Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 15
Tchem 2

Target Family

Ion Channel 15
Enzyme 2
Non-IDG 2

Pharmalogical Action

POSITIVE MODULATOR 15
INHIBITOR 454
AGONIST 399
ANTAGONIST 310
BLOCKER 116
ANTIBODY BINDING 55
POSITIVE ALLOSTERIC MODULATOR 44
ACTIVATOR 27
MODULATOR 20
OPENER 17
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 13
DRUG LABEL 2

Ligand Activity

EC50 2
IC50 1
Ki 1
Potency 1

Target

GABRA1 12
GABRG2 12
GABRB3 10
GABRB2 9
GABRA3 7
GABRA5 7
GABRG3 7
GABRA2 6
GABRA4 6
GABRA6 6
GABRB1 6
GABRD 6
GABRE 6
GABRG1 6
GABRP 6
GABRQ 6
GLRA1 6
KCNK10 5
KCNK18 5
KCNK2 5
KCNK3 5
KCNK9 5
GLRB 3
CFTR 2
CA1 1
CA12 1
CA13 1
CA2 1
CA4 1
CA5A 1
CA5B 1
CA6 1
CA7 1
CA9 1
CYP11B1 1
CYP11B2 1
GRIA1 1
GRIA2 1
GRIA3 1
GRIA4 1
GRIK1 1
GRIK2 1
GRIK3 1
GRIK4 1
GRIK5 1
GRIN1 1
GRIN2A 1
GRIN2B 1
GRIN2C 1
GRIN2D 1
GRIN3A 1
GRIN3B 1
MAPT 1
SCN1A 1
SCN5A 1