Development Level

Tclin 20 | 130,166
Tchem 4 | 105,938

Target Family

Nuclear Receptor 9 | 7,246
Non-IDG 7 | 16,175
Ion Channel 4 | 16,788
Enzyme 3 | 85,645
GPCR 2 | 59,407
Transporter 2 | 9,204

Target

ESR1 7 | 967
ESR2 6 | 923
CACNA2D1 3 | 152
CACNA2D2 3 | 28
CRBN 3 | 3
EBP 2 | 43
SIGMAR1 2 | 1,854
SV2A 2 | 4
ABCB1 1 | 570
ABCB11 1 | 6
EBPL 1 | 5
FKBP1B 1 | 9
FKBP4 1 | 3
GPER1 1 | 8
KCNH2 1 | 4,432
OPRM1 1 | 1,833
PPIA 1 | 104
PPIB 1 | 8
PPID 1 | 7
PPP3CA 1 | 19
SLC10A1 1 | 10
SLCO1B1 1 | 6
SLCO1B3 1 | 5
TBXAS1 1 | 612

Pharmalogical Action

MODULATOR 20 | 20
INHIBITOR 542 | 542
AGONIST 427 | 427
ANTAGONIST 350 | 350
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

IC50 4 | 143,077
Ki 3 | 70,819
- 1 | 698

Ligand Activity Source

ChEMBL 4 | 220,950
Guide to Pharmacology 2 | 5,022

Ligand Source

CHEMBL 14 | 221,632
SCIENTIFIC LITERATURE 8 | 269
Guide to Pharmacology 2 | 5,022
IUPHAR 1 | 129