Development Level

Tclin 15 | 130,166
Tchem 3 | 105,938

Target Family

Ion Channel 15 | 16,788
Enzyme 2 | 85,645
Non-IDG 2 | 16,175

Target

GABRA1 12 | 147
GABRG2 12 | 48
GABRB2 9 | 37
GABRB3 9 | 53
GABRA3 7 | 68
GABRA5 7 | 481
GABRA2 6 | 139
GABRA4 6 | 21
GABRA6 6 | 25
GABRB1 6 | 14
GABRD 6 | 13
GABRE 6 | 10
GABRG1 6 | 13
GABRG3 6 | 17
GABRP 6 | 10
GABRQ 6 | 10
GLRA1 6 | 45
KCNK3 6 | 107
KCNK10 5 | 6
KCNK18 5 | 5
KCNK2 5 | 20
KCNK9 5 | 46
GLRB 3 | 14
CA1 1 | 2,654
CA12 1 | 2,010
CA2 1 | 4,185
CA4 1 | 240
CA7 1 | 452
CFTR 1 | 179
CYP11B1 1 | 486
CYP11B2 1 | 711
GRIA1 1 | 77
GRIA2 1 | 166
GRIA3 1 | 21
GRIA4 1 | 40
GRIK2 1 | 85
GRIK3 1 | 20
GRIK4 1 | 1
GRIK5 1 | 21
GRIN1 1 | 59
GRIN2A 1 | 6
GRIN2B 1 | 119
GRIN2C 1 | 10
GRIN2D 1 | 5
GRIN3A 1 | 4
GRIN3B 1 | 3
KCNB1 1 | 13
KCNK5 1 | 2
MAPT 1 | 2,286
SCN1A 1 | 51
SCN5A 1 | 327
TRPA1 1 | 263

Pharmalogical Action

POSITIVE MODULATOR 15 | 15
INHIBITOR 542 | 542
AGONIST 427 | 427
ANTAGONIST 350 | 350
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
MODULATOR 20 | 20
OPENER 16 | 16
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

EC50 2 | 8,212
- 1 | 698
IC50 1 | 143,077
Ki 1 | 70,819
Potency 1 | 2,975

Ligand Activity Source

ChEMBL 3 | 220,950
Guide to Pharmacology 3 | 5,022

Ligand Source

CHEMBL 14 | 221,632
Guide to Pharmacology 3 | 5,022
DRUG LABEL 1 | 243