Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 41
Tchem 1

Target Family

Ion Channel 39
Enzyme 2
GPCR 2

Pharmalogical Action

POSITIVE ALLOSTERIC MODULATOR 41
INHIBITOR 441
AGONIST 405
ANTAGONIST 314
BLOCKER 117
ANTIBODY BINDING 57
ACTIVATOR 28
MODULATOR 19
OPENER 15
POSITIVE MODULATOR 14
PARTIAL AGONIST 12
INVERSE AGONIST 8
GATING INHIBITOR 6
RELEASING AGENT 5
SUBSTRATE 5
ALLOSTERIC MODULATOR 4
NEGATIVE ALLOSTERIC MODULATOR 4
PHARMACOLOGICAL CHAPERONE 3
ALLOSTERIC ANTAGONIST 1
OTHER 1

Ligand Source

CHEMBL 37
KEGG DRUG 2
SCIENTIFIC LITERATURE 2
DRUG LABEL 1
IUPHAR 1

Ligand Activity

EC50 3
Kd 2
Ki 2
IC50 1

Target

GABRA1 38
GABRG2 38
GABRB2 32
GABRB3 26
GABRA2 21
GABRA3 20
GABRA5 18
GABRG3 14
GABRA4 12
GABRB1 12
GABRA6 11
GABRD 11
GABRG1 11
GABRE 8
GABRP 8
GABRQ 8
GLRA1 5
KCNK10 4
KCNK18 4
KCNK2 4
KCNK3 4
KCNK9 4
GLRB 3
ADORA3 1
CASR 1
CPS1 1
GUCY1B1 1