Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 125,777
Tchem 105,055

Target Family

Enzyme 84,852
GPCR 57,172
Kinase 33,171
Ion Channel 16,380
Non-IDG 16,159
Transporter 9,041
Nuclear Receptor 6,984
Epigenetic 4,988
Transcription Factor 415
TF/Epigenetic 101
oGPCR 1

Pharmalogical Action

INHIBITOR 454
AGONIST 399
ANTAGONIST 310
BLOCKER 116
ANTIBODY BINDING 55
POSITIVE ALLOSTERIC MODULATOR 44
ACTIVATOR 27
MODULATOR 20
OPENER 17
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 221,382
SCIENTIFIC LITERATURE 214
DRUG LABEL 167
IUPHAR 73
KEGG DRUG 38

Ligand Activity

IC50 141,091
Ki 69,794
EC50 7,770
Potency 2,975
Kd 2,647
AC50 517

Target

KCNH2 4,416
CA2 4,179
F10 3,874
BACE1 3,667
SLC6A4 3,404
DPP4 3,093
SCN9A 2,961
F2 2,715
PDE10A 2,698
CA1 2,641
HSD11B1 2,490
CA9 2,401
DRD2 2,365
DRD3 2,357
REN 2,302
MAPT 2,286
HDAC1 2,252
MMP2 2,243
HRH3 2,231
SLC6A2 2,194
HTR1A 2,121
MMP13 2,029
MCHR1 2,026
HTR2A 1,997
CA12 1,996
HTR6 1,944
ACACB 1,928
CNR2 1,908
ACHE 1,866
ALOX5AP 1,860
SIGMAR1 1,848
TACR1 1,832
MMP9 1,826
OPRM1 1,773
SLC6A3 1,746
MTOR 1,724
ADORA3 1,686
KDR 1,651
OPRK1 1,626
PARP1 1,622
CTSS 1,561
OPRD1 1,561
PTGS2 1,542
CNR1 1,517
ADORA2A 1,511
NR3C1 1,480
MDM2 1,448
MMP1 1,448
P2RX7 1,398
TRPV1 1,397
CTSK 1,395
EGFR 1,393
EPHX2 1,366
HDAC6 1,363
MMP3 1,342
MAPK14 1,320
JAK2 1,316
PIK3CA 1,312
PTGDR2 1,309
DRD4 1,271
MET 1,247
CCR5 1,186
ADAM17 1,185
CRHR1 1,161
HTR2C 1,154
CYP19A1 1,133
PIM1 1,122
PDE5A 1,107
ADORA1 1,099
JAK1 1,066
MAOB 1,056
MC4R 1,050
ADRA1A 1,014
BRAF 1,004
ELANE 974
ESR1 945
OPRL1 944
SLC5A2 944
BCL2 930
PPARG 928
HTR7 911
ESR2 901
FAAH 900
CHRM3 895
MMP8 874
AURKA 870
SYK 848
CHEK1 847
HCRTR2 837
ADORA2B 834
CCR2 829
P2RX3 822
BCHE 813
PDE4B 804
PRSS1 789
S1PR1 786
TDP1 782
CTSL 776
AR 775
HTR1D 770