Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 43
Tchem 3

Target Family

Ion Channel 42
GPCR 3
Enzyme 2

Pharmalogical Action

POSITIVE ALLOSTERIC MODULATOR 44
INHIBITOR 454
AGONIST 399
ANTAGONIST 310
BLOCKER 116
ANTIBODY BINDING 55
ACTIVATOR 27
MODULATOR 20
OPENER 17
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 37
IUPHAR 3
KEGG DRUG 2
DRUG LABEL 1
SCIENTIFIC LITERATURE 1

Ligand Activity

EC50 4
Kd 3
Ki 3
IC50 1

Target

GABRA1 39
GABRG2 38
GABRB2 32
GABRB3 26
GABRA2 22
GABRA3 21
GABRA5 19
GABRG3 14
GABRA4 12
GABRB1 12
GABRA6 11
GABRD 11
GABRG1 11
GABRE 8
GABRP 8
GABRQ 8
GLRA1 6
KCNK10 4
KCNK18 4
KCNK2 4
KCNK3 4
KCNK9 4
GLRB 3
GLRA2 2
GLRA3 2
ADORA3 1
CASR 1
CHRFAM7A 1
CNR1 1
CNR2 1
CPS1 1
GUCY1B3 1