACE1 3,691
SLC6A4 3,433
DPP4 3,107
SCN9A 2,970
F2 2,721
PDE10A 2,702
CA1 2,654
HSD11B1 2,493
DRD2 2,432
DRD3 2,406
CA9 2,402
REN 2,303
MAPT 2,286
HDAC1 2,280
HRH3 2,278
MMP2 2,249
SLC6A2 2,227
HTR1A 2,209
HTR2A 2,122
MCHR1 2,039
MMP13 2,036
CA12 2,010
HTR6 2,009
ACACB 1,930
CNR2 1,926
ACHE 1,877
ALOX5AP 1,860
SIGMAR1 1,854
TACR1 1,853
MMP9 1,834
OPRM1 1,833
ADORA3 1,774
SLC6A3 1,766
MTOR 1,755
KDR 1,715
OPRK1 1,683
PARP1 1,628
OPRD1 1,607
ADORA2A 1,585
PTGS2 1,569
CTSS 1,565
CNR1 1,548
NR3C1 1,509
MMP1 1,452
MDM2 1,448
EGFR 1,445
TRPV1 1,427
P2RX7 1,410
CTSK 1,400
HDAC6 1,390
EPHX2 1,376
PIK3CA 1,366
JAK2 1,350
MMP3 1,345
MAPK14 1,345
PTGDR2 1,332
DRD4 1,320
MET 1,273
HTR2C 1,221
CCR5 1,197
ADAM17 1,190
ADORA1 1,178
CRHR1 1,163
CYP19A1 1,140
PIM1 1,138
PDE5A 1,120
JAK1 1,095
MAOB 1,065
ADRA1A 1,054
MC4R 1,053
BRAF 1,020
PPARG 980
ELANE 979
HTR7 976
ESR1 967
OPRL1 958
CHRM3 950
SLC5A2 950
BCL2 932
ESR2 923
FAAH 912
ADORA2B 900
AURKA 898
MMP8 878
SYK 864
CHEK1 863
HCRTR2 854
CCR2 843
P2RX3 830
HTR1D 824
BCHE 816
PDE4B 813
S1PR1 810
AR 796
PRSS1 792
TDP1 782
CTSL 778

Pharmalogical Action

INHIBITOR 542
AGONIST 427
ANTAGONIST 350
BLOCKER 129
ANTIBODY BINDING 57
POSITIVE ALLOSTERIC MODULATOR 51
ACTIVATOR 30
MODULATOR 20
OPENER 16
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 9
GATING INHIBITOR 6
NEGATIVE ALLOSTERIC MODULATOR 5
RELEASING AGENT 5
SUBSTRATE 5
ALLOSTERIC MODULATOR 4
PHARMACOLOGICAL CHAPERONE 3
ALLOSTERIC ANTAGONIST 2
OTHER 1

Ligand Activity

IC50 143,077
Ki 70,819
EC50 8,212
Potency 2,975
Kd 2,908
- 698
AC50 517
KB 17

Ligand Activity Source

ChEMBL 220,950
Guide to Pharmacology 5,022

Ligand Source

CHEMBL 221,632
Guide to Pharmacology 5,022
SCIENTIFIC LITERATURE 269
DRUG LABEL 243
IUPHAR 129
KEGG DRUG 45