Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 2 | 855
Selleck FDA Approved Drug 2 | 410
NCATS MIPE 1 | 567
Selleck Target Selective Inhibitor 1 | 213

Development Level

Tclin 14 | 127,306
Tchem 2 | 103,180

Target Family

Ion Channel 14 | 16,308
Enzyme 2 | 84,773
Non-IDG 2 | 16,032

Target

GABRA1 12 | 139
GABRG2 12 | 48
GABRB3 10 | 52
GABRB2 9 | 37
GABRA3 7 | 61
GABRA5 7 | 472
GABRG3 7 | 17
GABRA2 6 | 131
GABRA4 6 | 20
GABRA6 6 | 24
GABRB1 6 | 14
GABRD 6 | 13
GABRE 6 | 10
GABRG1 6 | 13
GABRP 6 | 10
GABRQ 6 | 10
GLRA1 6 | 31
KCNK10 5 | 6
KCNK18 5 | 5
KCNK2 5 | 18
KCNK3 5 | 102
KCNK9 5 | 46
GLRB 3 | 3
CA1 1 | 2,641
CA12 1 | 1,996
CA13 1 | 139
CA2 1 | 4,179
CA4 1 | 235
CA5A 1 | 137
CA5B 1 | 101
CA6 1 | 98
CA7 1 | 442
CA9 1 | 2,401
CFTR 1 | 176
CYP11B1 1 | 483
CYP11B2 1 | 707
GRIA1 1 | 75
GRIA2 1 | 164
GRIA3 1 | 18
GRIA4 1 | 37
GRIK1 1 | 152
GRIK2 1 | 81
GRIK3 1 | 16
GRIK4 1 | 1
GRIK5 1 | 21
GRIN1 1 | 55
GRIN2A 1 | 5
GRIN2B 1 | 118
GRIN2C 1 | 3
GRIN2D 1 | 4
GRIN3A 1 | 4
GRIN3B 1 | 3
MAPT 1 | 2,286
SCN1A 1 | 49
SCN5A 1 | 316

Pharmalogical Action

POSITIVE MODULATOR 14 | 14
INHIBITOR 471 | 471
AGONIST 405 | 405
ANTAGONIST 314 | 314
BLOCKER 117 | 117
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 41 | 41
ACTIVATOR 28 | 28
MODULATOR 19 | 19
OPENER 15 | 15
PARTIAL AGONIST 12 | 12
INVERSE AGONIST 8 | 8
GATING INHIBITOR 6 | 6
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
NEGATIVE ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 1 | 1
OTHER 1 | 1

Ligand Activity

EC50 1 | 7,763
IC50 1 | 141,067
Ki 1 | 69,787
Potency 1 | 2,975

Ligand Source

CHEMBL 13 | 221,399
DRUG LABEL 1 | 219