Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 453
Tchem 102

Target Family

Enzyme 307
Transporter 112
Non-IDG 71
Kinase 45
GPCR 29
Ion Channel 29
Epigenetic 8
Nuclear Receptor 7
Transcription Factor 7

Pharmalogical Action

INHIBITOR 454
AGONIST 399
ANTAGONIST 310
BLOCKER 116
ANTIBODY BINDING 55
POSITIVE ALLOSTERIC MODULATOR 44
ACTIVATOR 27
MODULATOR 20
OPENER 17
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 313
SCIENTIFIC LITERATURE 79
DRUG LABEL 35
IUPHAR 16
KEGG DRUG 11

Ligand Activity

IC50 206
Ki 85
Kd 28
EC50 11
Potency 7

Target

PTGS2 47
SLC6A2 39
PTGS1 38
SLC6A4 33
SLC6A3 24
ACE 19
CA2 18
ACHE 17
CA12 16
CA9 16
CA1 14
CA7 14
KCNH2 14
CA4 13
CA5A 13
CA5B 13
CA6 13
MAOA 13
SLC12A3 13
CA14 12
EGFR 12
ATP4B 11
KDR 11
KIT 11
PDE3A 11
TUBB 11
TUBB1 11
TUBB2A 11
TUBB2B 11
TUBB3 11
TUBB4A 11
TUBB4B 11
TUBB6 11
TUBB8 11
ABL1 10
ATP4A 10
CA13 10
DPP4 10
MAOB 10
SIGMAR1 10
CYP19A1 9
HMGCR 9
HTR2A 9
PDE5A 9
SLC18A2 9
F2 8
HRH1 8
HTR2C 8
PDE4A 8
PDE4B 8
PDGFRB 8
RET 8
TOP2A 8
ALOX5 7
BCHE 7
CHRM4 7
CYP2D6 7
FLT1 7
PDE4D 7
PDGFRA 7
CHRM3 6
CSF1R 6
DDR1 6
FDPS 6
FLT4 6
HTR2B 6
LCK 6
PDE3B 6
PDE4C 6
SLC5A2 6
ADORA3 5
ADRA2B 5
AKR1C3 5
CA3 5
CHRM1 5
CHRM5 5
CYP2C19 5
CYP3A4 5
DHFR 5
FGFR1 5
FKBP1A 5
FLT3 5
GAK 5
HDAC1 5
HDAC10 5
HDAC2 5
HDAC3 5
JAK1 5
SLC12A1 5
TDP1 5
TYMS 5
VKORC1 5
CHRM2 4
CXCL8 4
CYP11B1 4
DRD3 4
HDAC5 4
HDAC8 4
MAP3K19 4
PLG 4