Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 3 | 855
Selleck FDA Approved Drug 3 | 410
NCATS MIPE 2 | 567

Development Level

Tclin 41 | 127,306
Tchem 1 | 103,180

Target Family

Ion Channel 39 | 16,308
Enzyme 2 | 84,773
GPCR 2 | 57,167

Target

GABRA1 38 | 139
GABRG2 38 | 48
GABRB2 32 | 37
GABRB3 26 | 52
GABRA2 21 | 131
GABRA3 20 | 61
GABRA5 18 | 472
GABRG3 14 | 17
GABRA4 12 | 20
GABRB1 12 | 14
GABRA6 11 | 24
GABRD 11 | 13
GABRG1 11 | 13
GABRE 8 | 10
GABRP 8 | 10
GABRQ 8 | 10
GLRA1 5 | 31
KCNK10 4 | 6
KCNK18 4 | 5
KCNK2 4 | 18
KCNK3 4 | 102
KCNK9 4 | 46
GLRB 3 | 3
ADORA3 1 | 1,687
CASR 1 | 93
CPS1 1 | 1
GUCY1B1 1 | 6

Pharmalogical Action

POSITIVE ALLOSTERIC MODULATOR 41 | 41
INHIBITOR 471 | 471
AGONIST 405 | 405
ANTAGONIST 314 | 314
BLOCKER 117 | 117
ANTIBODY BINDING 57 | 57
ACTIVATOR 28 | 28
MODULATOR 19 | 19
OPENER 15 | 15
POSITIVE MODULATOR 14 | 14
PARTIAL AGONIST 12 | 12
INVERSE AGONIST 8 | 8
GATING INHIBITOR 6 | 6
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
NEGATIVE ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 1 | 1
OTHER 1 | 1

Ligand Activity

EC50 3 | 7,763
Kd 2 | 2,644
Ki 2 | 69,787
IC50 1 | 141,067

Ligand Source

CHEMBL 37 | 221,399
KEGG DRUG 2 | 44
SCIENTIFIC LITERATURE 2 | 251
DRUG LABEL 1 | 219
IUPHAR 1 | 121