Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 130 | 855
Selleck FDA Approved Drug 125 | 410
NCATS MIPE 92 | 567
Selleck Kinase Inhibitor 19 | 230
Selleck Target Selective Inhibitor 19 | 213

Development Level

Tclin 469 | 127,306
Tchem 101 | 103,180

Target Family

Enzyme 313 | 84,773
Transporter 112 | 9,020
Non-IDG 65 | 16,032
Kinase 52 | 33,162
Ion Channel 29 | 16,308
GPCR 28 | 57,167
Epigenetic 7 | 4,976
Nuclear Receptor 7 | 6,975
Transcription Factor 6 | 404

Target

PTGS2 49 | 1,543
SLC6A2 40 | 2,194
PTGS1 38 | 317
SLC6A4 33 | 3,404
SLC6A3 24 | 1,746
ACE 19 | 315
ACHE 18 | 1,867
CA2 18 | 4,179
CA12 16 | 1,996
CA9 16 | 2,401
KCNH2 16 | 4,416
CA1 14 | 2,641
CA7 14 | 442
CA4 13 | 235
CA5A 13 | 137
CA5B 13 | 101
CA6 13 | 98
EGFR 13 | 1,393
SLC12A3 13 | 13
CA14 12 | 414
KDR 12 | 1,651
MAOA 12 | 464
DPP4 11 | 3,095
KIT 11 | 334
PDE3A 11 | 129
SIGMAR1 11 | 1,848
TUBB 11 | 11
TUBB1 11 | 31
TUBB2A 11 | 11
TUBB2B 11 | 11
TUBB3 11 | 17
TUBB4A 11 | 11
TUBB4B 11 | 11
TUBB6 11 | 11
TUBB8 11 | 11
ABL1 10 | 613
ATP4A 10 | 10
ATP4B 10 | 10
CA13 10 | 139
HTR2A 10 | 1,998
MAOB 10 | 1,057
HMGCR 9 | 177
PDE5A 9 | 1,108
SLC18A2 9 | 12
CYP19A1 8 | 1,134
CYP2D6 8 | 42
F2 8 | 2,715
FLT1 8 | 151
HRH1 8 | 485
HTR2C 8 | 1,154
PDE4A 8 | 512
PDE4B 8 | 804
PDGFRA 8 | 117
PDGFRB 8 | 283
RET 8 | 134
TOP2A 8 | 20
ALOX5 7 | 751
CHRM4 7 | 203
FLT3 7 | 491
FLT4 7 | 83
PDE4D 7 | 432
SLC5A2 7 | 946
BCHE 6 | 813
CHRM3 6 | 894
CSF1R 6 | 401
DDR1 6 | 44
FDPS 6 | 145
HTR2B 6 | 467
LCK 6 | 480
MAP3K19 6 | 15
PDE3B 6 | 74
PDE4C 6 | 79
ADORA3 5 | 1,687
ADRA2B 5 | 162
AKR1C3 5 | 244
BTK 5 | 354
CA3 5 | 15
CHRM1 5 | 556
CHRM5 5 | 127
CYP2C19 5 | 39
CYP3A4 5 | 53
DHFR 5 | 510
FGFR1 5 | 325
FKBP1A 5 | 341
GAK 5 | 17
HDAC1 5 | 2,252
HDAC10 5 | 175
HDAC2 5 | 622
HDAC3 5 | 567
JAK1 5 | 1,067
MAP2K1 5 | 221
SLC12A1 5 | 5
TDP1 5 | 782
VKORC1 5 | 5
ALK 4 | 523
CHRM2 4 | 610
CYP11B1 4 | 483
HDAC5 4 | 81
STK10 4 | 13
TYMS 4 | 288

Pharmalogical Action

INHIBITOR 471 | 471
AGONIST 405 | 405
ANTAGONIST 314 | 314
BLOCKER 117 | 117
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 41 | 41
ACTIVATOR 28 | 28
MODULATOR 19 | 19
OPENER 15 | 15
POSITIVE MODULATOR 14 | 14
PARTIAL AGONIST 12 | 12
INVERSE AGONIST 8 | 8
GATING INHIBITOR 6 | 6
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
NEGATIVE ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 1 | 1
OTHER 1 | 1

Ligand Activity

IC50 207 | 141,067
Ki 83 | 69,787
Kd 29 | 2,644
EC50 11 | 7,763
Potency 7 | 2,975

Ligand Source

CHEMBL 327 | 221,399
SCIENTIFIC LITERATURE 98 | 251
DRUG LABEL 64 | 219
IUPHAR 30 | 121
KEGG DRUG 14 | 44